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Protein

Na(+)-translocating NADH-quinone reductase subunit F

Gene

nqrF

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi82Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi85Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi117Iron-sulfur (2Fe-2S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIon transport, Sodium transport, Transport
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD, Sodium, Ubiquinone

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-791-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit FUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit FUniRule annotation
Short name:
Na(+)-translocating NQR subunit FUniRule annotation
Alternative name(s):
NQR complex subunit FUniRule annotation
NQR-1 subunit FUniRule annotation
Gene namesi
Name:nqrFUniRule annotation
Synonyms:nqr6
Ordered Locus Names:CT_740
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000744921 – 431Na(+)-translocating NADH-quinone reductase subunit FAdd BLAST431

Proteomic databases

PRIDEiO84745

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84745
SMRiO84745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 1332Fe-2S ferredoxin-typeUniRule annotationAdd BLAST93
Domaini136 – 286FAD-binding FR-typeUniRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni289 – 413CatalyticAdd BLAST125

Sequence similaritiesi

Belongs to the NqrF family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JFA Bacteria
COG2871 LUCA
InParanoidiO84745
KOiK00351
OMAiYWYGGRS

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
HAMAPiMF_00430 NqrF, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR012675 Beta-grasp_dom_sf
IPR017927 Fd_Rdtase_FAD-bd
IPR010205 NqrF
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000044 Cis_Diol_DH_RD, 1 hit
SUPFAMiSSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 2 hits
TIGRFAMsiTIGR01941 nqrF, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

O84745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLSGLYSI FVASAAFCSL GLILVAVILL SRKFLIKVHP CKLKINNDDS
60 70 80 90 100
LTKTVDSGKT LLSSLLDSGI AIPSPCGGKA ACKQCKVRIT KNADEPLETD
110 120 130 140 150
RSTFSKQQLE QGWRLSCQTK VQHDLCLEVE ERYFNASSWE GTVVSNENVA
160 170 180 190 200
TFIKELVLSV DPSRPIPFKP GGYLQITVPP YKTNTSDWKQ TMDPQYYSDW
210 220 230 240 250
ETFHLFDQII DNLSLDTDSA NKAYSLASYP AELPLIKFNV RIATPPFVDQ
260 270 280 290 300
APDPTIPWGV CSSYIFSLKP GDKVMVSGPY GESFMKEDNR PVIFLIGGAG
310 320 330 340 350
SSFGRSHILD LLLNKHSDRE LTLWYGARSL KENIYQEEYE KLEKEFPNFH
360 370 380 390 400
YHLVLSQPLQ EDLDQGWDKN DPIKTNFLFK AFELGQLSHL PNPEDYLYYV
410 420 430
CGPALHNSSI LTLLDNYGVE RSSIVLDDFG S
Length:431
Mass (Da):48,513
Last modified:November 1, 1998 - v1
Checksum:i6F63E8A230B81777
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68335.1
PIRiF71476
RefSeqiNP_220259.1, NC_000117.1
WP_010725328.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68335; AAC68335; CT_740
GeneIDi35551206
884545
KEGGictr:CT_740
PATRICifig|272561.5.peg.814

Similar proteinsi

Entry informationi

Entry nameiNQRF_CHLTR
AccessioniPrimary (citable) accession number: O84745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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