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Protein
Submitted name:

ArsR family transcriptional regulator

Gene

rzcA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841ZincCombined sources
Metal bindingi86 – 861Zinc; via pros nitrogenCombined sources
Metal bindingi97 – 971Zinc; via pros nitrogenCombined sources
Metal bindingi100 – 1001Zinc; via tele nitrogenCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
ArsR family transcriptional regulatorImported
Submitted name:
CzrA proteinImported
Submitted name:
Repressor proteinImported
Submitted name:
Zinc and cobalt transport repressor CzrAImported
Submitted name:
Zn(II) or Co(II)-specific transcriptional repressor proteinImported
Gene namesi
Name:rzcAImported
Synonyms:CzrAImported, czrAImported
ORF Names:AL077_08685Imported, AL078_07495Imported, AM595_11170Imported, AN169_07960Imported, CH51_11585Imported, EQ80_010805Imported, ER12_010790Imported, ERS365775_02441Imported, ERS410449_02730Imported, ERS411009_02732Imported, ERS411017_02707Imported, ERS445051_02103Imported, ERS445052_01256Imported, RL02_00800Imported, RT87_11040Imported, SAFDA_2019Imported
Encoded oniPlasmid 2Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000042582 Componenti: Unassembled WGS sequence UP000038569 Componenti: Unassembled WGS sequence UP000028937 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-49001N.
STRINGi93062.SACOL2137.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 10295HTH arsR-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0640. LUCA.
ENOG4105KTU. Bacteria.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN
60 70 80 90 100
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH

PKESGL
Length:106
Mass (Da):11,989
Last modified:November 1, 1998 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP007499 Genomic DNA. Translation: AIL58650.1.
CP012593 Genomic DNA. Translation: ALC95093.1.
CP010890 Genomic DNA. Translation: ALD81676.1.
CP007676 Genomic DNA. Translation: ALK37370.1.
CP007672 Genomic DNA. Translation: ALK39973.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
AP014942 Genomic DNA. Translation: BAS52220.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
CYJR01000008 Genomic DNA. Translation: CUD32840.1.
CYKZ01000009 Genomic DNA. Translation: CUE54415.1.
CYNE01000011 Genomic DNA. Translation: CUF86871.1.
CYNC01000015 Genomic DNA. Translation: CUG03791.1.
JYAV01000001 Genomic DNA. Translation: KLN11024.1.
LIZM01000053 Genomic DNA. Translation: KOS65512.1.
LIGV01000012 Genomic DNA. Translation: KQB70224.1.
LIGW01000008 Genomic DNA. Translation: KQB72467.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_LN626917.1.

