O84992 (MACA1_RHOOP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maleylacetate reductase 1
EC=1.3.1.32

Alternative name(s):
Maleylacetate reductase I

Gene names

Name:

macA

Organism

Rhodococcus opacus (Nocardia opaca)

Taxonomic identifier

37919 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in the degradation of chloroaromatic compounds by channeling maleylacetate and some of its substituted derivatives into the 3-oxoadipate pathway. This enzyme converts maleylacetate and 2-chloromaleylacetate with similar efficiencies.
Catalytic activity	3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H.
Pathway	Aromatic compound metabolism; 3-chlorocatechol degradation.
Sequence similarities	Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	maleylacetate reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Maleylacetate reductase 1		PRO_0000087847

Sequences

	Sequence		Length	Mass (Da)
	O84992 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 05BEFE211A7249CF	FASTA	357	37,798
	10 20 30 40 50 60 MAERSSEFVF TGNPARVIFG AGRMRNVREE VERLGRGRVL LLGSENLREV CDQVQDLLGE 70 80 90 100 110 120 LFVNRYDGAA MHTPVEVTDI ALAQLRTSEA DCVVAIGGGS TTGLAKALAA RTGVDQVILP 130 140 150 160 170 180 TTYAGSEVTP VLGETVEGRK TTRSTLAVLP ETVIYDVELS KNLPVPIAVA SAVNALAHAV 190 200 210 220 230 240 EAMYSPDANP VVDTWALEAA QALARGLRGL VSDPSCRRIR TDLLRGSWLA GMCLGSVGMA 250 260 270 280 290 300 VHHKLCHTLG GAFGLPHAPT HTVVLPYAMS FNASEVPDVM DSLASAMNVS NAPAGVWDLI 310 320 330 340 350 ADAGGPTSLA SLGLLQTDLD RAADLATEAP YRNPRQITRS GIRDLLQSAW EGNRPPE

References

[1]	"Characterization of a maleylacetate reductase encoding region from Rhodococcus opacus 1CP." Seibert V., Kourbatova E.M., Golovleva L.A., Schloemann M. J. Bacteriol. 180:3503-3508(1998) [PubMed: 9657989] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1CP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030176 Genomic DNA. Translation: AAC38802.1.
3D structure databases
ProteinModelPortal	O84992.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-13024. MetaCyc:MONOMER-14668.
Family and domain databases
InterPro	IPR001670. ADH_Fe. [Graphical view]
Pfam	PF00465. Fe-ADH. 1 hit. [Graphical view]
PROSITE	PS00913. ADH_IRON_1. False negative. PS00060. ADH_IRON_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MACA1_RHOOP

Accession

Primary (citable) accession number: O84992

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	September 21, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program