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Reviewed, UniProtKB/Swiss-Prot O84834 (RIR1_CHLTR)

Last modified June 16, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ribonucleoside-diphosphate reductase subunit alpha
    EC=1.17.4.1
Alternative name(s):
    Ribonucleotide reductase
Gene names
Name: nrdA
Ordered Locus Names: CT_827
OrganismChlamydia trachomatis [Complete proteome] [HAMAP]
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length1047 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family.

Contains 3 ATP-cone domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10471047Ribonucleoside-diphosphate reductase subunit alpha
PRO_0000187212

Regions

Domain9 – 111103ATP-cone 1
Domain118 – 219102ATP-cone 2
Domain237 – 32791ATP-cone 3

Sites

Active site4581Hydrogen atom transfer By similarity
Active site6701Proton acceptor By similarity
Active site6721Proton acceptor By similarity
Active site6741Proton acceptor By similarity
Active site6871Hydrogen atom transfer By similarity
Active site9901Electron transfer By similarity
Active site9911Electron transfer By similarity
Site4651Allosteric effector binding By similarity
Site4951Allosteric effector binding By similarity
Site10431Interacts with thioredoxin/glutaredoxin By similarity
Site10461Interacts with thioredoxin/glutaredoxin By similarity

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Sequences

Sequence LengthMass (Da)Tools
O84834-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: A3658C187B4668AE

FASTA1,047119,421
        10         20         30         40         50         60 
MVDLQEKQCT IVKRNGMFVP FDRNRIFQAL EAAFRDTRRI DDHMPLPEDL ESSIRSITHQ 

        70         80         90        100        110        120 
VVKEVVQKIT DGQVVTVERI QDMVESQLYV NGLQDVARDY IVYRDDRKAH RKKSWQSLSV 

       130        140        150        160        170        180 
VRRCGTVVHF NPMKISAALE KAFRATDKTE GMTPSSVREE INALTQNIVA EIEECCPQQD 

       190        200        210        220        230        240 
RRIDIEKIQD IVEQQLMVVG HYAVAKNYIL YREARARVRD NREEDGSTEK TIAEEAVEVL 

       250        260        270        280        290        300 
SKDGSTYTMT HSQLLAHLAR ACSRFPETTD AALLTDMAFA NFYSGIKESE VVLACIMAAR 

       310        320        330        340        350        360 
ANIEKEPDYA FVAAELLLDV VYKEALGKSK YAEDLEQAHR DHFKRYIAEG DTYRLNAELK 

       370        380        390        400        410        420 
HLFDLDALAD AMDLSRDLQF SYMGIQNLYD RYFNHHEGCR LETPQIFWMR VAMGLALNEQ 

       430        440        450        460        470        480 
DKTSWAITFY NLLSTFRYTP ATPTLFNSGM RHSQLSSCYL STVQDNLVNI YKVIADNAML 

       490        500        510        520        530        540 
SKWAGGIGND WTAIRATGAL IKGTNGRSQG VIPFIKVTND TAVAVNQGGK RKGAVCVYLE 

       550        560        570        580        590        600 
VWHLDYEDFL ELRKNTGDER RRAHDVNIAS WIPDLFFKRL QQKGTWTLFS PDDVPGLHDA 

       610        620        630        640        650        660 
YGEEFERLYE EYERKVDTGE IRLFKKVEAE DLWRKMLSML FETGHPWMTF KDPSNIRSAQ 

       670        680        690        700        710        720 
DHKGVVRCSN LCTEILLNCS ETETAVCNLG SINLVQHIVG DGLDEEKLSE TISIAVRMLD 

       730        740        750        760        770        780 
NVIDINFYPT KEAKEANFAH RAIGLGVMGF QDALYKLDIS YASQEAVEFA DYSSELISYY 

       790        800        810        820        830        840 
AIQASCLLAK ERGTYSSYKG SKWDRGLLPI DTIQLLANYR GEANLQMDTS SRKDWEPIRS 

       850        860        870        880        890        900 
LVKEHGMRHC QLMAIAPTAT ISNIIGVTQS IEPTYKHLFV KSNLSGEFTI PNVYLIEKLK 

       910        920        930        940        950        960 
KLGIWDADML DDLKYFDGSL LEIERIPDHL KHIFLTAFEI EPEWIIECAS RRQKWIDMGQ 

       970        980        990       1000       1010       1020 
SLNLYLAQPD GKKLSNMYLT AWKKGLKTTY YLRSSSATTV EKSFVDINKR GIQPRWMKNK 

      1030       1040 
SASAGIIVER AKKAPVCSLE EGCEACQ

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References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

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Cross-references

Sequence databases

AE001273 Genomic DNA. Translation: AAC68424.2.
PIRD71466.
RefSeqNP_220348.1.

3D structure databases

HSSPHSSP built from PDB template 3R1R based on UniProtKB P00452.
ModBaseSearch...

Genome annotation databases

GeneID884629.
GenomeReviewsGene locus CT_827 in contig AE001273_GR.
KEGGctr:CT827.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO84834.
OMAO84834. GSLWSKG.

Enzyme and pathway databases

BioCycCTRA315277:CT827-MON.
BRENDA1.17.4.1. 108.

Family and domain databases

InterProIPR005144. ATP-cone.
IPR013346. NrdE_NrdA.
IPR013509. Ribncl_Rdtase_lsu_N.
IPR000788. Ribncl_red_lg_C.
[Graphical view]
PANTHERPTHR11573. Ribncl_red_lg_C. 1 hit.
PfamPF03477. ATP-cone. 3 hits.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
PROSITEPS51161. ATP_CONE. 3 hits.
PS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameRIR1_CHLTR
AccessionPrimary (citable) accession number: O84834
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 16, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents