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Protein

Thiol-activated cytolysin

Gene
N/A
Organism
Streptococcus suis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxinUniRule annotation
Biological processCytolysis, HemolysisUniRule annotation
LigandLipid-bindingUniRule annotation

Protein family/group databases

TCDBi1.C.12.1.8. the thiol-activated cholesterol-dependent cytolysin (cdc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-activated cytolysinUniRule annotation
OrganismiStreptococcus suisImported
Taxonomic identifieri1307 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Secreted UniRule annotation
  • Host cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host membrane, Membrane, SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27UniRule annotationAdd BLAST27
ChainiPRO_500973761628 – 497Thiol-activated cytolysinUniRule annotationAdd BLAST470

Structurei

3D structure databases

ProteinModelPortaliO85102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 490Thiol_cytolys_CInterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the thiol-activated cytolysin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane beta strandUniRule annotation

Phylogenomic databases

eggNOGiENOG4105E5P. Bacteria.
ENOG410XQPX. LUCA.

Family and domain databases

Gene3Di3.90.840.10. 2 hits.
InterProiView protein in InterPro
IPR035390. Thiol_cytolys_C.
IPR001869. Thiol_cytolysin.
IPR036363. Thiol_cytolysin_ab_sf.
IPR036359. Thiol_cytolysin_sf.
PfamiView protein in Pfam
PF17440. Thiol_cytolys_C. 1 hit.
PF01289. Thiol_cytolysin. 1 hit.
PRINTSiPR01400. TACYTOLYSIN.
SUPFAMiSSF56978. SSF56978. 1 hit.

Sequencei

Sequence statusi: Complete.

O85102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKSSHLILS SIVSLALVGV TPLSVLADSK QDINQYFQSL TYGPQEILTN
60 70 80 90 100
EGEYIDNPPA TTGMLENGRF VVLRREKKNI TNNSADIAVI DAKAANIYPG
110 120 130 140 150
ALLRADQNLL DNNPTLISIA RGDLTLSLNL PGLANGDSHT VVNSPTRSTV
160 170 180 190 200
RTGVNNLLSK WNNTYAGEYG NTQAELQYDE TMAYSMSQLK TKFGTSFEKI
210 220 230 240 250
AVPLDINFDA VNSGEKQVQI VNFKQIYYTV SVDEPESPSK LFAEGTTVED
260 270 280 290 300
LKRNGITDEV PPVYVSSVSY GRSMFIKLET SSRSTQVQAA FKAAIKGVDI
310 320 330 340 350
SGNAEYQDIL KNTSFSAYIF GGDAGSAATV VSGNIETLKK IIEEGARYGK
360 370 380 390 400
LNPGVPISYS TNFVKDNRPA QILSNSEYIE TTSTVHNSSA LTLDHSGAYV
410 420 430 440 450
AKYNITWEEV SYNEAGEEVW EPKAWDKNGV NLTSHWSETI QIPGNARNLH
460 470 480 490
VNIQECTGLA WEWWRTVYDK DLPLVGQRKI TIWGTTLYPQ YADEVIE
Length:497
Mass (Da):54,778
Last modified:November 1, 1998 - v1
Checksum:i996F56592A9E7D08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043556 Genomic DNA. Translation: AAC26107.1.
PIRiS47297.

Similar proteinsi

Entry informationi

Entry nameiO85102_STRSU
AccessioniPrimary (citable) accession number: O85102
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)