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O85140

- FABD_SALTY

UniProt

O85140 - FABD_SALTY

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Protein
Malonyl CoA-acyl carrier protein transacylase
Gene
fabD, STM1194
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921 By similarity
Active sitei201 – 2011 By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1203-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:STM1194
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 309308Malonyl CoA-acyl carrier protein transacylase
PRO_0000194219Add
BLAST

Proteomic databases

PaxDbiO85140.
PRIDEiO85140.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1194.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85
Turni16 – 194
Helixi20 – 256
Helixi28 – 4013
Helixi44 – 507
Helixi53 – 564
Helixi59 – 7921
Beta strandi88 – 914
Helixi93 – 1019
Helixi107 – 12317
Beta strandi129 – 1379
Helixi140 – 15112
Beta strandi156 – 1638
Beta strandi166 – 1727
Helixi173 – 18513
Beta strandi189 – 1935
Helixi203 – 2053
Helixi206 – 21712
Beta strandi228 – 2303
Turni231 – 2344
Helixi240 – 25011
Helixi257 – 26610
Beta strandi271 – 2744
Beta strandi276 – 2794
Helixi280 – 2889
Beta strandi293 – 2964
Helixi300 – 3078

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H0PX-ray2.00A/B1-309[»]
ProteinModelPortaliO85140.
SMRiO85140. Positions 3-307.

Miscellaneous databases

EvolutionaryTraceiO85140.

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036503.
KOiK00645.
OMAiIWRVWQE.
OrthoDBiEOG6W19KW.
PhylomeDBiO85140.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O85140-1 [UniParc]FASTAAdd to Basket

« Hide

MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ    50
GPAEELNKTW QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV 100
CAGVINFADA VRLVEMRGKF MQEAVPEGTG GMSAIIGLDD ASIAKACEES 150
AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS 200
HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA AAIRDALVRQ 250
LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP 300
AALSAALTQ 309
Length:309
Mass (Da):32,405
Last modified:January 23, 2007 - v3
Checksum:i73B4AB6EF02127DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1.
AE006468 Genomic DNA. Translation: AAL20123.1.
RefSeqiNP_460164.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20123; AAL20123; STM1194.
GeneIDi1252712.
KEGGistm:STM1194.
PATRICi32380837. VBISalEnt20916_1263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044668 Genomic DNA. Translation: AAC38649.1 .
AE006468 Genomic DNA. Translation: AAL20123.1 .
RefSeqi NP_460164.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3H0P X-ray 2.00 A/B 1-309 [» ]
ProteinModelPortali O85140.
SMRi O85140. Positions 3-307.
ModBasei Search...

Protein-protein interaction databases

STRINGi 99287.STM1194.

Proteomic databases

PaxDbi O85140.
PRIDEi O85140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20123 ; AAL20123 ; STM1194 .
GeneIDi 1252712.
KEGGi stm:STM1194.
PATRICi 32380837. VBISalEnt20916_1263.

Phylogenomic databases

eggNOGi COG0331.
HOGENOMi HOG000036503.
KOi K00645.
OMAi IWRVWQE.
OrthoDBi EOG6W19KW.
PhylomeDBi O85140.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci SENT99287:GCTI-1203-MONOMER.

Miscellaneous databases

EvolutionaryTracei O85140.

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000446. Mct. 1 hit.
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsi TIGR00128. fabD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster."
    Zhang Y., Cronan J.E. Jr.
    J. Bacteriol. 180:3295-3303(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiFABD_SALTY
AccessioniPrimary (citable) accession number: O85140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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