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O84716

- PCKG_CHLTR

UniProt

O84716 - PCKG_CHLTR

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn(2+) ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761SubstrateUniRule annotation
Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
Metal bindingi225 – 2251ManganeseUniRule annotation
Binding sitei225 – 2251SubstrateUniRule annotation
Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Active sitei269 – 2691UniRule annotation
Metal bindingi292 – 2921ManganeseUniRule annotation
Binding sitei383 – 3831GTPUniRule annotation
Binding sitei414 – 4141GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2736GTPUniRule annotation
Nucleotide bindingi507 – 5104GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:CT_710
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103600Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272561.CT710.

Structurei

3D structure databases

ProteinModelPortaliO84716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni381 – 3833Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
InParanoidiO84716.
KOiK01596.
OMAiDWHGKTW.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84716-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGDWISKIT HSGLKSWIEE VIALVSPDDV RLCDGSEAEY QQLCQQMQDA
60 70 80 90 100
GVMTPLNPEL HPNCFLVRSS PSDVARAEQF TFICTKTQEE AGPTNNWRDP
110 120 130 140 150
QEMRAELHAL FRECMRGRTL YIVPFCMGPL NSPFSLIGVE ITDSPYVVCS
160 170 180 190 200
MKIMTRMGAS VLAMLGSNGT FYKCLHSVGK PLAPGEKDVA WPCDPEHMRI
210 220 230 240 250
VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYLGHQQG WLAEHMLIIG
260 270 280 290 300
VTNPEGRKKY FAAAFPSACG KTNLAMLMPK LPGWKVECIG DDIAWIRPGN
310 320 330 340 350
DGRLYAVNPE FGFFGVALGT SETTNPHALA TCYADSLFTN VALTADGDVW
360 370 380 390 400
WEGKTTTPPQ GMIDWKGRTW VSGGEPAAHP NARFTAPLDH CPSLDPQWNN
410 420 430 440 450
PQGVPLEAVI FGGRRTETIP LVYEALSWEH GVMMGAGMSS TTTAAIVGEL
460 470 480 490 500
GKLRHDPFAM LPFCGYNMAA YFEHWLSFAT KGLQLPRIFG VNWFRKDEHG
510 520 530 540 550
QFIWPGFSEN LRVLEWIFRR TDGEDAIAHR TPVGYLPTAE GLNTSGLDLS
560 570 580 590
EDALRALLTV DAQGWKAEVS NIRKYCSIFG ADMPQRILEE LSRIESELK
Length:599
Mass (Da):66,245
Last modified:November 1, 1998 - v1
Checksum:i47290C1EA576E212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68305.1.
PIRiG71481.
RefSeqiNP_220229.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68305; AAC68305; CT_710.
GeneIDi884505.
KEGGictr:CT_710.
PATRICi20381090. VBIChlTra43535_0782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68305.1 .
PIRi G71481.
RefSeqi NP_220229.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84716.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68305 ; AAC68305 ; CT_710 .
GeneIDi 884505.
KEGGi ctr:CT_710.
PATRICi 20381090. VBIChlTra43535_0782.

Phylogenomic databases

eggNOGi COG1274.
InParanoidi O84716.
KOi K01596.
OMAi DWHGKTW.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiPCKG_CHLTR
AccessioniPrimary (citable) accession number: O84716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3