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O85222

- ANR_PSEPH

UniProt

O85222 - ANR_PSEPH

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Protein
Transcriptional activator protein Anr
Gene
anr
Organism
Pseudomonas protegens (strain DSM 19095 / CHA0)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator of anaerobic gene expression. Regulates the expression of the components of the hydrogen cyanide synthase (HcnABC) in a positive manner. May also act as an iron sensor.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 149129cNMP By similarityBy similarity
Add
BLAST
DNA bindingi192 – 21120H-T-H motif By similarityBy similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein Anr
Short name:
ANR
Alternative name(s):
Anaerobic regulatory protein
Gene namesi
Name:anr
OrganismiPseudomonas protegens (strain DSM 19095 / CHA0)
Taxonomic identifieri1124983 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Transcriptional activator protein Anr
PRO_0000419765Add
BLAST

Expressioni

Inductioni

Up-regulated by Fe3+ levels in oxygen-limiting conditions.2 Publications

Structurei

3D structure databases

ProteinModelPortaliO85222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 23274HTH crp-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85222-1 [UniParc]FASTAAdd to Basket

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MSEPVKLRAH NQAHCKDCSL APLCLPLSLN LEDMDALDEI VKRGRPLKKG    50
EFLFRQGDGF DSVYAVRSGA LKTFSLSDSG EEQITGFHLP SELVGLSGMD 100
TESHPVSAQA LETTSVCEIP FERLDELALQ LPQLRRQLMR VMSREIRDDQ 150
QMMLLLSKKT ADERIATFLV NLSARFRARG FSANQFRLSM SRNEIGNYLG 200
LAVETVSRVF TRFQQNELIA AEGKEVHILD PIQLCALAGG SVEG 244
Length:244
Mass (Da):27,155
Last modified:November 1, 1998 - v1
Checksum:i867AC251594A051F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053611 Genomic DNA. Translation: AAC38593.1.
RefSeqiYP_007999236.1. NC_021237.1.

Genome annotation databases

GeneIDi15559866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053611 Genomic DNA. Translation: AAC38593.1 .
RefSeqi YP_007999236.1. NC_021237.1.

3D structure databases

ProteinModelPortali O85222.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15559866.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0."
    Laville J., Blumer C., Von Schroetter C., Gaia V., Defago G., Keel C., Haas D.
    J. Bacteriol. 180:3187-3196(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: DSM 19095 / CHA0.
  2. "Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0."
    Blumer C., Haas D.
    Microbiology 146:2417-2424(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
    Strain: DSM 19095 / CHA0.

Entry informationi

Entry nameiANR_PSEPH
AccessioniPrimary (citable) accession number: O85222
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron) By similarity.By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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