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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486MagnesiumUniRule annotation1
Metal bindingi492MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CT_842
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295801 – 695Polyribonucleotide nucleotidyltransferaseAdd BLAST695

Interactioni

Protein-protein interaction databases

STRINGi272561.CT842.

Structurei

3D structure databases

ProteinModelPortaliO84849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 612KHUniRule annotationAdd BLAST60
Domaini622 – 690S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
InParanoidiO84849.
KOiK00962.
OMAiRFMFHYN.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

O84849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFETFSVAL DKDKTLIFET GKIARQASGA VLVKMNETWV FSSACAASLS
60 70 80 90 100
EAVDFLPFRV DYQEKFSSAG RTSGGFLKRE GRPSEREILV SRLMDRSLRP
110 120 130 140 150
SFPNRLMQDI QVLSYVWSYD GKTLPDPLAI CGASAALAIS EVPQNCIVAG
160 170 180 190 200
VRVGLVGGKW VINPTRDELS ASKLDLVMAG TASAVLMIEG HCDFLTEEQV
210 220 230 240 250
LEAIAFGQTY IAKICDAIEA WQKAIGKQKN FSAVLDMPED VQNVVSDFIR
260 270 280 290 300
EKFEKALSFR DKEALEQASK ELEESVIANL VQEENSDFSL LNVKAAFKTA
310 320 330 340 350
KSNQMRALIQ DLGIRVDGRT TTEIRPISIE TPFLPRTHGS CLFTRGETQS
360 370 380 390 400
MAVCTLGGEN MAQRFEDLNG DGAARFYLQY FFPPFSVGEV GRIGSPGRRE
410 420 430 440 450
IGHGKLAEKA LSHVLPETSR FPYIIRLESN ITESNGSSSM ASVCGGCLAL
460 470 480 490 500
MDAGVPIKAP VAGIAMGLIL DRDQAIILSD ISGIEDHLGD MDFKVAGTAK
510 520 530 540 550
GITAFQMDIK IEGITHKIME QALAQAKQGR SHILNLMTQV LASPKGTVSK
560 570 580 590 600
YAPRIETMQI NTSKIATVIG PGGKQIRQII ERSGAQVDIN DDGVINIAAS
610 620 630 640 650
TQESINKAKE LIEGLTGEVE VGKVYNGRVT SIATFGVFVE VLPGKEGLCH
660 670 680 690
ISELSKQKVD NISDFVKEGD KLAVKLLSIN EKGQLKLSHK ATLED
Length:695
Mass (Da):75,499
Last modified:November 1, 1998 - v1
Checksum:iB05F36E51ABFAC0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68439.1.
PIRiE71463.
RefSeqiNP_220363.1. NC_000117.1.
WP_010725366.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68439; AAC68439; CT_842.
GeneIDi884643.
KEGGictr:CT_842.
PATRICi20381402. VBIChlTra43535_0929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68439.1.
PIRiE71463.
RefSeqiNP_220363.1. NC_000117.1.
WP_010725366.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68439; AAC68439; CT_842.
GeneIDi884643.
KEGGictr:CT_842.
PATRICi20381402. VBIChlTra43535_0929.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
InParanoidiO84849.
KOiK00962.
OMAiRFMFHYN.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_CHLTR
AccessioniPrimary (citable) accession number: O84849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1998
Last modified: February 15, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.