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O85222

- ANR_PSEPH

UniProt

O85222 - ANR_PSEPH

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Protein

Transcriptional activator protein Anr

Gene

anr

Organism
Pseudomonas protegens (strain DSM 19095 / CHA0)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional activator of anaerobic gene expression. Regulates the expression of the components of the hydrogen cyanide synthase (HcnABC) in a positive manner. May also act as an iron sensor.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 149129cNMPBy similarityPROSITE-ProRule annotationAdd
BLAST
DNA bindingi192 – 21120H-T-H motifBy similarityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein Anr1 Publication
Short name:
ANR1 Publication
Alternative name(s):
Anaerobic regulatory proteinImported
Gene namesi
Name:anrImported
OrganismiPseudomonas protegens (strain DSM 19095 / CHA0)
Taxonomic identifieri1124983 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Transcriptional activator protein AnrPRO_0000419765Add
BLAST

Expressioni

Inductioni

Up-regulated by Fe3+ levels in oxygen-limiting conditions.2 Publications

Structurei

3D structure databases

ProteinModelPortaliO85222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 23274HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85222-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEPVKLRAH NQAHCKDCSL APLCLPLSLN LEDMDALDEI VKRGRPLKKG
60 70 80 90 100
EFLFRQGDGF DSVYAVRSGA LKTFSLSDSG EEQITGFHLP SELVGLSGMD
110 120 130 140 150
TESHPVSAQA LETTSVCEIP FERLDELALQ LPQLRRQLMR VMSREIRDDQ
160 170 180 190 200
QMMLLLSKKT ADERIATFLV NLSARFRARG FSANQFRLSM SRNEIGNYLG
210 220 230 240
LAVETVSRVF TRFQQNELIA AEGKEVHILD PIQLCALAGG SVEG
Length:244
Mass (Da):27,155
Last modified:November 1, 1998 - v1
Checksum:i867AC251594A051F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053611 Genomic DNA. Translation: AAC38593.1.
RefSeqiYP_007999236.1. NC_021237.1.

Genome annotation databases

GeneIDi15559866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053611 Genomic DNA. Translation: AAC38593.1 .
RefSeqi YP_007999236.1. NC_021237.1.

3D structure databases

ProteinModelPortali O85222.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15559866.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0."
    Laville J., Blumer C., Von Schroetter C., Gaia V., Defago G., Keel C., Haas D.
    J. Bacteriol. 180:3187-3196(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: DSM 19095 / CHA0.
  2. "Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0."
    Blumer C., Haas D.
    Microbiology 146:2417-2424(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
    Strain: DSM 19095 / CHA0.

Entry informationi

Entry nameiANR_PSEPH
AccessioniPrimary (citable) accession number: O85222
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3