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O84836

- TRMB_CHLTR

UniProt

O84836 - TRMB_CHLTR

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, CT_829
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionine By similarity
Binding sitei79 – 791S-adenosyl-L-methionine By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity
Active sitei129 – 1291 By similarity
Binding sitei129 – 1291S-adenosyl-L-methionine By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei165 – 1651Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:CT_829
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT829.

Structurei

3D structure databases

ProteinModelPortaliO84836.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiIVELAMN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84836-1 [UniParc]FASTAAdd to Basket

« Hide

MKPQDLKLPY FWEERSPQIA NHVFYVPNYY SRYEEFVMPT WQELFANNGP    50
ICCELCSGNG DWVVEQALKD ASVNWIAVEK RFDRVRKIWS KMGNYRVNNL 100
LIVCGEAQTF FSHYVSDASF QKIVVNFPDP WPKFRHRKHR LFQDLFVQDM 150
MRTLVVGGQL TLATDDYNYL VNAITVMLKY LSPGLKSPHY INVKDNYGGS 200
WFENLWRSKG QEIFCTEFIK RVGI 224
Length:224
Mass (Da):26,435
Last modified:June 1, 2001 - v2
Checksum:i13F502801C936C4E
GO

Sequence cautioni

The sequence AAC68426.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68426.1. Different initiation.
PIRiE71464.
RefSeqiNP_220350.3. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68426; AAC68426; CT_829.
GeneIDi884628.
KEGGictr:CT_829.
PATRICi20381370. VBIChlTra43535_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68426.1 . Different initiation.
PIRi E71464.
RefSeqi NP_220350.3. NC_000117.1.

3D structure databases

ProteinModelPortali O84836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68426 ; AAC68426 ; CT_829 .
GeneIDi 884628.
KEGGi ctr:CT_829.
PATRICi 20381370. VBIChlTra43535_0915.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi IVELAMN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiTRMB_CHLTR
AccessioniPrimary (citable) accession number: O84836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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