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O85142

- O85142_STAAU

UniProt

O85142 - O85142_STAAU

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Protein
Submitted name:

ArsR family transcriptional regulator

Gene
rzcA, CzrA, czrA, CH52_08235, DA92_03705, X998_2124
Organism
Staphylococcus aureus
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841ZincImported
Metal bindingi86 – 861Zinc; via pros nitrogenImported
Metal bindingi97 – 971Zinc; via pros nitrogenImported
Metal bindingi100 – 1001Zinc; via tele nitrogenImported

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
ArsR family transcriptional regulatorImported
Submitted name:
CzrA proteinImported
Submitted name:
HTH-type transcriptional repressor CzrAImported
Submitted name:
Repressor proteinImported
Gene namesi
Name:rzcAImported
Synonyms:CzrAImported, czrAImported
ORF Names:CH52_08235Imported, DA92_03705Imported, X998_2124Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000019580: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-49001N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]

Miscellaneous databases

EvolutionaryTraceiO85142.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85142-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN    50
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH 100
PKESGL 106
Length:106
Mass (Da):11,989
Last modified:November 1, 1998 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP007454 Genomic DNA. Translation: AHM70293.1.
CP007539 Genomic DNA. Translation: AHW65763.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
JMBU01000149 Genomic DNA. Translation: KDA08569.1.
PIRiT44366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1 .
CP007454 Genomic DNA. Translation: AHM70293.1 .
CP007539 Genomic DNA. Translation: AHW65763.1 .
AB016431 Genomic DNA. Translation: BAA36687.1 .
JMBU01000149 Genomic DNA. Translation: KDA08569.1 .
PIRi T44366.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R1U X-ray 2.00 A/B/C/D 1-106 [» ]
1R1V X-ray 2.30 A/B 1-106 [» ]
2KJB NMR - A/B 1-106 [» ]
2KJC NMR - A/B 1-106 [» ]
2M30 NMR - A/B 1-106 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-49001N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei O85142.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PRINTSi PR00778. HTHARSR.
SMARTi SM00418. HTH_ARSR. 1 hit.
[Graphical view ]
PROSITEi PS50987. HTH_ARSR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus."
    Xiong A., Jayaswal R.K.
    J. Bacteriol. 180:4024-4029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RN450Imported.
  2. "Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912."
    Kuroda M., Hayashi H., Ohta T.
    Microbiol. Immunol. 43:115-125(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 912Imported.
  3. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
    Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
    J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
  4. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
    Arunkumar A.I., Campanello G.C., Giedroc D.P.
    Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
    Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
    J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
  6. "Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
    Parker D., Narechania A., Sebra R., Deikus G., Larussa S., Ryan C., Smith H., Prince A., Mathema B., Ratner A.J., Kreiswirth B., Planet P.J.
    Genome Announc. 2:e00284-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 502AImported.
  7. "Genome sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
    Parker D., Narechania A., Sebra R., Planet P.J.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Genome sequence of Staphylococcus aureus NRS 100."
    Sichtig H., Utter B., Tallon L.J., Deshong S.Lisa., Sengamalay N., Nagaraj S., McCracken C.L., Daugherty S.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRS 100Imported.
  9. "Draft genomes of heterogeneous vancomycin-intermediate Staphylococcus aureus strain MM66 and a MM66 variant selected for increased vancomycin susceptibility."
    Matyi S.A., Nelson M., Hoyt P.R., Gustafson J.E.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MM66RVI-4Imported.

Entry informationi

Entry nameiO85142_STAAU
AccessioniPrimary (citable) accession number: O85142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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