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O84836

- TRMB_CHLTR

UniProt

O84836 - TRMB_CHLTR

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionineUniRule annotation
Binding sitei79 – 791S-adenosyl-L-methionineUniRule annotation
Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation
Active sitei129 – 1291By similarity
Binding sitei129 – 1291S-adenosyl-L-methionineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CT_829
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000171317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT829.

Structurei

3D structure databases

ProteinModelPortaliO84836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiO84836.
KOiK03439.
OMAiIVELAMN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84836-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPQDLKLPY FWEERSPQIA NHVFYVPNYY SRYEEFVMPT WQELFANNGP
60 70 80 90 100
ICCELCSGNG DWVVEQALKD ASVNWIAVEK RFDRVRKIWS KMGNYRVNNL
110 120 130 140 150
LIVCGEAQTF FSHYVSDASF QKIVVNFPDP WPKFRHRKHR LFQDLFVQDM
160 170 180 190 200
MRTLVVGGQL TLATDDYNYL VNAITVMLKY LSPGLKSPHY INVKDNYGGS
210 220
WFENLWRSKG QEIFCTEFIK RVGI
Length:224
Mass (Da):26,435
Last modified:June 1, 2001 - v2
Checksum:i13F502801C936C4E
GO

Sequence cautioni

The sequence AAC68426.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68426.1. Different initiation.
PIRiE71464.
RefSeqiNP_220350.3. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68426; AAC68426; CT_829.
GeneIDi884628.
KEGGictr:CT_829.
PATRICi20381370. VBIChlTra43535_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68426.1 . Different initiation.
PIRi E71464.
RefSeqi NP_220350.3. NC_000117.1.

3D structure databases

ProteinModelPortali O84836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68426 ; AAC68426 ; CT_829 .
GeneIDi 884628.
KEGGi ctr:CT_829.
PATRICi 20381370. VBIChlTra43535_0915.

Phylogenomic databases

eggNOGi COG0220.
InParanoidi O84836.
KOi K03439.
OMAi IVELAMN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiTRMB_CHLTR
AccessioniPrimary (citable) accession number: O84836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3