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Protein
Submitted name:

ArsR family transcriptional regulator

Gene

rzcA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc
Metal bindingi86 – 861Zinc; via pros nitrogen
Metal bindingi97 – 971Zinc; via pros nitrogen
Metal bindingi100 – 1001Zinc; via tele nitrogen

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ArsR family transcriptional regulatorImported
Submitted name:
CzrA proteinImported
Submitted name:
HTH-type transcriptional repressor CzrAImported
Submitted name:
Repressor proteinImported
Submitted name:
Zn(II) or Co(II)-specific transcriptional repressor proteinImported
Gene namesi
Name:rzcAImported
Synonyms:CzrAImported, czrAImported
ORF Names:ERS445051_02103Imported, ERS445052_01256Imported, JN533_14930Imported, RC78_13550Imported, RC80_06895Imported, RM29_11540Imported, SAU060112_60086Imported
Encoded oniPlasmid 2Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000031101 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-49001N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ProteinModelPortaliO85142.
SMRiO85142. Positions 6-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN
60 70 80 90 100
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH

PKESGL
Length:106
Mass (Da):11,989
Last modified:November 1, 1998 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP010295 Genomic DNA. Translation: AJC29525.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN626917 Genomic DNA. Translation: CEH26932.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
JSYA01000018 Genomic DNA. Translation: KII20603.1.
JYFO01000025 Genomic DNA. Translation: KIX70655.1.
JYFP01000008 Genomic DNA. Translation: KIX74989.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
AIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AJC32371; AJC32371; RM30_11535.
AJC35214; AJC35214; QT38_11535.
AJC38064; AJC38064; RM31_11545.
AJC40902; AJC40902; RM27_11540.
AJC43748; AJC43748; RM28_11535.
KDA08569; KDA08569; DA92_03705.
KFA42816; KFA42816; EW35_2512.
KFL14526; KFL14526; DP18_2501.
GeneIDi23197940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
CP010295 Genomic DNA. Translation: AJC29525.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN626917 Genomic DNA. Translation: CEH26932.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
JSYA01000018 Genomic DNA. Translation: KII20603.1.
JYFO01000025 Genomic DNA. Translation: KIX70655.1.
JYFP01000008 Genomic DNA. Translation: KIX74989.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ProteinModelPortaliO85142.
SMRiO85142. Positions 6-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49001N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
AIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AJC32371; AJC32371; RM30_11535.
AJC35214; AJC35214; QT38_11535.
AJC38064; AJC38064; RM31_11545.
AJC40902; AJC40902; RM27_11540.
AJC43748; AJC43748; RM28_11535.
KDA08569; KDA08569; DA92_03705.
KFA42816; KFA42816; EW35_2512.
KFL14526; KFL14526; DP18_2501.
GeneIDi23197940.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus."
    Xiong A., Jayaswal R.K.
    J. Bacteriol. 180:4024-4029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RN450Imported.
  2. "Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912."
    Kuroda M., Hayashi H., Ohta T.
    Microbiol. Immunol. 43:115-125(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 912Imported.
  3. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
    Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
    J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
  4. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
    Arunkumar A.I., Campanello G.C., Giedroc D.P.
    Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
    Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
    J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
  6. Xu Yijuan
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SAU060112Imported.
  7. Manzoor Shahid, Zubair Saima
    Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ILRI_Eymole1/1Imported.
  8. "Genome sequencing of Staphylococcus aureus ST541."
    Moon D.C., Lim S.-K.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: K12PJN53Imported.
  9. "Genome sequence of Staphylococcus aureus strain P151."
    Tan W.-S., Ho W.-Y., Chew C.-H., Chan K.-G.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: P151Imported.
  10. "Genome sequence of Staphylococcus aureus strain P180."
    Tan W.-S., Ho W.-Y., Chew C.-H., Chan K.-G.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: P180Imported.
  11. "Whole-Genome Sequence for Methicillin-Resistant Staphylococcus aureus Strain ATCC BAA-1680."
    Daum L.T., Bumah V.V., Masson-Meyers D.S., Khubbar M., Rodriguez J.D., Fischer G.W., Enwemeka C.S., Gradus S., Bhattacharyya S.
    Genome Announc. 3:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 29b_MRSAImported.
  12. Informatics Pathogen
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCTC13435Imported and NCTC8532Imported.
    Plasmid: 2

Entry informationi

Entry nameiO85142_STAAU
AccessioniPrimary (citable) accession number: O85142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 27, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.