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Protein

Beta-galactosidase

Gene

bgalB

Organism
Thermotoga neapolitana
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:bgalBImported
OrganismiThermotoga neapolitanaImported
Taxonomic identifieri2337 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi309803.CTN_1382.

Structurei

3D structure databases

ProteinModelPortaliO85250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini715 – 982268Bgal_small_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYEWENPQL VSEGTEKPHA SFIPYLNPFT GEWEYPDDFI LLNGNWKFFF
60 70 80 90 100
AKNPFEVPEN FFLEGFDDTN WDEIEVPSNW EMKGYGKPIY TNVVYPFEPN
110 120 130 140 150
PPFVPKDDNP TGIYRRWVEV PEEWFEKEIF LHFEGVRSFF YLWVNGKRMG
160 170 180 190 200
FSKDSCTPAE FRVTDVLKPG KNLICVEVLK WSDGSYLEDQ DMWWFAGIYR
210 220 230 240 250
DVYLYALSKF HVRDIFVRTD LDEDYRDGKI FLDVELRNLG EEKEKDLIIT
260 270 280 290 300
LTDPQGKEMT LVEERVGPKN ETLSFVFEVK DPKKWSAETP HLYVLKVELG
310 320 330 340 350
EDEKKVNFGF KKVEVKDGRL LFNGKPLYIK GVNRHEFDPD RGHAVTVERM
360 370 380 390 400
IQDIKLMKQH NINTVRTSHY PNQTKWYDLC DYYGLYVIDE ANIESHGIGE
410 420 430 440 450
APEVTLANRP EWEKAHLDRI KRMVERDKNH PSIIFWSLGN EAGDGMNFEK
460 470 480 490 500
AALWIKERDN TRLVHYEGTT RRGESYYVDV FSLMYPKIDV LLEYASRKRE
510 520 530 540 550
KPFIMCEYAH AMGNSVGNLK DYWDVIEKYP YLHGGCIWDW VDQGIRKKDE
560 570 580 590 600
NGKEFWAYGG DFGDEPNDKN FCCNGVVLPD RTPEPELYEV KKFYQNIKVR
610 620 630 640 650
QIAKDTYEVE NGYLFTDLEM FDGTWRIRKD GEVVREERFK LSARPGEKKI
660 670 680 690 700
LKIPLPEMED SEYFLEICFS LSEDTLWAKK GHVVAWEQFL IKPPSFEKTV
710 720 730 740 750
VRESVDLSED GRHLFVRSKD TELVFSKFTG LLKRIVYRGR NILTGSIVPN
760 770 780 790 800
FWRVPTDNDV GNKMPERLSI WKRASKERKL FKMFFWKKEE NSVSVQSVYQ
810 820 830 840 850
VPGNSWVYLT YTIFGNGDIL VDLSLIPAEG VPEIPRIGLQ FAVPGDFRFV
860 870 880 890 900
EWYGRGPHET YWDRKESGLF ARYRRTVQDM IHRYVRPQET GNRSDVRWFA
910 920 930 940 950
LSDGRVNLFV SGMPVVDFSV WPFSMEDLEK ADHVNELPER DFVTVNVDYR
960 970 980 990 1000
QMGLGGDDSW GAQPHLEYRL LPEPYRFSFR MRVSEEILSW RVLPAISETL
1010 1020 1030 1040 1050
HAEMSSEDMI REGDTLKVKL SLLNDSPLSR KDQIILFVDG KEHSAKKVVI
1060 1070 1080
PPFKEETLVF KVNGLKRGEH LVSTSLNTGK TIYVR
Length:1,085
Mass (Da):127,330
Last modified:November 1, 1998 - v1
Checksum:i8A1DD29C4659D785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055482 Genomic DNA. Translation: AAC24219.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055482 Genomic DNA. Translation: AAC24219.1.

3D structure databases

ProteinModelPortaliO85250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309803.CTN_1382.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular Characterization of a galactose utilization operon in Thermotoga neapolitana."
    Swiatek G.C., Yernool D.A., King M., Chassy B., Eveleigh D.E.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO85250_THENE
AccessioniPrimary (citable) accession number: O85250
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.