Genome annotation databases

EnsemblBacteriaiAIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AKJ49908; AKJ49908; AA961_10825.
AKK59279; AKK59279; EP54_11260.
AKK61843; AKK61843; EQ90_10805.
CEF82294; CEF82294; SAU060112_60086.
CEH26932; CEH26932; CEH26932.
KII20603; KII20603; JN533_14930.
KIX70655; KIX70655; RC78_13550.
KIX74989; KIX74989; RC80_06895.
KLL99786; KLL99786; RK64_11160.
KLM01995; KLM01995; RK60_10795.
KLM04013; KLM04013; RK61_06680.
KLM06607; KLM06607; RK66_14670.
KLM09206; KLM09206; RK70_13185.
KLM09359; KLM09359; RK75_13470.
KLM12915; KLM12915; RK65_00705.
KLM18044; KLM18044; RK73_08150.
KLM19518; KLM19518; RK68_01710.
KLM27962; KLM27962; RK79_14120.
KLM28424; KLM28424; RK63_01755.
KLM32625; KLM32625; RK74_09585.
KLM33158; KLM33158; RK69_09135.
KLM36743; KLM36743; RK78_14085.
KLM37102; KLM37102; RK72_01550.
KLM41411; KLM41411; RK67_07350.
KLM47501; KLM47501; RK62_03535.
KLM49267; KLM49267; RK76_00140.
KLM50798; KLM50798; RK80_07605.
KLM53878; KLM53878; RK85_08265.
KLM57729; KLM57729; RK86_09975.
KLM58162; KLM58162; RK71_01750.
KLM63377; KLM63377; RK83_14335.
KLM65584; KLM65584; RK82_08060.
KLM69128; KLM69128; RK81_14265.
KLM70220; KLM70220; RK89_03750.
KLM73310; KLM73310; RK84_08610.
KLM76506; KLM76506; RK91_00795.
KLM79429; KLM79429; RK92_12795.
KLM80928; KLM80928; RK87_06180.
KLM84223; KLM84223; RK90_08790.
KLM88015; KLM88015; RK88_14470.
KLM89806; KLM89806; RK98_09195.
KLM93615; KLM93615; RK99_02270.
KLM95103; KLM95103; RK94_00420.
KLM99817; KLM99817; RK95_10025.
KLN02766; KLN02766; RL04_07015.
KLN06859; KLN06859; RK96_10540.
KLN08696; KLN08696; RL06_03720.
KLN11024; KLN11024; RL02_00800.
KLN16528; KLN16528; RL01_13800.
KLN19048; KLN19048; RL08_11260.
KLN22235; KLN22235; RK93_11440.
KLN25602; KLN25602; RL00_13740.
KLN26801; KLN26801; RL03_05590.
KLN28821; KLN28821; RL05_04065.
KLN32017; KLN32017; RL07_00100.
GeneIDi23197940.
KEGGisaud:CH52_08235.
sauf:X998_2124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP007499 Genomic DNA. Translation: AIL58650.1.
CP012593 Genomic DNA. Translation: ALC95093.1.
CP010890 Genomic DNA. Translation: ALD81676.1.
CP007676 Genomic DNA. Translation: ALK37370.1.
CP007672 Genomic DNA. Translation: ALK39973.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
AP014942 Genomic DNA. Translation: BAS52220.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
CYJR01000008 Genomic DNA. Translation: CUD32840.1.
CYKZ01000009 Genomic DNA. Translation: CUE54415.1.
CYNE01000011 Genomic DNA. Translation: CUF86871.1.
CYNC01000015 Genomic DNA. Translation: CUG03791.1.
JYAV01000001 Genomic DNA. Translation: KLN11024.1.
LIZM01000053 Genomic DNA. Translation: KOS65512.1.
LIGV01000012 Genomic DNA. Translation: KQB70224.1.
LIGW01000008 Genomic DNA. Translation: KQB72467.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_LN626917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49001N.
STRINGi93062.SACOL2137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AKJ49908; AKJ49908; AA961_10825.
AKK59279; AKK59279; EP54_11260.
AKK61843; AKK61843; EQ90_10805.
CEF82294; CEF82294; SAU060112_60086.
CEH26932; CEH26932; CEH26932.
KII20603; KII20603; JN533_14930.
KIX70655; KIX70655; RC78_13550.
KIX74989; KIX74989; RC80_06895.
KLL99786; KLL99786; RK64_11160.
KLM01995; KLM01995; RK60_10795.
KLM04013; KLM04013; RK61_06680.
KLM06607; KLM06607; RK66_14670.
KLM09206; KLM09206; RK70_13185.
KLM09359; KLM09359; RK75_13470.
KLM12915; KLM12915; RK65_00705.
KLM18044; KLM18044; RK73_08150.
KLM19518; KLM19518; RK68_01710.
KLM27962; KLM27962; RK79_14120.
KLM28424; KLM28424; RK63_01755.
KLM32625; KLM32625; RK74_09585.
KLM33158; KLM33158; RK69_09135.
KLM36743; KLM36743; RK78_14085.
KLM37102; KLM37102; RK72_01550.
KLM41411; KLM41411; RK67_07350.
KLM47501; KLM47501; RK62_03535.
KLM49267; KLM49267; RK76_00140.
KLM50798; KLM50798; RK80_07605.
KLM53878; KLM53878; RK85_08265.
KLM57729; KLM57729; RK86_09975.
KLM58162; KLM58162; RK71_01750.
KLM63377; KLM63377; RK83_14335.
KLM65584; KLM65584; RK82_08060.
KLM69128; KLM69128; RK81_14265.
KLM70220; KLM70220; RK89_03750.
KLM73310; KLM73310; RK84_08610.
KLM76506; KLM76506; RK91_00795.
KLM79429; KLM79429; RK92_12795.
KLM80928; KLM80928; RK87_06180.
KLM84223; KLM84223; RK90_08790.
KLM88015; KLM88015; RK88_14470.
KLM89806; KLM89806; RK98_09195.
KLM93615; KLM93615; RK99_02270.
KLM95103; KLM95103; RK94_00420.
KLM99817; KLM99817; RK95_10025.
KLN02766; KLN02766; RL04_07015.
KLN06859; KLN06859; RK96_10540.
KLN08696; KLN08696; RL06_03720.
KLN11024; KLN11024; RL02_00800.
KLN16528; KLN16528; RL01_13800.
KLN19048; KLN19048; RL08_11260.
KLN22235; KLN22235; RK93_11440.
KLN25602; KLN25602; RL00_13740.
KLN26801; KLN26801; RL03_05590.
KLN28821; KLN28821; RL05_04065.
KLN32017; KLN32017; RL07_00100.
GeneIDi23197940.
KEGGisaud:CH52_08235.
sauf:X998_2124.

Phylogenomic databases

eggNOGiCOG0640. LUCA.
ENOG4105KTU. Bacteria.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
    Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
    J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
    Plasmid: 2
  2. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
    Arunkumar A.I., Campanello G.C., Giedroc D.P.
    Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
    Plasmid: 2
  3. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
    Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
    J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
    Plasmid: 2
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2395 USA500Imported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HOU1444-VRImported.
  6. "Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America."
    Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G., Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J., Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M., Robinson D.A., Arias C.A.
    J. Infect. Dis. 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CA12Imported and HUV05Imported.
  7. "The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen Staphylococcus aureus."
    Giraud C., Hausmann S., Lemeille S., Prados J., Redder P., Linder P.
    RNA Biol. 12:658-674(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SA564Imported.
  8. "Analysis of methicillin-resistant Staphylococcus aureus ST5 and ST30 strains colonizing healthy children in public daycare centers in Niteroi, Brazil."
    Stephens C.M., Cho P.J., Braga E.D., Cardoso C.A., Riley L.W., Alves F.A.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CC175Imported and CC445Imported.
  9. "Complete Genome Sequence of a Drug-naive Classical Staphylococcus aureus Strain FDA209P."
    Singh M., Sasaki T., Matsuo M., Morimoto Y., Hiramatsu K.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FDA209PImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MRSA SKN07Imported.
  11. "Genome analysis of Pseudomonas syringae pv. porri LMG."
    Rombouts S.
    Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2588STDY5627554Imported and 2588STDY5748758Imported.

Entry informationi

Entry nameiO85142_STAAU
AccessioniPrimary (citable) accession number: O85142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.