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Protein
Submitted name:

CzrA protein

Gene

rzcA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841ZincCombined sources
Metal bindingi86 – 861Zinc; via pros nitrogenCombined sources
Metal bindingi97 – 971Zinc; via pros nitrogenCombined sources
Metal bindingi100 – 1001Zinc; via tele nitrogenCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
CzrA proteinImported
Submitted name:
HTH-type transcriptional repressor CzrAImported
Submitted name:
Repressor proteinImported
Submitted name:
Zn(II) or Co(II)-specific transcriptional repressor proteinImported
Gene namesi
Name:rzcAImported
Synonyms:CzrAImported, czrAImported
ORF Names:ERS157365_02732Imported, ERS157366_02673Imported, ERS157367_01743Imported, ERS157368_02640Imported, ERS157369_02759Imported, ERS157370_02419Imported, ERS157371_02732Imported, ERS157372_02688Imported, ERS157373_02416Imported, ERS157374_02027Imported, ERS157376_02407Imported, ERS157379_02618Imported, ERS157380_02665Imported, ERS157381_02737Imported, ERS157382_02609Imported, ERS157383_02594Imported, ERS157384_01836Imported, ERS157385_01868Imported, ERS157386_02230Imported, ERS157387_02306Imported, ERS157388_02211Imported, ERS157389_02180Imported, ERS157390_02248Imported, ERS157391_02344Imported, ERS157393_02385Imported, ERS157394_01648Imported, ERS157395_02618Imported, ERS157409_02713Imported, ERS195389_02562Imported, ERS195391_02468Imported, ERS445051_02103Imported, ERS445052_01256Imported, SAU060112_60086Imported
Encoded oniPlasmid 2Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Interactioni

Protein-protein interaction databases

DIPiDIP-49001N.
STRINGi158878.SAV2145.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN
60 70 80 90 100
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH

