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O85066

- LEUD_BUCAP

UniProt

O85066 - LEUD_BUCAP

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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.By similarity

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.

Pathwayi

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunit (EC:4.2.1.33)
Alternative name(s):
Alpha-IPM isomerase
Short name:
IPMI
Isopropylmalate isomerase
Gene namesi
Name:leuD
Ordered Locus Names:BUsg_PL7
Encoded oniPlasmid pLeu-Sg (pBSg1)0 Publication
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Plasmid pLeu-Sg

Subcellular locationi

GO - Cellular componenti

  1. 3-isopropylmalate dehydratase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2072073-isopropylmalate dehydratase small subunitPRO_0000141803Add
BLAST

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.By similarity

Structurei

3D structure databases

ProteinModelPortaliO85066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.Curated

Phylogenomic databases

OMAiKLCLMNG.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

O85066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKFIEHTGV VVPLNISNID TDAIIPKQFL KKVNKIGFGK YLFHDWRFLD
60 70 80 90 100
KNQLKINPNF ILNKSTYKNA SILLTRENFG CGSSREHAVW SLLDYGFKVI
110 120 130 140 150
IASSFSDIFY SNSFNNKLLL IVLENEDIDY LFDLVNTKIG LSFNVSLIHK
160 170 180 190 200
KITVDNLDIP FQIDDFQRLC LVNNWDNNDL TMKIDHKIKL YEKNIFSFLL

KREKFTS
Length:207
Mass (Da):24,229
Last modified:November 1, 1998 - v1
Checksum:i0231CC4A8E795753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041836 Genomic DNA. Translation: AAD12596.1.
RefSeqiNP_047183.1. NC_001910.1.

Genome annotation databases

GeneIDi2648304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041836 Genomic DNA. Translation: AAD12596.1 .
RefSeqi NP_047183.1. NC_001910.1.

3D structure databases

ProteinModelPortali O85066.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2648304.

Phylogenomic databases

OMAi KLCLMNG.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
HAMAPi MF_01031. LeuD_type1.
InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00694. Aconitase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00171. leuD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genetic characterization of plasmids containing genes encoding enzymes of leucine biosynthesis in endosymbionts (Buchnera) of aphids."
    Baumann L., Baumann P., Moran N.A., Sandstroem J.P., Thao M.L.
    J. Mol. Evol. 48:77-85(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiLEUD_BUCAP
AccessioniPrimary (citable) accession number: O85066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3