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O84835

- RIR2_CHLTR

UniProt

O84835 - RIR2_CHLTR

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene
nrdB, CT_828
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1 By similarity
Metal bindingi120 – 1201Iron 1 By similarity
Metal bindingi120 – 1201Iron 2 By similarity
Metal bindingi123 – 1231Iron 1 By similarity
Active sitei129 – 1291 By similarity
Metal bindingi193 – 1931Iron 2 By similarity
Metal bindingi227 – 2271Iron 2 By similarity
Metal bindingi230 – 2301Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15784.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:CT_828
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190475Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi272561.CT828.

Structurei

Secondary structure

1
346
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 116
Helixi15 – 173
Beta strandi20 – 223
Helixi37 – 4711
Helixi53 – 553
Helixi59 – 668
Helixi72 – 9827
Helixi101 – 1033
Helixi107 – 13428
Helixi138 – 1425
Helixi144 – 1474
Helixi149 – 16113
Helixi163 – 1664
Beta strandi172 – 1743
Helixi175 – 18915
Helixi190 – 1967
Helixi198 – 20912
Helixi214 – 24431
Helixi246 – 2483
Helixi251 – 27525
Helixi285 – 30218
Helixi316 – 3194

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SYYX-ray1.70A1-346[»]
2ANIX-ray2.00A1-346[»]
4D8FX-ray2.20A/B/C/D1-346[»]
4D8GX-ray1.75A/B/C/D1-346[»]
4M1HX-ray1.70A/B/C/D1-346[»]
4M1IX-ray1.80A/B/C/D1-346[»]
ProteinModelPortaliO84835.
SMRiO84835. Positions 2-318.

Miscellaneous databases

EvolutionaryTraceiO84835.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiDWAINWI.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

O84835-1 [UniParc]FASTAAdd to Basket

« Hide

MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN    50
WLPTEIPMGK DIELWKSDRL SEDERRVILL NLGFFSTAES LVGNNIVLAI 100
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAA 150
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FVKNLVGYYI IMEGIFFYSG 200
FVMILSFHRQ NKMIGIGEQY QYILRDETIH LNFGIDLING IKEENPEIWT 250
PELQQEIVEL IKRAVDLEIE YAQDCLPRGI LGLRASMFID YVQHIADRRL 300
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVIEYQH AASLTW 346
Length:346
Mass (Da):40,516
Last modified:November 1, 1998 - v1
Checksum:iC0ED2D7D76238F9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1.
PIRiE71466.
RefSeqiNP_220349.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68425; AAC68425; CT_828.
GeneIDi884627.
KEGGictr:CT_828.
PATRICi20381368. VBIChlTra43535_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68425.1 .
PIRi E71466.
RefSeqi NP_220349.1. NC_000117.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SYY X-ray 1.70 A 1-346 [» ]
2ANI X-ray 2.00 A 1-346 [» ]
4D8F X-ray 2.20 A/B/C/D 1-346 [» ]
4D8G X-ray 1.75 A/B/C/D 1-346 [» ]
4M1H X-ray 1.70 A/B/C/D 1-346 [» ]
4M1I X-ray 1.80 A/B/C/D 1-346 [» ]
ProteinModelPortali O84835.
SMRi O84835. Positions 2-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68425 ; AAC68425 ; CT_828 .
GeneIDi 884627.
KEGGi ctr:CT_828.
PATRICi 20381368. VBIChlTra43535_0914.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi DWAINWI.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci MetaCyc:MONOMER-15784.

Miscellaneous databases

EvolutionaryTracei O84835.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiRIR2_CHLTR
AccessioniPrimary (citable) accession number: O84835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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