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O84767

- MUDD_CHLTR

UniProt

O84767 - MUDD_CHLTR

Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cell wall formation.By similarity

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi732 – 7321Magnesium or manganese 1By similarity
    Metal bindingi745 – 7451Magnesium or manganese 1By similarity
    Metal bindingi745 – 7451Magnesium or manganese 2By similarity
    Metal bindingi747 – 7471Magnesium or manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 1177ATPSequence Analysis
    Nucleotide bindingi600 – 65556ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme MurC/Ddl
    Including the following 2 domains:
    UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
    D-alanine--D-alanine ligase (EC:6.3.2.4)
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
    Gene namesi
    Name:murC/ddl
    Ordered Locus Names:CT_762
    OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
    Taxonomic identifieri272561 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000431: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Bifunctional enzyme MurC/DdlPRO_0000177916Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272561.CT762.

    Structurei

    3D structure databases

    ProteinModelPortaliO84767.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini567 – 778212ATP-graspAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 446446UDP-N-acetylmuramate--alanine ligaseAdd
    BLAST
    Regioni447 – 803357D-alanine--D-alanine ligaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the MurCDEF family.Curated
    In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    eggNOGiCOG0773.
    KOiK01921.
    K01924.
    OMAiRIDFFLD.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O84767-1 [UniParc]FASTAAdd to Basket

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    MMKSLFYHFI GIGGIGMSAL AHVLLDRGYS VSGSDLSEGK VVEKLKNKGA    50
    EFFLGNQEEH IPEGAVVVYS SSISKKNPEF LSAKSRGNRV VHRAELLAEL 100
    AQDQISIFVT GSHGKTTVSS LITAILQEAK KNPSFAIGGL NQEGINGGSG 150
    SEYFVAEADE SDGSIRCYTP EFSVITNIDD EHLSNFEGDR ELLLASLKDF 200
    ALKTQQICWY NGDCPRLRSC LQGHTFGLDS SCDLHILSYY QEGWRLYFTA 250
    KYQDVVYADI EVQLVGMHNV LNAAAAMGIA LSLGIDEGAI RNAFRGFSGV 300
    QRRLQRKNSS ETFLFLEDYA HHPSEISCTL RAVRTAVGQR RILAIYQPHR 350
    FSRLRECIDS FPSAFKDADE VLLTEVYSAG EEAEDISYQK LAEAISQESI 400
    VKCTHIPFHE LQRHLEQSIR VHDVCVSLGA GNIVNLGEKL RDFEPQKLHL 450
    GIICGGKSCE HEISVLSAKN IAKHLSKSFY DVSYFLITRE GLWESVSSLE 500
    TAEDSGKSVF DPEIAQRLEK VDVVLPILHG PYGEDGAMQG FLETIGKPYT 550
    GPAIAFSAIA MNKVFTKRFM SDLGIPVVPY LPLTLAGWKQ EQDKWLAHIV 600
    EAFSFPIFVK SSHLGSSIGV FEVHNVIELR DAINEAFMRD NDVFVEENRL 650
    GCKEIEVSVL GDGSGAFVVA GLHERRGSGG FIDYQEKYGL SGKSSAQIVF 700
    DTDLSKEIQE QILEAADKIY RLLLGKGSCR IDFFVDEEGN FWLSEMNPIP 750
    GMTETSPFLT SFIRKGWSYE QIVHQLVIDG LQRFNQRQRL ISTSFVDQAF 800
    AIQ 803
    Length:803
    Mass (Da):89,230
    Last modified:November 1, 1998 - v1
    Checksum:i82BB523BF1F4C1C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68357.1.
    PIRiA71475.
    RefSeqiNP_220281.1. NC_000117.1.
    WP_010725335.1. NC_000117.1.

    Genome annotation databases

    EnsemblBacteriaiAAC68357; AAC68357; CT_762.
    GeneIDi884562.
    KEGGictr:CT_762.
    PATRICi20381212. VBIChlTra43535_0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68357.1 .
    PIRi A71475.
    RefSeqi NP_220281.1. NC_000117.1.
    WP_010725335.1. NC_000117.1.

    3D structure databases

    ProteinModelPortali O84767.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272561.CT762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC68357 ; AAC68357 ; CT_762 .
    GeneIDi 884562.
    KEGGi ctr:CT_762.
    PATRICi 20381212. VBIChlTra43535_0837.

    Phylogenomic databases

    eggNOGi COG0773.
    KOi K01921.
    K01924.
    OMAi RIDFFLD.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
      Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
      Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D/UW-3/Cx.

    Entry informationi

    Entry nameiMUDD_CHLTR
    AccessioniPrimary (citable) accession number: O84767
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3