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O85142

- O85142_STAAU

UniProt

O85142 - O85142_STAAU

Protein
Submitted name:

ArsR family transcriptional regulator

Gene

rzcA

Organism
Staphylococcus aureus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841ZincImported
    Metal bindingi86 – 861Zinc; via pros nitrogenImported
    Metal bindingi97 – 971Zinc; via pros nitrogenImported
    Metal bindingi100 – 1001Zinc; via tele nitrogenImported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation, Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ArsR family transcriptional regulatorImported
    Submitted name:
    CzrA proteinImported
    Submitted name:
    HTH-type transcriptional repressor CzrAImported
    Submitted name:
    Repressor proteinImported
    Submitted name:
    Zinc and cobalt transport repressor proteinImported
    Gene namesi
    Name:rzcAImported
    Synonyms:CzrAImported, czrAImported
    ORF Names:CH52_08235Imported, DA92_03705Imported, EX97_11010Imported, SAXN108_2391Imported, X998_2124Imported
    OrganismiStaphylococcus aureusImported
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000019580: Chromosome

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-49001N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R1UX-ray2.00A/B/C/D1-106[»]
    1R1VX-ray2.30A/B1-106[»]
    2KJBNMR-A/B1-106[»]
    2KJCNMR-A/B1-106[»]
    2M30NMR-A/B1-106[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO85142.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PRINTSiPR00778. HTHARSR.
    SMARTiSM00418. HTH_ARSR. 1 hit.
    [Graphical view]
    PROSITEiPS50987. HTH_ARSR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O85142-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN    50
    LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH 100
    PKESGL 106
    Length:106
    Mass (Da):11,989
    Last modified:November 1, 1998 - v1
    Checksum:iD3EB24D10D5EA4BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044951 Genomic DNA. Translation: AAC32484.1.
    CP007454 Genomic DNA. Translation: AHM70293.1.
    CP007539 Genomic DNA. Translation: AHW65763.1.
    CP007690 Genomic DNA. Translation: AIA28639.1.
    CP007447 Genomic DNA. Translation: AID40832.1.
    AB016431 Genomic DNA. Translation: BAA36687.1.
    JMBU01000149 Genomic DNA. Translation: KDA08569.1.
    PIRiT44366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044951 Genomic DNA. Translation: AAC32484.1 .
    CP007454 Genomic DNA. Translation: AHM70293.1 .
    CP007539 Genomic DNA. Translation: AHW65763.1 .
    CP007690 Genomic DNA. Translation: AIA28639.1 .
    CP007447 Genomic DNA. Translation: AID40832.1 .
    AB016431 Genomic DNA. Translation: BAA36687.1 .
    JMBU01000149 Genomic DNA. Translation: KDA08569.1 .
    PIRi T44366.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R1U X-ray 2.00 A/B/C/D 1-106 [» ]
    1R1V X-ray 2.30 A/B 1-106 [» ]
    2KJB NMR - A/B 1-106 [» ]
    2KJC NMR - A/B 1-106 [» ]
    2M30 NMR - A/B 1-106 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-49001N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei O85142.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PRINTSi PR00778. HTHARSR.
    SMARTi SM00418. HTH_ARSR. 1 hit.
    [Graphical view ]
    PROSITEi PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus."
      Xiong A., Jayaswal R.K.
      J. Bacteriol. 180:4024-4029(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: RN450Imported.
    2. "Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912."
      Kuroda M., Hayashi H., Ohta T.
      Microbiol. Immunol. 43:115-125(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 912Imported.
    3. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
      Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
      J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
    4. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
      Arunkumar A.I., Campanello G.C., Giedroc D.P.
      Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    5. "First report of a sequence type 239 vancomycin-intermediate Staphylococcus aureus isolate in Mainland China."
      Zhang X., Hu Q., Yuan W., Shang W., Cheng H., Yuan J., Zhu J., Hu Z., Li S., Chen W., Hu X., Rao X.
      Diagn. Microbiol. Infect. Dis. 77:64-68(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: XN108Imported.
    6. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
      Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
      J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
    7. "Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
      Parker D., Narechania A., Sebra R., Deikus G., Larussa S., Ryan C., Smith H., Prince A., Mathema B., Ratner A.J., Kreiswirth B., Planet P.J.
      Genome Announc. 2:e00284-14(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 502AImported.
    8. "Genome sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
      Parker D., Narechania A., Sebra R., Planet P.J.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Genome sequence of Staphylococcus aureus NRS 100."
      Sichtig H., Utter B., Tallon L.J., Deshong S.Lisa., Sengamalay N., Nagaraj S., McCracken C.L., Daugherty S.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NRS 100Imported.
    10. "Draft genomes of heterogeneous vancomycin-intermediate Staphylococcus aureus strain MM66 and a MM66 variant selected for increased vancomycin susceptibility."
      Matyi S.A., Nelson M., Hoyt P.R., Gustafson J.E.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MM66RVI-4Imported.
    11. "Complete genome sequences of two prolific biofilm forming Staphylococcus aureus isolates, belonging to EMRSA15 and USA300 clonal lineages."
      Sabirova J., Britto Xavier B., Goossens H., Malhotra-Kumar S.
      Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UA-S391_USA300Imported.
    12. Zhang X., Rao X.
      Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: XN108Imported.

    Entry informationi

    Entry nameiO85142_STAAU
    AccessioniPrimary (citable) accession number: O85142
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3