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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway:iDNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1By similarity
Metal bindingi120 – 1201Iron 1By similarity
Metal bindingi120 – 1201Iron 2By similarity
Metal bindingi123 – 1231Iron 1By similarity
Active sitei129 – 1291By similarity
Metal bindingi193 – 1931Iron 2By similarity
Metal bindingi227 – 2271Iron 2By similarity
Metal bindingi230 – 2301Iron 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15784.
BRENDAi1.17.4.1. 1315.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:CT_828
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190475Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi272561.CT828.

Structurei

Secondary structure

1
346
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 116Combined sources
Helixi15 – 173Combined sources
Beta strandi20 – 223Combined sources
Helixi37 – 4711Combined sources
Helixi53 – 553Combined sources
Helixi59 – 668Combined sources
Helixi72 – 9827Combined sources
Helixi101 – 1033Combined sources
Helixi107 – 13428Combined sources
Helixi138 – 1425Combined sources
Helixi144 – 1474Combined sources
Helixi149 – 16113Combined sources
Helixi163 – 1664Combined sources
Beta strandi172 – 1743Combined sources
Helixi175 – 18915Combined sources
Helixi190 – 1967Combined sources
Helixi198 – 20912Combined sources
Helixi214 – 24431Combined sources
Helixi246 – 2483Combined sources
Helixi251 – 27525Combined sources
Helixi285 – 30218Combined sources
Helixi316 – 3194Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
4D8FX-ray2.20A/B/C/D1-346[»]
4D8GX-ray1.75A/B/C/D1-346[»]
4M1HX-ray1.70A/B/C/D1-346[»]
4M1IX-ray1.80A/B/C/D1-346[»]
ProteinModelPortaliO84835.
SMRiO84835. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO84835.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
InParanoidiO84835.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

O84835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN
60 70 80 90 100
WLPTEIPMGK DIELWKSDRL SEDERRVILL NLGFFSTAES LVGNNIVLAI
110 120 130 140 150
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAA
160 170 180 190 200
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FVKNLVGYYI IMEGIFFYSG
210 220 230 240 250
FVMILSFHRQ NKMIGIGEQY QYILRDETIH LNFGIDLING IKEENPEIWT
260 270 280 290 300
PELQQEIVEL IKRAVDLEIE YAQDCLPRGI LGLRASMFID YVQHIADRRL
310 320 330 340
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVIEYQH AASLTW
Length:346
Mass (Da):40,516
Last modified:November 1, 1998 - v1
Checksum:iC0ED2D7D76238F9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1.
PIRiE71466.
RefSeqiNP_220349.1. NC_000117.1.
WP_009872214.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68425; AAC68425; CT_828.
GeneIDi884627.
KEGGictr:CT_828.
PATRICi20381368. VBIChlTra43535_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1.
PIRiE71466.
RefSeqiNP_220349.1. NC_000117.1.
WP_009872214.1. NC_000117.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
4D8FX-ray2.20A/B/C/D1-346[»]
4D8GX-ray1.75A/B/C/D1-346[»]
4M1HX-ray1.70A/B/C/D1-346[»]
4M1IX-ray1.80A/B/C/D1-346[»]
ProteinModelPortaliO84835.
SMRiO84835. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68425; AAC68425; CT_828.
GeneIDi884627.
KEGGictr:CT_828.
PATRICi20381368. VBIChlTra43535_0914.

Phylogenomic databases

eggNOGiCOG0208.
InParanoidiO84835.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.

Enzyme and pathway databases

UniPathwayiUPA00326.
BioCyciMetaCyc:MONOMER-15784.
BRENDAi1.17.4.1. 1315.

Miscellaneous databases

EvolutionaryTraceiO84835.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiRIR2_CHLTR
AccessioniPrimary (citable) accession number: O84835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.