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O85140

- FABD_SALTY

UniProt

O85140 - FABD_SALTY

Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921By similarity
    Active sitei201 – 2011By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1203-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fabD
    Ordered Locus Names:STM1194
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 309308Malonyl CoA-acyl carrier protein transacylasePRO_0000194219Add
    BLAST

    Proteomic databases

    PaxDbiO85140.
    PRIDEiO85140.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM1194.

    Structurei

    Secondary structure

    1
    309
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Turni16 – 194
    Helixi20 – 256
    Helixi28 – 4013
    Helixi44 – 507
    Helixi53 – 564
    Helixi59 – 7921
    Beta strandi88 – 914
    Helixi93 – 1019
    Helixi107 – 12317
    Beta strandi129 – 1379
    Helixi140 – 15112
    Beta strandi156 – 1638
    Beta strandi166 – 1727
    Helixi173 – 18513
    Beta strandi189 – 1935
    Helixi203 – 2053
    Helixi206 – 21712
    Beta strandi228 – 2303
    Turni231 – 2344
    Helixi240 – 25011
    Helixi257 – 26610
    Beta strandi271 – 2744
    Beta strandi276 – 2794
    Helixi280 – 2889
    Beta strandi293 – 2964
    Helixi300 – 3078

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3H0PX-ray2.00A/B1-309[»]
    ProteinModelPortaliO85140.
    SMRiO85140. Positions 3-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO85140.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036503.
    KOiK00645.
    OMAiIWRVWQE.
    OrthoDBiEOG6W19KW.
    PhylomeDBiO85140.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000446. Mct. 1 hit.
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O85140-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ    50
    GPAEELNKTW QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV 100
    CAGVINFADA VRLVEMRGKF MQEAVPEGTG GMSAIIGLDD ASIAKACEES 150
    AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS 200
    HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA AAIRDALVRQ 250
    LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP 300
    AALSAALTQ 309
    Length:309
    Mass (Da):32,405
    Last modified:January 23, 2007 - v3
    Checksum:i73B4AB6EF02127DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044668 Genomic DNA. Translation: AAC38649.1.
    AE006468 Genomic DNA. Translation: AAL20123.1.
    RefSeqiNP_460164.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20123; AAL20123; STM1194.
    GeneIDi1252712.
    KEGGistm:STM1194.
    PATRICi32380837. VBISalEnt20916_1263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044668 Genomic DNA. Translation: AAC38649.1 .
    AE006468 Genomic DNA. Translation: AAL20123.1 .
    RefSeqi NP_460164.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3H0P X-ray 2.00 A/B 1-309 [» ]
    ProteinModelPortali O85140.
    SMRi O85140. Positions 3-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1194.

    Proteomic databases

    PaxDbi O85140.
    PRIDEi O85140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20123 ; AAL20123 ; STM1194 .
    GeneIDi 1252712.
    KEGGi stm:STM1194.
    PATRICi 32380837. VBISalEnt20916_1263.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036503.
    KOi K00645.
    OMAi IWRVWQE.
    OrthoDBi EOG6W19KW.
    PhylomeDBi O85140.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci SENT99287:GCTI-1203-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O85140.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000446. Mct. 1 hit.
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster."
      Zhang Y., Cronan J.E. Jr.
      J. Bacteriol. 180:3295-3303(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiFABD_SALTY
    AccessioniPrimary (citable) accession number: O85140
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3