Skip Header

Contribute Send feedback
Read comments (?) or add your own

O84835 (RIR2_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta
EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:CT_828
OrganismChlamydia trachomatis
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190475

Sites

Active site1291 By similarity
Metal binding891Iron 1 By similarity
Metal binding1201Iron 1 By similarity
Metal binding1201Iron 2 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1931Iron 2 By similarity
Metal binding2271Iron 2 By similarity
Metal binding2301Iron 2 By similarity

Secondary structure

1 ........................................ 346
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O84835 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C0ED2D7D76238F9F

FASTA34640,516
        10         20         30         40         50         60 
MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN WLPTEIPMGK 

        70         80         90        100        110        120 
DIELWKSDRL SEDERRVILL NLGFFSTAES LVGNNIVLAI FKHVTNPEAR QYLLRQAFEE 

       130        140        150        160        170        180 
AVHTHTFLYI CESLGLDEKE IFNAYNERAA IKAKDDFQME ITGKVLDPNF RTDSVEGLQE 

       190        200        210        220        230        240 
FVKNLVGYYI IMEGIFFYSG FVMILSFHRQ NKMIGIGEQY QYILRDETIH LNFGIDLING 

       250        260        270        280        290        300 
IKEENPEIWT PELQQEIVEL IKRAVDLEIE YAQDCLPRGI LGLRASMFID YVQHIADRRL 

       310        320        330        340 
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVIEYQH AASLTW

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001273 Genomic DNA. Translation: AAC68425.1.
PIRE71466.
RefSeqNP_220349.1. NC_000117.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
ProteinModelPortalO84835.
SMRO84835. Positions 2-318.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID884627.
GenomeReviewsGene locus CT_828 in contig AE001273_GR.
KEGGctr:CT828.
PATRIC20381368. VBIChlTra43535_0914.

Phylogenomic databases

HOGENOMHBG418082.
OMAFNMYREV.
ProtClustDBPRK07209.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15784.

Family and domain databases

InterProIPR009078. Ferritin/RR-like.
IPR012348. Ribncl_red-rel.
IPR000358. Ribonucl_redctse.
[Graphical view]
Gene3DG3DSA:1.10.620.20. Ribncl_red_rel. 1 hit.
KOK00526.
PANTHERPTHR23409. Ribonucl_redctse. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
PROSITEPS00368. RIBORED_SMALL. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_CHLTR
AccessionPrimary (citable) accession number: O84835
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents