Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92By similarity1
Active sitei201By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:STM1194
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001942192 – 309Malonyl CoA-acyl carrier protein transacylaseAdd BLAST308

Proteomic databases

PaxDbiO85140.
PRIDEiO85140.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1194.

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Turni16 – 19Combined sources4
Helixi20 – 25Combined sources6
Helixi28 – 40Combined sources13
Helixi44 – 50Combined sources7
Helixi53 – 56Combined sources4
Helixi59 – 79Combined sources21
Beta strandi88 – 91Combined sources4
Helixi93 – 101Combined sources9
Helixi107 – 123Combined sources17
Beta strandi129 – 137Combined sources9
Helixi140 – 151Combined sources12
Beta strandi156 – 163Combined sources8
Beta strandi166 – 172Combined sources7
Helixi173 – 185Combined sources13
Beta strandi189 – 193Combined sources5
Helixi203 – 205Combined sources3
Helixi206 – 217Combined sources12
Beta strandi228 – 230Combined sources3
Turni231 – 234Combined sources4
Helixi240 – 250Combined sources11
Helixi257 – 266Combined sources10
Beta strandi271 – 274Combined sources4
Beta strandi276 – 279Combined sources4
Helixi280 – 288Combined sources9
Beta strandi293 – 296Combined sources4
Helixi300 – 307Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortaliO85140.
SMRiO85140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO85140.

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF. Bacteria.
COG0331. LUCA.
HOGENOMiHOG000036503.
KOiK00645.
OMAiFHCALMQ.
PhylomeDBiO85140.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O85140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ
60 70 80 90 100
GPAEELNKTW QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV
110 120 130 140 150
CAGVINFADA VRLVEMRGKF MQEAVPEGTG GMSAIIGLDD ASIAKACEES
160 170 180 190 200
AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS
210 220 230 240 250
HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA AAIRDALVRQ
260 270 280 290 300
LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP

AALSAALTQ
Length:309
Mass (Da):32,405
Last modified:January 23, 2007 - v3
Checksum:i73B4AB6EF02127DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqiNP_460164.1. NC_003197.1.
WP_000191343.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20123; AAL20123; STM1194.
GeneIDi1252712.
KEGGistm:STM1194.
PATRICi32380837. VBISalEnt20916_1263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqiNP_460164.1. NC_003197.1.
WP_000191343.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortaliO85140.
SMRiO85140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1194.

Proteomic databases

PaxDbiO85140.
PRIDEiO85140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20123; AAL20123; STM1194.
GeneIDi1252712.
KEGGistm:STM1194.
PATRICi32380837. VBISalEnt20916_1263.

Phylogenomic databases

eggNOGiENOG4105CJF. Bacteria.
COG0331. LUCA.
HOGENOMiHOG000036503.
KOiK00645.
OMAiFHCALMQ.
PhylomeDBiO85140.

Enzyme and pathway databases

UniPathwayiUPA00094.

Miscellaneous databases

EvolutionaryTraceiO85140.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABD_SALTY
AccessioniPrimary (citable) accession number: O85140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.