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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateUniRule annotation1
Metal bindingi225ManganeseUniRule annotation1
Metal bindingi245Manganese; via tele nitrogenUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei269UniRule annotation1
Metal bindingi292ManganeseUniRule annotation1
Binding sitei383GTPUniRule annotation1
Binding sitei414GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi268 – 273GTPUniRule annotation6
Nucleotide bindingi507 – 510GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:CT_710
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001036001 – 599Phosphoenolpyruvate carboxykinase [GTP]Add BLAST599

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84716.
SMRiO84716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 218Substrate bindingUniRule annotation3
Regioni381 – 383Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M. Bacteria.
COG1274. LUCA.
InParanoidiO84716.
KOiK01596.
OMAiGPTNNWV.

Family and domain databases

CDDicd00819. PEPCK_GTP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP. 1 hit.
InterProiView protein in InterPro
IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR035077. PEP_carboxykinase_GTP_C.
IPR035078. PEP_carboxykinase_GTP_N.
IPR008210. PEP_carboxykinase_N.
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiView protein in Pfam
PF00821. PEPCK_C. 1 hit.
PF17297. PEPCK_N. 1 hit.
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiView protein in PROSITE
PS00505. PEPCK_GTP. 1 hit.

Sequencei

Sequence statusi: Complete.

O84716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGDWISKIT HSGLKSWIEE VIALVSPDDV RLCDGSEAEY QQLCQQMQDA
60 70 80 90 100
GVMTPLNPEL HPNCFLVRSS PSDVARAEQF TFICTKTQEE AGPTNNWRDP
110 120 130 140 150
QEMRAELHAL FRECMRGRTL YIVPFCMGPL NSPFSLIGVE ITDSPYVVCS
160 170 180 190 200
MKIMTRMGAS VLAMLGSNGT FYKCLHSVGK PLAPGEKDVA WPCDPEHMRI
210 220 230 240 250
VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYLGHQQG WLAEHMLIIG
260 270 280 290 300
VTNPEGRKKY FAAAFPSACG KTNLAMLMPK LPGWKVECIG DDIAWIRPGN
310 320 330 340 350
DGRLYAVNPE FGFFGVALGT SETTNPHALA TCYADSLFTN VALTADGDVW
360 370 380 390 400
WEGKTTTPPQ GMIDWKGRTW VSGGEPAAHP NARFTAPLDH CPSLDPQWNN
410 420 430 440 450
PQGVPLEAVI FGGRRTETIP LVYEALSWEH GVMMGAGMSS TTTAAIVGEL
460 470 480 490 500
GKLRHDPFAM LPFCGYNMAA YFEHWLSFAT KGLQLPRIFG VNWFRKDEHG
510 520 530 540 550
QFIWPGFSEN LRVLEWIFRR TDGEDAIAHR TPVGYLPTAE GLNTSGLDLS
560 570 580 590
EDALRALLTV DAQGWKAEVS NIRKYCSIFG ADMPQRILEE LSRIESELK
Length:599
Mass (Da):66,245
Last modified:November 1, 1998 - v1
Checksum:i47290C1EA576E212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68305.1.
PIRiG71481.
RefSeqiNP_220229.1. NC_000117.1.
WP_009872086.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68305; AAC68305; CT_710.
GeneIDi884505.
KEGGictr:CT_710.
PATRICifig|272561.5.peg.782.

Similar proteinsi

Entry informationi

Entry nameiPCKG_CHLTR
AccessioniPrimary (citable) accession number: O84716
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families