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O84955

- BLO20_PSEAI

UniProt

O84955 - BLO20_PSEAI

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Protein

Beta-lactamase OXA-20

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-20 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa20
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 266245Beta-lactamase OXA-20PRO_0000017034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751N6-carboxylysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliO84955.
SMRiO84955. Positions 25-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2123Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O84955-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIRFLALLF SAVVLVSLGH AQEKTHESSN WGKYFSDFNA KGTIVVVDER
60 70 80 90 100
TNGNSTSVYN ESRAQQRYSP ASTFKIPHTL FALDAGAVRD EFHVFRWDGA
110 120 130 140 150
KRSFAGHNQD QNLRSAMRNS TVWVYQLFAK EIGENKARSY LEKLNYGNAD
160 170 180 190 200
PSTKSGDYWI DGNLAISANE QISILKKLYR NELPFRVEHQ RLVKDLMIVE
210 220 230 240 250
AKRDWILRAK TGWDGQMGWW VGWVEWPTGP VFFALNIDTP NRMEDLHKRE
260
AIARAILQSV NALPPN
Length:266
Mass (Da):30,449
Last modified:November 1, 1998 - v1
Checksum:i8E7270EA924F2FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024602 Genomic DNA. Translation: AAC23554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024602 Genomic DNA. Translation: AAC23554.1 .

3D structure databases

ProteinModelPortali O84955.
SMRi O84955. Positions 25-265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of OXA-20, a novel class D beta-lactamase, and its integron from Pseudomonas aeruginosa."
    Naas T., Sougakoff W., Casetta A., Nordmann P.
    Antimicrob. Agents Chemother. 42:2074-2083(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Mus.

Entry informationi

Entry nameiBLO20_PSEAI
AccessioniPrimary (citable) accession number: O84955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3