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Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi732Magnesium or manganese 1By similarity1
Metal bindingi745Magnesium or manganese 1By similarity1
Metal bindingi745Magnesium or manganese 2By similarity1
Metal bindingi747Magnesium or manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 117ATPSequence analysis7
Nucleotide bindingi600 – 655ATPBy similarityAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-817-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:CT_762
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779161 – 803Bifunctional enzyme MurC/DdlAdd BLAST803

Structurei

3D structure databases

ProteinModelPortaliO84767
SMRiO84767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini567 – 778ATP-graspAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 446UDP-N-acetylmuramate--alanine ligaseAdd BLAST446
Regioni447 – 803D-alanine--D-alanine ligaseAdd BLAST357

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.Curated
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU Bacteria
COG0773 LUCA
COG1181 LUCA
InParanoidiO84767
KOiK01921
K01924
OMAiINRQGLW

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
MF_00046 MurC, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR016185 PreATP-grasp_dom_sf
IPR005758 UDP-N-AcMur_Ala_ligase_murC
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
SSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
TIGR01082 murC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O84767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSLFYHFI GIGGIGMSAL AHVLLDRGYS VSGSDLSEGK VVEKLKNKGA
60 70 80 90 100
EFFLGNQEEH IPEGAVVVYS SSISKKNPEF LSAKSRGNRV VHRAELLAEL
110 120 130 140 150
AQDQISIFVT GSHGKTTVSS LITAILQEAK KNPSFAIGGL NQEGINGGSG
160 170 180 190 200
SEYFVAEADE SDGSIRCYTP EFSVITNIDD EHLSNFEGDR ELLLASLKDF
210 220 230 240 250
ALKTQQICWY NGDCPRLRSC LQGHTFGLDS SCDLHILSYY QEGWRLYFTA
260 270 280 290 300
KYQDVVYADI EVQLVGMHNV LNAAAAMGIA LSLGIDEGAI RNAFRGFSGV
310 320 330 340 350
QRRLQRKNSS ETFLFLEDYA HHPSEISCTL RAVRTAVGQR RILAIYQPHR
360 370 380 390 400
FSRLRECIDS FPSAFKDADE VLLTEVYSAG EEAEDISYQK LAEAISQESI
410 420 430 440 450
VKCTHIPFHE LQRHLEQSIR VHDVCVSLGA GNIVNLGEKL RDFEPQKLHL
460 470 480 490 500
GIICGGKSCE HEISVLSAKN IAKHLSKSFY DVSYFLITRE GLWESVSSLE
510 520 530 540 550
TAEDSGKSVF DPEIAQRLEK VDVVLPILHG PYGEDGAMQG FLETIGKPYT
560 570 580 590 600
GPAIAFSAIA MNKVFTKRFM SDLGIPVVPY LPLTLAGWKQ EQDKWLAHIV
610 620 630 640 650
EAFSFPIFVK SSHLGSSIGV FEVHNVIELR DAINEAFMRD NDVFVEENRL
660 670 680 690 700
GCKEIEVSVL GDGSGAFVVA GLHERRGSGG FIDYQEKYGL SGKSSAQIVF
710 720 730 740 750
DTDLSKEIQE QILEAADKIY RLLLGKGSCR IDFFVDEEGN FWLSEMNPIP
760 770 780 790 800
GMTETSPFLT SFIRKGWSYE QIVHQLVIDG LQRFNQRQRL ISTSFVDQAF

AIQ
Length:803
Mass (Da):89,230
Last modified:November 1, 1998 - v1
Checksum:i82BB523BF1F4C1C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68357.1
PIRiA71475
RefSeqiNP_220281.1, NC_000117.1
WP_010725335.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68357; AAC68357; CT_762
GeneIDi35550684
884562
KEGGictr:CT_762
PATRICifig|272561.5.peg.837

Similar proteinsi

Entry informationi

Entry nameiMUDD_CHLTR
AccessioniPrimary (citable) accession number: O84767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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