PKESGL
Length:106
Mass (Da):11,989
Last modified:November 1, 1998 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
CVGX01000003 Genomic DNA. Translation: CRC31191.1.
CVHF01000003 Genomic DNA. Translation: CRC35974.1.
CVHG01000006 Genomic DNA. Translation: CRC57124.1.
CVHH01000005 Genomic DNA. Translation: CRC58547.1.
CVGZ01000005 Genomic DNA. Translation: CRC58624.1.
CVGY01000006 Genomic DNA. Translation: CRC60700.1.
CVHN01000006 Genomic DNA. Translation: CRC61900.1.
CVHA01000006 Genomic DNA. Translation: CRC63560.1.
CVGV01000008 Genomic DNA. Translation: CRC64587.1.
CVHM01000007 Genomic DNA. Translation: CRC65944.1.
CVGU01000009 Genomic DNA. Translation: CRC68146.1.
CVHC01000009 Genomic DNA. Translation: CRC69224.1.
CVHE01000011 Genomic DNA. Translation: CRC71627.1.
CVHJ01000011 Genomic DNA. Translation: CRC72642.1.
CVGW01000009 Genomic DNA. Translation: CRC74385.1.
CVHL01000013 Genomic DNA. Translation: CRC74776.1.
CVHK01000012 Genomic DNA. Translation: CRC75641.1.
CVHI01000014 Genomic DNA. Translation: CRC77719.1.
CVHO01000010 Genomic DNA. Translation: CRC85227.1.
CVHU01000009 Genomic DNA. Translation: CRC93110.1.
CVHT01000005 Genomic DNA. Translation: CRC93283.1.
CVHW01000004 Genomic DNA. Translation: CRC94241.1.
CVHX01000004 Genomic DNA. Translation: CRC97256.1.
CVHV01000011 Genomic DNA. Translation: CRD04844.1.
CVHY01000006 Genomic DNA. Translation: CRD07772.1.
CVIA01000004 Genomic DNA. Translation: CRD09360.1.
CVHZ01000011 Genomic DNA. Translation: CRD12324.1.
CVJS01000008 Genomic DNA. Translation: CRE68283.1.
CVJR01000012 Genomic DNA. Translation: CRE73452.1.
CVJT01000006 Genomic DNA. Translation: CRE85061.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
AIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AJC32371; AJC32371; RM30_11535.
AJC35214; AJC35214; QT38_11535.
AJC38064; AJC38064; RM31_11545.
AJC40902; AJC40902; RM27_11540.
AJC43748; AJC43748; RM28_11535.
KDA08569; KDA08569; DA92_03705.
KFA42816; KFA42816; EW35_2512.
KFL14526; KFL14526; DP18_2501.
GeneIDi23197940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044951 Genomic DNA. Translation: AAC32484.1.
AB016431 Genomic DNA. Translation: BAA36687.1.
CCXN01000014 Genomic DNA. Translation: CEF82294.1.
LN831049 Genomic DNA. Translation: CKH22876.1.
LN831036 Genomic DNA. Translation: CKH36863.1.
CVGX01000003 Genomic DNA. Translation: CRC31191.1.
CVHF01000003 Genomic DNA. Translation: CRC35974.1.
CVHG01000006 Genomic DNA. Translation: CRC57124.1.
CVHH01000005 Genomic DNA. Translation: CRC58547.1.
CVGZ01000005 Genomic DNA. Translation: CRC58624.1.
CVGY01000006 Genomic DNA. Translation: CRC60700.1.
CVHN01000006 Genomic DNA. Translation: CRC61900.1.
CVHA01000006 Genomic DNA. Translation: CRC63560.1.
CVGV01000008 Genomic DNA. Translation: CRC64587.1.
CVHM01000007 Genomic DNA. Translation: CRC65944.1.
CVGU01000009 Genomic DNA. Translation: CRC68146.1.
CVHC01000009 Genomic DNA. Translation: CRC69224.1.
CVHE01000011 Genomic DNA. Translation: CRC71627.1.
CVHJ01000011 Genomic DNA. Translation: CRC72642.1.
CVGW01000009 Genomic DNA. Translation: CRC74385.1.
CVHL01000013 Genomic DNA. Translation: CRC74776.1.
CVHK01000012 Genomic DNA. Translation: CRC75641.1.
CVHI01000014 Genomic DNA. Translation: CRC77719.1.
CVHO01000010 Genomic DNA. Translation: CRC85227.1.
CVHU01000009 Genomic DNA. Translation: CRC93110.1.
CVHT01000005 Genomic DNA. Translation: CRC93283.1.
CVHW01000004 Genomic DNA. Translation: CRC94241.1.
CVHX01000004 Genomic DNA. Translation: CRC97256.1.
CVHV01000011 Genomic DNA. Translation: CRD04844.1.
CVHY01000006 Genomic DNA. Translation: CRD07772.1.
CVIA01000004 Genomic DNA. Translation: CRD09360.1.
CVHZ01000011 Genomic DNA. Translation: CRD12324.1.
CVJS01000008 Genomic DNA. Translation: CRE68283.1.
CVJR01000012 Genomic DNA. Translation: CRE73452.1.
CVJT01000006 Genomic DNA. Translation: CRE85061.1.
PIRiT44366.
RefSeqiWP_000003759.1. NZ_KN050644.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1UX-ray2.00A/B/C/D1-106[»]
1R1VX-ray2.30A/B1-106[»]
2KJBNMR-A/B1-106[»]
2KJCNMR-A/B1-106[»]
2M30NMR-A/B1-106[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49001N.
STRINGi158878.SAV2145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAHM70293; AHM70293; CH52_08235.
AHW65763; AHW65763; X998_2124.
AIA28639; AIA28639; EX97_11010.
AID40832; AID40832; SAXN108_2391.
AIL58650; AIL58650; CH51_11585.
AJC29525; AJC29525; RM29_11540.
AJC32371; AJC32371; RM30_11535.
AJC35214; AJC35214; QT38_11535.
AJC38064; AJC38064; RM31_11545.
AJC40902; AJC40902; RM27_11540.
AJC43748; AJC43748; RM28_11535.
KDA08569; KDA08569; DA92_03705.
KFA42816; KFA42816; EW35_2512.
KFL14526; KFL14526; DP18_2501.
GeneIDi23197940.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus."
    Xiong A., Jayaswal R.K.
    J. Bacteriol. 180:4024-4029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RN450Imported.
  2. "Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912."
    Kuroda M., Hayashi H., Ohta T.
    Microbiol. Immunol. 43:115-125(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 912Imported.
  3. "A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins."
    Eicken C., Pennella M.A., Chen X., Koshlap K.M., VanZile M.L., Sacchettini J.C., Giedroc D.P.
    J. Mol. Biol. 333:683-695(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
  4. "Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state."
    Arunkumar A.I., Campanello G.C., Giedroc D.P.
    Proc. Natl. Acad. Sci. U.S.A. 106:18177-18182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods."
    Chakravorty D.K., Wang B., Lee C.W., Guerra A.J., Giedroc D.P., Merz K.M.
    J. Biomol. NMR 56:125-137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH ZINC.
  6. Xu Yijuan
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SAU060112Imported.
  7. Informatics Pathogen
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: E4278Imported, FL355Imported, FL357Imported, NCTC13435Imported, NCTC8532Imported, UK13136Imported and UKST63/485Imported.
    Plasmid: 2

Entry informationi

Entry nameiO85142_STAAU
AccessioniPrimary (citable) accession number: O85142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.