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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28ZincBy similarity1
Metal bindingi213ZincBy similarity1
Metal bindingi238ZincBy similarity1
Metal bindingi242ZincBy similarity1
Binding sitei273ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:CT_782
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001593791 – 477Cysteine--tRNA ligaseAdd BLAST477

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO84787.
SMRiO84787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 40"HIGH" regionAdd BLAST11
Motifi270 – 274"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8N. Bacteria.
COG0215. LUCA.
InParanoidiO84787.
KOiK01883.
OMAiHECEIAQ.

Family and domain databases

CDDicd00672. CysRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR032678. tRNA-synt_1_cat_dom.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiView protein in Pfam
PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiView protein in SMART
SM00840. DALR_2. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

O84787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFLYNTLS REKERFLPVN DPVKLYTCGP TVYDYAHIGN FRTYIFEDLL
60 70 80 90 100
KRVLLFLGYS VYHVMNITDV DDKTLAGARK KGCSLEKYCQ PYIHAFFADL
110 120 130 140 150
ETLHILKADA YPHATHYIPQ MIEAIQQLIN QGVAYIGQDQ SVYFSISQFP
160 170 180 190 200
NYGALSHLNL EELRNSARID ADEYDKDNLC DFVLWKAYDP DRDGEIFWES
210 220 230 240 250
PFGKGRPGWH LECSIMSISL LGQSLDIHAG GVDNIFPHHE NEIAQSESLS
260 270 280 290 300
HKPFVRYWLH SHHLLVDRKK MSKSLGNFFT LRDLLDQGFS GEEVRYLLLQ
310 320 330 340 350
GHYRTQLNFT QEGLHASRQS LKRLRDFICR LEDPSYPDDI IHPEVATACQ
360 370 380 390 400
SFLETFITSL TNDLNISSSL AALFDFIRKI NSSIDQHTGI QTETDSSVFS
410 420 430 440 450
KQDAQHILAL LRKIDQVLGV LPFSQPDIPE EVLLLVEQRE AARKVKNWQE
460 470
ADRLRDEILS RSFAIEDGKT GMKVKKL
Length:477
Mass (Da):54,875
Last modified:December 1, 2000 - v2
Checksum:iE6949DBF678A160F
GO

Sequence cautioni

The sequence AAC68377 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68377.1. Different initiation.
PIRiF71472.
RefSeqiNP_220301.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68377; AAC68377; CT_782.
GeneIDi884587.
KEGGictr:CT_782.
PATRICifig|272561.5.peg.859.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYC_CHLTR
AccessioniPrimary (citable) accession number: O84787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: July 5, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families