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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Iron 1By similarity1
Metal bindingi120Iron 1By similarity1
Metal bindingi120Iron 2By similarity1
Metal bindingi123Iron 1By similarity1
Active sitei129By similarity1
Metal bindingi193Iron 2By similarity1
Metal bindingi227Iron 2By similarity1
Metal bindingi230Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15784.
BRENDAi1.17.4.1. 1315.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:CT_828
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904751 – 346Ribonucleoside-diphosphate reductase subunit betaAdd BLAST346

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi272561.CT828.

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 11Combined sources6
Helixi15 – 17Combined sources3
Beta strandi20 – 22Combined sources3
Helixi37 – 47Combined sources11
Helixi53 – 55Combined sources3
Helixi59 – 66Combined sources8
Helixi72 – 98Combined sources27
Helixi101 – 103Combined sources3
Helixi107 – 134Combined sources28
Helixi138 – 142Combined sources5
Helixi144 – 147Combined sources4
Helixi149 – 161Combined sources13
Helixi163 – 166Combined sources4
Beta strandi172 – 174Combined sources3
Helixi175 – 189Combined sources15
Helixi190 – 196Combined sources7
Helixi198 – 209Combined sources12
Helixi214 – 244Combined sources31
Helixi246 – 248Combined sources3
Helixi251 – 275Combined sources25
Helixi285 – 302Combined sources18
Helixi316 – 319Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
4D8FX-ray2.20A/B/C/D1-346[»]
4D8GX-ray1.75A/B/C/D1-346[»]
4M1HX-ray1.70A/B/C/D1-346[»]
4M1IX-ray1.80A/B/C/D1-346[»]
ProteinModelPortaliO84835.
SMRiO84835.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO84835.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E05. Bacteria.
COG0208. LUCA.
InParanoidiO84835.
KOiK00526.
OMAiCNRRCQQ.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

O84835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN
60 70 80 90 100
WLPTEIPMGK DIELWKSDRL SEDERRVILL NLGFFSTAES LVGNNIVLAI
110 120 130 140 150
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAA
160 170 180 190 200
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FVKNLVGYYI IMEGIFFYSG
210 220 230 240 250
FVMILSFHRQ NKMIGIGEQY QYILRDETIH LNFGIDLING IKEENPEIWT
260 270 280 290 300
PELQQEIVEL IKRAVDLEIE YAQDCLPRGI LGLRASMFID YVQHIADRRL
310 320 330 340
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVIEYQH AASLTW
Length:346
Mass (Da):40,516
Last modified:November 1, 1998 - v1
Checksum:iC0ED2D7D76238F9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1.
PIRiE71466.
RefSeqiNP_220349.1. NC_000117.1.
WP_009872214.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68425; AAC68425; CT_828.
GeneIDi884627.
KEGGictr:CT_828.
PATRICi20381368. VBIChlTra43535_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1.
PIRiE71466.
RefSeqiNP_220349.1. NC_000117.1.
WP_009872214.1. NC_000117.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
4D8FX-ray2.20A/B/C/D1-346[»]
4D8GX-ray1.75A/B/C/D1-346[»]
4M1HX-ray1.70A/B/C/D1-346[»]
4M1IX-ray1.80A/B/C/D1-346[»]
ProteinModelPortaliO84835.
SMRiO84835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68425; AAC68425; CT_828.
GeneIDi884627.
KEGGictr:CT_828.
PATRICi20381368. VBIChlTra43535_0914.

Phylogenomic databases

eggNOGiENOG4105E05. Bacteria.
COG0208. LUCA.
InParanoidiO84835.
KOiK00526.
OMAiCNRRCQQ.

Enzyme and pathway databases

UniPathwayiUPA00326.
BioCyciMetaCyc:MONOMER-15784.
BRENDAi1.17.4.1. 1315.

Miscellaneous databases

EvolutionaryTraceiO84835.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_CHLTR
AccessioniPrimary (citable) accession number: O84835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.