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O84823

- GLMS_CHLTR

UniProt

O84823 - GLMS_CHLTR

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, CT_816
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei601 – 6011For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:CT_816
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135321Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272561.CT816.

Structurei

3D structure databases

ProteinModelPortaliO84823.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini278 – 424147SIS 1
Add
BLAST
Domaini448 – 596149SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiMYDNRDS.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O84823-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFGYLGE KNAVPLVLEG LSKLEYRGYD SAGIATLVEG RLFVEKAVGP    50
VSQLCSAVSS DIHSQAAIGH TRWATHGEPS RFNAHPHVDM DASCALVHNG 100
IIENFQKLKE ELEEQGVVFS SDTDTEVIVQ LFARRYKETR DLIQSFSWTL 150
KRLQGSFACA LMHQDHPEVL LCAAHESPLI LGLGEDEVFI SSDIHAFLKY 200
SGCTQTLASG ELAVLRIGKS IETYNFELAR IQKEVRCIDH TEDSLDKKGF 250
DYYMLKELYE QPEVFERILH LTCEENGFTE SFLKGFSLDE IQSLHIVACG 300
SSYHAGYLAK YVIESIASIP VYVETASEFR YRQPYIAEHS LAILISQSGE 350
TADTLAALNE FRKLSKARVL GICNVRESAL ASRVDHCLFI EAGLEVGVAS 400
TKAFTAQLLL LILLGLRLAN HRQVIAQEDL AQAIQGLKDL PNLTRLFLDS 450
SIHDWRCRQI EETSFIFLGR RFMYPICMEA ALKLKEIAYV EANAYPAGEM 500
KHGPIALIRE GTPVIVYCGD RSVYTKTIGA IMEVKARKAY VIALAPESNR 550
DIAAVSDEQI YIPDSHDLAA PILFTIAGQI MAYTMALQRG TEVDRPRNLA 600
KSVTVE 606
Length:606
Mass (Da):67,400
Last modified:January 23, 2007 - v3
Checksum:i268123FFE5AFF6F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68413.1.
PIRiB71467.
RefSeqiNP_220337.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68413; AAC68413; CT_816.
GeneIDi884625.
KEGGictr:CT_816.
PATRICi20381342. VBIChlTra43535_0901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68413.1 .
PIRi B71467.
RefSeqi NP_220337.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84823.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT816.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68413 ; AAC68413 ; CT_816 .
GeneIDi 884625.
KEGGi ctr:CT_816.
PATRICi 20381342. VBIChlTra43535_0901.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi MYDNRDS.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiGLMS_CHLTR
AccessioniPrimary (citable) accession number: O84823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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