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Protein

HTH-type transcriptional regulator GalR

Gene

galR

Organism
Lactobacillus casei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor of the galactose operon. Binds galactose as an inducer (By similarity).By similarity

Pathwayi: galactose metabolism

This protein regulates the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GalR
Alternative name(s):
Galactose operon repressor
Gene namesi
Name:galR
OrganismiLactobacillus casei
Taxonomic identifieri1582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079541 – 331HTH-type transcriptional regulator GalRAdd BLAST331

Interactioni

Protein-protein interaction databases

STRINGi543734.LCABL_07330.

Structurei

3D structure databases

ProteinModelPortaliO84905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lacI-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CQ4. Bacteria.
COG1609. LUCA.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTITDIAKA AGVSIATVSR ILNYDTTLAV TPETRQRVLK TAEKLAYKPR
60 70 80 90 100
RRKRVSPQTT VALIQWRSEQ EELNDLYYLQ IQYAIEARAA SAGYHLQSLH
110 120 130 140 150
LEQLAAETTQ NVQGVIALGK YDAGEVATIK ALAQPVVFVD QNMLAFDCDS
160 170 180 190 200
VTSDYAGPIE QIIHHFQSVG INDIGFLGGV ETSRSGREQF QDVRTAAFDR
210 220 230 240 250
VMHAENLMQP AFRFIGAFTP DSGYELMKQA ITKLGDTLPH GFIVANDTMA
260 270 280 290 300
VGALRALNEA KIEVPQRVSV ISFNDVAVAK FTTPPLSTVH AATDQMGQTA
310 320 330
VELLQARIKD PKRIPRQVNF KSELIMRASS L
Length:331
Mass (Da):36,479
Last modified:November 1, 1998 - v1
Checksum:i21D5C84DB33AFD63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005933 Genomic DNA. Translation: AAC19331.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005933 Genomic DNA. Translation: AAC19331.1.

3D structure databases

ProteinModelPortaliO84905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543734.LCABL_07330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CQ4. Bacteria.
COG1609. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00214.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR_LACCA
AccessioniPrimary (citable) accession number: O84905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.