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O85140 (FABD_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malonyl CoA-acyl carrier protein transacylase
Short name=MCT
EC=2.3.1.39
Gene names
Name:fabD
Ordered Locus Names:STM1194
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the FabD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 309308Malonyl CoA-acyl carrier protein transacylase
PRO_0000194219

Sites

Active site921 By similarity
Active site2011 By similarity

Secondary structure

1 .................................................. 309
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O85140 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 73B4AB6EF02127DE

FASTA30932,405
        10         20         30         40         50         60 
MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ GPAEELNKTW 

        70         80         90        100        110        120 
QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV CAGVINFADA VRLVEMRGKF 

       130        140        150        160        170        180 
MQEAVPEGTG GMSAIIGLDD ASIAKACEES AEGQVVSPVN FNSPGQVVIA GHKEAVERAG 

       190        200        210        220        230        240 
AACKAAGAKR ALPLPVSVPS HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA 

       250        260        270        280        290        300 
AAIRDALVRQ LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP 


AALSAALTQ

« Hide

References

« Hide 'large scale' references
[1]"Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster."
Zhang Y., Cronan J.E. Jr.
J. Bacteriol. 180:3295-3303(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqNP_460164.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortalO85140.
SMRO85140. Positions 3-307.
ModBaseSearch...

Protein-protein interaction databases

STRING99287.STM1194.

Proteomic databases

PaxDbO85140.
PRIDEO85140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20123; AAL20123; STM1194.
GeneID1252712.
KEGGstm:STM1194.
PATRIC32380837. VBISalEnt20916_1263.

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000036503.
KOK00645.
OMAEVSGPFH.
ProtClustDBCLSK2459431.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1203-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.366.10. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000446. Mct. 1 hit.
SUPFAMSSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
TIGRFAMsTIGR00128. fabD. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO85140.

Entry information

Entry nameFABD_SALTY
AccessionPrimary (citable) accession number: O85140
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 29, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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