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O84835

- RIR2_CHLTR

UniProt

O84835 - RIR2_CHLTR

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Iron 1By similarity
    Metal bindingi120 – 1201Iron 1By similarity
    Metal bindingi120 – 1201Iron 2By similarity
    Metal bindingi123 – 1231Iron 1By similarity
    Active sitei129 – 1291By similarity
    Metal bindingi193 – 1931Iron 2By similarity
    Metal bindingi227 – 2271Iron 2By similarity
    Metal bindingi230 – 2301Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15784.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:CT_828
    OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
    Taxonomic identifieri272561 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000431: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190475Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi272561.CT828.

    Structurei

    Secondary structure

    1
    346
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 116
    Helixi15 – 173
    Beta strandi20 – 223
    Helixi37 – 4711
    Helixi53 – 553
    Helixi59 – 668
    Helixi72 – 9827
    Helixi101 – 1033
    Helixi107 – 13428
    Helixi138 – 1425
    Helixi144 – 1474
    Helixi149 – 16113
    Helixi163 – 1664
    Beta strandi172 – 1743
    Helixi175 – 18915
    Helixi190 – 1967
    Helixi198 – 20912
    Helixi214 – 24431
    Helixi246 – 2483
    Helixi251 – 27525
    Helixi285 – 30218
    Helixi316 – 3194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SYYX-ray1.70A1-346[»]
    2ANIX-ray2.00A1-346[»]
    4D8FX-ray2.20A/B/C/D1-346[»]
    4D8GX-ray1.75A/B/C/D1-346[»]
    4M1HX-ray1.70A/B/C/D1-346[»]
    4M1IX-ray1.80A/B/C/D1-346[»]
    ProteinModelPortaliO84835.
    SMRiO84835. Positions 2-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO84835.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiDWAINWI.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O84835-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN    50
    WLPTEIPMGK DIELWKSDRL SEDERRVILL NLGFFSTAES LVGNNIVLAI 100
    FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAA 150
    IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FVKNLVGYYI IMEGIFFYSG 200
    FVMILSFHRQ NKMIGIGEQY QYILRDETIH LNFGIDLING IKEENPEIWT 250
    PELQQEIVEL IKRAVDLEIE YAQDCLPRGI LGLRASMFID YVQHIADRRL 300
    ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVIEYQH AASLTW 346
    Length:346
    Mass (Da):40,516
    Last modified:November 1, 1998 - v1
    Checksum:iC0ED2D7D76238F9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68425.1.
    PIRiE71466.
    RefSeqiNP_220349.1. NC_000117.1.

    Genome annotation databases

    EnsemblBacteriaiAAC68425; AAC68425; CT_828.
    GeneIDi884627.
    KEGGictr:CT_828.
    PATRICi20381368. VBIChlTra43535_0914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68425.1 .
    PIRi E71466.
    RefSeqi NP_220349.1. NC_000117.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SYY X-ray 1.70 A 1-346 [» ]
    2ANI X-ray 2.00 A 1-346 [» ]
    4D8F X-ray 2.20 A/B/C/D 1-346 [» ]
    4D8G X-ray 1.75 A/B/C/D 1-346 [» ]
    4M1H X-ray 1.70 A/B/C/D 1-346 [» ]
    4M1I X-ray 1.80 A/B/C/D 1-346 [» ]
    ProteinModelPortali O84835.
    SMRi O84835. Positions 2-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272561.CT828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC68425 ; AAC68425 ; CT_828 .
    GeneIDi 884627.
    KEGGi ctr:CT_828.
    PATRICi 20381368. VBIChlTra43535_0914.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi DWAINWI.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci MetaCyc:MONOMER-15784.

    Miscellaneous databases

    EvolutionaryTracei O84835.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
      Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
      Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D/UW-3/Cx.

    Entry informationi

    Entry nameiRIR2_CHLTR
    AccessioniPrimary (citable) accession number: O84835
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3