Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi431Magnesium 1By similarity1
Metal bindingi438Magnesium 1By similarity1
Metal bindingi438Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-836-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:CT_781
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526151 – 526Lysine--tRNA ligaseAdd BLAST526

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO84786
SMRiO84786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
InParanoidiO84786
KOiK04567
OMAiMMNIIPG

Family and domain databases

HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O84786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEVEYLQH EDYLYRTSKL KEIRDLGINP YPYQYTDCLE VQEIRNQFVD
60 70 80 90 100
NELGDSEAAF RKETPKVRFA GRLVLFRSMG KNSFGQILDN DAKIQVMFNR
110 120 130 140 150
DFSAVAGLAA DAGISPIKFI EKKLDLGDIL GLEGYLFFTH SGELTVLVET
160 170 180 190 200
VTLLCKSLIS LPDKHAGLAD KEIRYRKRWA DLISSEDVRK TFLTRSRILK
210 220 230 240 250
LIREYMDQQS FLEVETPILQ TIYGGAEATP FVTTLQALHA EMFLRISLEI
260 270 280 290 300
ALKKLLVGGM SRVYEIGKVF RNEGIDRTHN PEFTMIEAYA AYWDYNDVMK
310 320 330 340 350
CVENLVEYIV RALNNGETQV QYSHLKSGPQ VVDFKAPWIR MTMKESISVY
360 370 380 390 400
GGVDVDLHAD HELRKILETQ TSLPEKTYVH ASRGELIALL FDELVCDKLI
410 420 430 440 450
APHHITDHPL ETTPLCKTLR SGDETLVERF ESFCLGKELC NAYSELNDPL
460 470 480 490 500
QQRKLLEEQM RKKALNPDSE YHPIDEEFLE ALCQGMPPAG GFGIGIDRLV
510 520
MMLTDAASIR DVLFFPVMRR IEAKKD
Length:526
Mass (Da):60,106
Last modified:November 1, 1998 - v1
Checksum:iBEAE8A47DDD0D41C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68376.1
PIRiE71472
RefSeqiNP_220300.1, NC_000117.1
WP_010725342.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68376; AAC68376; CT_781
GeneIDi35550567
884579
KEGGictr:CT_781
PATRICifig|272561.5.peg.858

Similar proteinsi

Entry informationi

Entry nameiSYK_CHLTR
AccessioniPrimary (citable) accession number: O84786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health