Reviewed,
UniProtKB/Swiss-Prot O84834 (RIR1_CHLTR)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase subunit alpha EC=1.17.4.1 Alternative name(s): Ribonucleotide reductase | ||||
| Gene names |
| ||||
| Organism | Chlamydia trachomatis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 813 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia |
Protein attributes
| Sequence length | 1047 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Pathway | |
| Subunit structure | Tetramer of two alpha and two beta subunits By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 3 ATP-cone domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Domain | Repeat |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Oxidoreductase |
| Technical term | Allosteric enzyme Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro ribonucleoside-diphosphate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1047 | 1047 | Ribonucleoside-diphosphate reductase subunit alpha | PRO_0000187212 | |||||
Regions | |||||||||
| Domain | 9 – 111 | 103 | ATP-cone 1 | ||||||
| Domain | 118 – 219 | 102 | ATP-cone 2 | ||||||
| Domain | 237 – 327 | 91 | ATP-cone 3 | ||||||
Sites | |||||||||
| Active site | 458 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 670 | 1 | Proton acceptor By similarity | ||||||
| Active site | 672 | 1 | Proton acceptor By similarity | ||||||
| Active site | 674 | 1 | Proton acceptor By similarity | ||||||
| Active site | 687 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 990 | 1 | Electron transfer By similarity | ||||||
| Active site | 991 | 1 | Electron transfer By similarity | ||||||
| Site | 465 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 495 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 1043 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
| Site | 1046 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx. |
Cross-references
Sequence databases | |
|---|---|
| AE001273 Genomic DNA. Translation: AAC68424.2. | |
| PIR | D71466. |
| RefSeq | NP_220348.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 3R1R based on UniProtKB P00452. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 884629. |
| GenomeReviews | Gene locus CT_827 in contig AE001273_GR. |
| KEGG | ctr:CT827. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O84834. |
| OMA | O84834. GSLWSKG. |
Enzyme and pathway databases | |
| BioCyc | CTRA315277:CT827-MON. |
| BRENDA | 1.17.4.1. 108. |
Family and domain databases | |
| InterPro | IPR005144. ATP-cone. IPR013346. NrdE_NrdA. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF03477. ATP-cone. 3 hits. PF02867. Ribonuc_red_lgC. 1 hit. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| TIGRFAMs | TIGR02506. NrdE_NrdA. 1 hit. |
| PROSITE | PS51161. ATP_CONE. 3 hits. PS00089. RIBORED_LARGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_CHLTR | ||||||||
| Accession | Primary (citable) accession number: O84834 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


