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Protein
Submitted name:

ArsR family transcriptional regulator

Gene

rzcA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841ZincCombined sources
Metal bindingi86 – 861Zinc; via pros nitrogenCombined sources
Metal bindingi97 – 971Zinc; via pros nitrogenCombined sources
Metal bindingi100 – 1001Zinc; via tele nitrogenCombined sources

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
ArsR family transcriptional regulatorImported
Submitted name:
CzrA proteinImported
Submitted name:
HTH-type transcriptional repressor CzrAImported
Submitted name:
Repressor proteinImported
Submitted name:
Zinc and cobalt transport repressor proteinImported
Submitted name:
Zn(II) or Co(II)-specific transcriptional repressor proteinImported
Gene namesi
Name:rzcAImported
Synonyms:CzrAImported, czrAImported
ORF Names:CH51_11585Imported, CH52_08235Imported, DA92_03705Imported, DP18_2501Imported, EW35_2512Imported, EX97_11010Imported, QT38_11535Imported, RM27_11540Imported, RM28_11535Imported, RM29_11540Imported, RM30_11535Imported, RM31_11545Imported, SAU060112_60086Imported, SAXN108_2391Imported, X998_2124Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000019580: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-49001N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO85142.

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN
60 70 80 90 100
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH

PKESGL
Length:106
Mass (Da):11,989
Last modified:November 1, 1998 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP007454 Genomic DNA. Translation: AHM70293.1.
CP007539 Genomic DNA. Translation: AHW65763.1.
CP007690 Genomic DNA. Translation: AIA28639.1.
CP007447 Genomic DNA. Translation: AID40832.1.
CP007499 Genomic DNA. Translation: AIL58650.1.
CP010295 Genomic DNA. Translation: AJC29525.1.
CP010296 Genomic DNA. Translation: AJC32371.1.
CP010297 Genomic DNA. Translation: AJC35214.1.
CP010298 Genomic DNA. Translation: AJC38064.1.
CP010299 Genomic DNA. Translation: AJC40902.1.
CP010300 Genomic DNA. Translation: AJC43748.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN626917 Genomic DNA. Translation: CEH26932.1.
JMBU01000149 Genomic DNA. Translation: KDA08569.1.
JPNA01000023 Genomic DNA. Translation: KFA42816.1.
JOVN01000001 Genomic DNA. Translation: KFL14526.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
KDA08569; KDA08569; DA92_03705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP007454 Genomic DNA. Translation: AHM70293.1.
CP007539 Genomic DNA. Translation: AHW65763.1.
CP007690 Genomic DNA. Translation: AIA28639.1.
CP007447 Genomic DNA. Translation: AID40832.1.
CP007499 Genomic DNA. Translation: AIL58650.1.
CP010295 Genomic DNA. Translation: AJC29525.1.
CP010296 Genomic DNA. Translation: AJC32371.1.
CP010297 Genomic DNA. Translation: AJC35214.1.
CP010298 Genomic DNA. Translation: AJC38064.1.
CP010299 Genomic DNA. Translation: AJC40902.1.
CP010300 Genomic DNA. Translation: AJC43748.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN626917 Genomic DNA. Translation: CEH26932.1.
JMBU01000149 Genomic DNA. Translation: KDA08569.1.
JPNA01000023 Genomic DNA. Translation: KFA42816.1.
JOVN01000001 Genomic DNA. Translation: KFL14526.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49001N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
KDA08569; KDA08569; DA92_03705.

Miscellaneous databases

EvolutionaryTraceiO85142.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus."
    Xiong A., Jayaswal R.K.
    J. Bacteriol. 180:4024-4029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RN450Imported.
  2. "Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912."
    Kuroda M., Hayashi H., Ohta T.
    Microbiol. Immunol. 43:115-125(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 912Imported.
  3. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
    Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
    J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
  4. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
    Arunkumar A.I., Campanello G.C., Giedroc D.P.
    Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "First report of a sequence type 239 vancomycin-intermediate Staphylococcus aureus isolate in Mainland China."
    Zhang X., Hu Q., Yuan W., Shang W., Cheng H., Yuan J., Zhu J., Hu Z., Li S., Chen W., Hu X., Rao X.
    Diagn. Microbiol. Infect. Dis. 77:64-68(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: XN108Imported.
  6. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
    Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
    J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
  7. "Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
    Parker D., Narechania A., Sebra R., Deikus G., Larussa S., Ryan C., Smith H., Prince A., Mathema B., Ratner A.J., Kreiswirth B., Planet P.J.
    Genome Announc. 2:e00284-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 502AImported.
  8. "Complete Genome Sequence of Staphylococcus aureus XN108, an ST239-MRSA-SCCmec III Strain with Intermediate Vancomycin Resistance Isolated in Mainland China."
    Zhang X., Xu X., Yuan W., Hu Q., Shang W., Hu X., Tong Y., Rao X.
    Genome Announc. 2:e00449-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: XN108Imported.
  9. "Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element."
    Benson M.A., Ohneck E.A., Ryan C., Alonzo F.III., Smith H., Narechania A., Kolokotronis S.O., Satola S.W., Uhlemann A.C., Sebra R., Deikus G., Shopsin B., Planet P.J., Torres V.J.
    Mol. Microbiol. 93:664-681(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2395 USA500Imported.
  10. "Genome sequence of Bacterial Interference Strain Staphylococcus aureus 502A."
    Parker D., Narechania A., Sebra R., Planet P.J.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Genome sequence of Staphylococcus aureus NRS 100."
    Sichtig H., Utter B., Tallon L.J., Deshong S.Lisa., Sengamalay N., Nagaraj S., McCracken C.L., Daugherty S.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRS 100Imported.
  12. "Draft genomes of heterogeneous vancomycin-intermediate Staphylococcus aureus strain MM66 and a MM66 variant selected for increased vancomycin susceptibility."
    Matyi S.A., Nelson M., Hoyt P.R., Gustafson J.E.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MM66RVI-4Imported.
  13. "Complete genome sequences of two prolific biofilm forming Staphylococcus aureus isolates, belonging to EMRSA15 and USA300 clonal lineages."
    Sabirova J., Britto Xavier B., Goossens H., Malhotra-Kumar S.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UA-S391_USA300Imported.
  14. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CDC 73-57501Imported.
  15. "Monitoring Infection-Based Transcriptomic Changes in Staphylococcus aureus using RNA-seq."
    Brady R., Su Q., Daugherty S., Creasy H.H., Ott S., Sengamalay N., Fraser C., Burns D.L., Bruno V.M.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brady-SAP149Imported.
  16. Xu Yijuan
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SAU060112Imported.
  17. Manzoor Shahid, Zubair Saima
    Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ILRI_Eymole1/1Imported.
  18. "Whole Genome Sequence for Methicillin Resistant Staphylococcus aureus strain (MRSA): ATCC BAA-1680."
    Daum L.T., Bhattacharyya S., Bumah V., Meyers D.M., Enwemeka C.S.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 29b_MRSAImported, 31b_MRSAImported and 33bImported.
  19. "Whole Genome Sequence for Methicillin Resistant Staphylococcus aureus strain (MRSA): ATCC BAA-1680."
    Daum L.T., Bhattacharyya S., Bumah V., Meyers D.M., Enwemeka C.S.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 25b_MRSAImported, 26b_MRSAImported and 27b_MRSAImported.

Entry informationi

Entry nameiO85142_STAAU
AccessioniPrimary (citable) accession number: O85142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.