ID   MACA1_RHOOP             Reviewed;         357 AA.
AC   O84992;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=Maleylacetate reductase 1;
DE            EC=1.3.1.32;
DE   AltName: Full=Maleylacetate reductase I;
GN   Name=macA;
OS   Rhodococcus opacus (Nocardia opaca).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=37919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1CP;
RX   MEDLINE=98324954; PubMed=9657989;
RA   Seibert V., Kourbatova E.M., Golovleva L.A., Schloemann M.;
RT   "Characterization of a maleylacetate reductase encoding region from
RT   Rhodococcus opacus 1CP.";
RL   J. Bacteriol. 180:3503-3508(1998).
CC   -!- FUNCTION: Plays a major role in the degradation of chloroaromatic
CC       compounds by channeling maleylacetate and some of its substituted
CC       derivatives into the 3-oxoadipate pathway. This enzyme converts
CC       maleylacetate and 2-chloromaleylacetate with similar efficiencies.
CC   -!- CATALYTIC ACTIVITY: 3-oxoadipate + NAD(P)(+) = 2-maleylacetate +
CC       NAD(P)H.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-chlorocatechol
CC       degradation.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; AF030176; AAC38802.1; -; Genomic_DNA.
DR   BioCyc; MetaCyc:MON-13024; -.
DR   BRENDA; 1.3.1.32; 2206.
DR   GO; GO:0018506; F:maleylacetate reductase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001670; ADH_Fe.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   PROSITE; PS00913; ADH_IRON_1; FALSE_NEG.
DR   PROSITE; PS00060; ADH_IRON_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase.
FT   CHAIN         1    357       Maleylacetate reductase 1.
FT                                /FTId=PRO_0000087847.
SQ   SEQUENCE   357 AA;  37798 MW;  05BEFE211A7249CF CRC64;
     MAERSSEFVF TGNPARVIFG AGRMRNVREE VERLGRGRVL LLGSENLREV CDQVQDLLGE
     LFVNRYDGAA MHTPVEVTDI ALAQLRTSEA DCVVAIGGGS TTGLAKALAA RTGVDQVILP
     TTYAGSEVTP VLGETVEGRK TTRSTLAVLP ETVIYDVELS KNLPVPIAVA SAVNALAHAV
     EAMYSPDANP VVDTWALEAA QALARGLRGL VSDPSCRRIR TDLLRGSWLA GMCLGSVGMA
     VHHKLCHTLG GAFGLPHAPT HTVVLPYAMS FNASEVPDVM DSLASAMNVS NAPAGVWDLI
     ADAGGPTSLA SLGLLQTDLD RAADLATEAP YRNPRQITRS GIRDLLQSAW EGNRPPE
//