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O85222

- ANR_PSEPH

UniProt

O85222 - ANR_PSEPH

Protein

Transcriptional activator protein Anr

Gene

anr

Organism
Pseudomonas protegens (strain DSM 19095 / CHA0)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Transcriptional activator of anaerobic gene expression. Regulates the expression of the components of the hydrogen cyanide synthase (HcnABC) in a positive manner. May also act as an iron sensor.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 149129cNMPBy similarityPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi192 – 21120H-T-H motifBy similarityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator protein Anr1 Publication
    Short name:
    ANR1 Publication
    Alternative name(s):
    Anaerobic regulatory proteinImported
    Gene namesi
    Name:anrImported
    OrganismiPseudomonas protegens (strain DSM 19095 / CHA0)
    Taxonomic identifieri1124983 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Transcriptional activator protein AnrPRO_0000419765Add
    BLAST

    Expressioni

    Inductioni

    Up-regulated by Fe3+ levels in oxygen-limiting conditions.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliO85222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 23274HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O85222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEPVKLRAH NQAHCKDCSL APLCLPLSLN LEDMDALDEI VKRGRPLKKG    50
    EFLFRQGDGF DSVYAVRSGA LKTFSLSDSG EEQITGFHLP SELVGLSGMD 100
    TESHPVSAQA LETTSVCEIP FERLDELALQ LPQLRRQLMR VMSREIRDDQ 150
    QMMLLLSKKT ADERIATFLV NLSARFRARG FSANQFRLSM SRNEIGNYLG 200
    LAVETVSRVF TRFQQNELIA AEGKEVHILD PIQLCALAGG SVEG 244
    Length:244
    Mass (Da):27,155
    Last modified:November 1, 1998 - v1
    Checksum:i867AC251594A051F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053611 Genomic DNA. Translation: AAC38593.1.
    RefSeqiYP_007999236.1. NC_021237.1.

    Genome annotation databases

    GeneIDi15559866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053611 Genomic DNA. Translation: AAC38593.1 .
    RefSeqi YP_007999236.1. NC_021237.1.

    3D structure databases

    ProteinModelPortali O85222.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15559866.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0."
      Laville J., Blumer C., Von Schroetter C., Gaia V., Defago G., Keel C., Haas D.
      J. Bacteriol. 180:3187-3196(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
      Strain: DSM 19095 / CHA0.
    2. "Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0."
      Blumer C., Haas D.
      Microbiology 146:2417-2424(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
      Strain: DSM 19095 / CHA0.

    Entry informationi

    Entry nameiANR_PSEPH
    AccessioniPrimary (citable) accession number: O85222
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2012
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Possesses 4 cysteines which may bind a metal ion (possibly iron).By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3