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Protein

Serine--tRNA ligase

Gene

serS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).UniRule annotation

Catalytic activityi

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).UniRule annotation
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).UniRule annotation

Pathwayi: selenocysteinyl-tRNA(Sec) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-seryl-tRNA(Sec) from L-serine and tRNA(Sec).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Serine--tRNA ligase (serS)
This subpathway is part of the pathway selenocysteinyl-tRNA(Sec) biosynthesis, which is itself part of Aminoacyl-tRNA biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-seryl-tRNA(Sec) from L-serine and tRNA(Sec), the pathway selenocysteinyl-tRNA(Sec) biosynthesis and in Aminoacyl-tRNA biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei278ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei285SerineUniRule annotation1
Binding sitei384SerineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi262 – 264ATPUniRule annotation3
Nucleotide bindingi349 – 352ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-776-MONOMER
UniPathwayiUPA00906; UER00895

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--tRNA ligaseUniRule annotation (EC:6.1.1.11UniRule annotation)
Alternative name(s):
Seryl-tRNA synthetaseUniRule annotation
Short name:
SerRSUniRule annotation
Seryl-tRNA(Ser/Sec) synthetaseUniRule annotation
Gene namesi
Name:serSUniRule annotation
Ordered Locus Names:CT_729
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001220321 – 428Serine--tRNA ligaseAdd BLAST428

Interactioni

Subunit structurei

Homodimer. The tRNA molecule binds across the dimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84734
SMRiO84734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni231 – 233Serine bindingUniRule annotation3

Domaini

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGR Bacteria
COG0172 LUCA
InParanoidiO84734
KOiK01875
OMAiSPCFRRE

Family and domain databases

CDDicd00770 SerRS_core, 1 hit
HAMAPiMF_00176 Ser_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR002317 Ser-tRNA-ligase_type_1
IPR015866 Ser-tRNA-synth_1_N
IPR033729 SerRS_core
IPR010978 tRNA-bd_arm
PANTHERiPTHR43697 PTHR43697, 1 hit
PfamiView protein in Pfam
PF02403 Seryl_tRNA_N, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PIRSFiPIRSF001529 Ser-tRNA-synth_IIa, 1 hit
PRINTSiPR00981 TRNASYNTHSER
SUPFAMiSSF46589 SSF46589, 1 hit
TIGRFAMsiTIGR00414 serS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O84734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDIRLIRKE PKECESRLQK KDPAISLERL LDLDKTVRQL KADSEALLAK
60 70 80 90 100
RKVLSGQIHK AKVANENADA LIQEVNTIAD QLVAFETTLQ EQEALLEDLM
110 120 130 140 150
ARLPNYPDED VPVSPDKTGN QVIKGHGEVP TFPFPPKHHM QLNEALQILD
160 170 180 190 200
FKLPAKTTGS GWPAYCNEGV LLEWALLTYL LNKQQAHGFQ LWLPPLLVKR
210 220 230 240 250
DILFGSGQIP KFDGQYYRVE DGDQSLFLIP TAEVVLNGFH SQEILNEQDL
260 270 280 290 300
PLCYAAFTPC FRREAGAGGA HERGLVRVHQ FHKVEMFAFT TPEQEEVVYQ
310 320 330 340 350
KMLHVVEEIL SELQLPYQLS LLSTGDMSFT AKKTIDAEVW LPGQKAFYEV
360 370 380 390 400
SSISKCGDFQ ARRSETRYRD AQGKLHFVNT LNGSGLATPR LLVAILENYQ
410 420
QADGSVVIPS VLRPYMNNQE ILLPKTVR
Length:428
Mass (Da):48,315
Last modified:November 1, 1998 - v1
Checksum:iF5086AC57E469316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68324.1
PIRiD71479
RefSeqiNP_220248.1, NC_000117.1
WP_009872106.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68324; AAC68324; CT_729
GeneIDi35556988
884519
KEGGictr:CT_729
PATRICifig|272561.5.peg.802

Similar proteinsi

Entry informationi

Entry nameiSYS_CHLTR
AccessioniPrimary (citable) accession number: O84734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health