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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathway: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921By similarity
Active sitei201 – 2011By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1203-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:STM1194
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 309308Malonyl CoA-acyl carrier protein transacylasePRO_0000194219Add
BLAST

Proteomic databases

PaxDbiO85140.
PRIDEiO85140.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1194.

Structurei

Secondary structure

1
309
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Turni16 – 194Combined sources
Helixi20 – 256Combined sources
Helixi28 – 4013Combined sources
Helixi44 – 507Combined sources
Helixi53 – 564Combined sources
Helixi59 – 7921Combined sources
Beta strandi88 – 914Combined sources
Helixi93 – 1019Combined sources
Helixi107 – 12317Combined sources
Beta strandi129 – 1379Combined sources
Helixi140 – 15112Combined sources
Beta strandi156 – 1638Combined sources
Beta strandi166 – 1727Combined sources
Helixi173 – 18513Combined sources
Beta strandi189 – 1935Combined sources
Helixi203 – 2053Combined sources
Helixi206 – 21712Combined sources
Beta strandi228 – 2303Combined sources
Turni231 – 2344Combined sources
Helixi240 – 25011Combined sources
Helixi257 – 26610Combined sources
Beta strandi271 – 2744Combined sources
Beta strandi276 – 2794Combined sources
Helixi280 – 2889Combined sources
Beta strandi293 – 2964Combined sources
Helixi300 – 3078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortaliO85140.
SMRiO85140. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO85140.

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036503.
KOiK00645.
OMAiPVVTNVE.
OrthoDBiEOG6W19KW.
PhylomeDBiO85140.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O85140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ
60 70 80 90 100
GPAEELNKTW QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV
110 120 130 140 150
CAGVINFADA VRLVEMRGKF MQEAVPEGTG GMSAIIGLDD ASIAKACEES
160 170 180 190 200
AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS
210 220 230 240 250
HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA AAIRDALVRQ
260 270 280 290 300
LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP

AALSAALTQ
Length:309
Mass (Da):32,405
Last modified:January 23, 2007 - v3
Checksum:i73B4AB6EF02127DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqiNP_460164.1. NC_003197.1.
WP_000191343.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20123; AAL20123; STM1194.
GeneIDi1252712.
KEGGistm:STM1194.
PATRICi32380837. VBISalEnt20916_1263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqiNP_460164.1. NC_003197.1.
WP_000191343.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortaliO85140.
SMRiO85140. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1194.

Proteomic databases

PaxDbiO85140.
PRIDEiO85140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20123; AAL20123; STM1194.
GeneIDi1252712.
KEGGistm:STM1194.
PATRICi32380837. VBISalEnt20916_1263.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036503.
KOiK00645.
OMAiPVVTNVE.
OrthoDBiEOG6W19KW.
PhylomeDBiO85140.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciSENT99287:GCTI-1203-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO85140.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster."
    Zhang Y., Cronan J.E. Jr.
    J. Bacteriol. 180:3295-3303(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiFABD_SALTY
AccessioniPrimary (citable) accession number: O85140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.