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O84767 (MUDD_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional enzyme MurC/Ddl

Including the following 2 domains:

  1. UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
  2. D-alanine--D-alanine ligase
    EC=6.3.2.4
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
Gene names
Name:murC/ddl
Ordered Locus Names:CT_762
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length803 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00046

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00046.

Sequence similarities

In the N-terminal section; belongs to the MurCDEF family.

In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 803803Bifunctional enzyme MurC/Ddl HAMAP-Rule MF_00046
PRO_0000177916

Regions

Domain567 – 778212ATP-grasp
Nucleotide binding111 – 1177ATP Potential
Nucleotide binding600 – 65556ATP By similarity
Region1 – 446446UDP-N-acetylmuramate--alanine ligase HAMAP-Rule MF_00046
Region447 – 803357D-alanine--D-alanine ligase HAMAP-Rule MF_00046

Sites

Metal binding7321Magnesium or manganese 1 By similarity
Metal binding7451Magnesium or manganese 1 By similarity
Metal binding7451Magnesium or manganese 2 By similarity
Metal binding7471Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O84767 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 82BB523BF1F4C1C8

FASTA80389,230
        10         20         30         40         50         60 
MMKSLFYHFI GIGGIGMSAL AHVLLDRGYS VSGSDLSEGK VVEKLKNKGA EFFLGNQEEH 

        70         80         90        100        110        120 
IPEGAVVVYS SSISKKNPEF LSAKSRGNRV VHRAELLAEL AQDQISIFVT GSHGKTTVSS 

       130        140        150        160        170        180 
LITAILQEAK KNPSFAIGGL NQEGINGGSG SEYFVAEADE SDGSIRCYTP EFSVITNIDD 

       190        200        210        220        230        240 
EHLSNFEGDR ELLLASLKDF ALKTQQICWY NGDCPRLRSC LQGHTFGLDS SCDLHILSYY 

       250        260        270        280        290        300 
QEGWRLYFTA KYQDVVYADI EVQLVGMHNV LNAAAAMGIA LSLGIDEGAI RNAFRGFSGV 

       310        320        330        340        350        360 
QRRLQRKNSS ETFLFLEDYA HHPSEISCTL RAVRTAVGQR RILAIYQPHR FSRLRECIDS 

       370        380        390        400        410        420 
FPSAFKDADE VLLTEVYSAG EEAEDISYQK LAEAISQESI VKCTHIPFHE LQRHLEQSIR 

       430        440        450        460        470        480 
VHDVCVSLGA GNIVNLGEKL RDFEPQKLHL GIICGGKSCE HEISVLSAKN IAKHLSKSFY 

       490        500        510        520        530        540 
DVSYFLITRE GLWESVSSLE TAEDSGKSVF DPEIAQRLEK VDVVLPILHG PYGEDGAMQG 

       550        560        570        580        590        600 
FLETIGKPYT GPAIAFSAIA MNKVFTKRFM SDLGIPVVPY LPLTLAGWKQ EQDKWLAHIV 

       610        620        630        640        650        660 
EAFSFPIFVK SSHLGSSIGV FEVHNVIELR DAINEAFMRD NDVFVEENRL GCKEIEVSVL 

       670        680        690        700        710        720 
GDGSGAFVVA GLHERRGSGG FIDYQEKYGL SGKSSAQIVF DTDLSKEIQE QILEAADKIY 

       730        740        750        760        770        780 
RLLLGKGSCR IDFFVDEEGN FWLSEMNPIP GMTETSPFLT SFIRKGWSYE QIVHQLVIDG 

       790        800 
LQRFNQRQRL ISTSFVDQAF AIQ 

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC68357.1.
PIRA71475.
RefSeqNP_220281.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84767.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC68357; AAC68357; CT_762.
GeneID884562.
KEGGctr:CT_762.
PATRIC20381212. VBIChlTra43535_0837.

Phylogenomic databases

eggNOGCOG0773.
KOK01921.
K01924.
OMARIDFFLD.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUDD_CHLTR
AccessionPrimary (citable) accession number: O84767
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways