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O84716

- PCKG_CHLTR

UniProt

O84716 - PCKG_CHLTR

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761SubstrateUniRule annotation
    Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
    Metal bindingi225 – 2251ManganeseUniRule annotation
    Binding sitei225 – 2251SubstrateUniRule annotation
    Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei269 – 2691UniRule annotation
    Metal bindingi292 – 2921ManganeseUniRule annotation
    Binding sitei383 – 3831GTPUniRule annotation
    Binding sitei414 – 4141GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi268 – 2736GTPUniRule annotation
    Nucleotide bindingi507 – 5104GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:CT_710
    OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
    Taxonomic identifieri272561 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103600Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272561.CT710.

    Structurei

    3D structure databases

    ProteinModelPortaliO84716.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni381 – 3833Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    KOiK01596.
    OMAiDWHGKTW.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O84716-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGDWISKIT HSGLKSWIEE VIALVSPDDV RLCDGSEAEY QQLCQQMQDA    50
    GVMTPLNPEL HPNCFLVRSS PSDVARAEQF TFICTKTQEE AGPTNNWRDP 100
    QEMRAELHAL FRECMRGRTL YIVPFCMGPL NSPFSLIGVE ITDSPYVVCS 150
    MKIMTRMGAS VLAMLGSNGT FYKCLHSVGK PLAPGEKDVA WPCDPEHMRI 200
    VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYLGHQQG WLAEHMLIIG 250
    VTNPEGRKKY FAAAFPSACG KTNLAMLMPK LPGWKVECIG DDIAWIRPGN 300
    DGRLYAVNPE FGFFGVALGT SETTNPHALA TCYADSLFTN VALTADGDVW 350
    WEGKTTTPPQ GMIDWKGRTW VSGGEPAAHP NARFTAPLDH CPSLDPQWNN 400
    PQGVPLEAVI FGGRRTETIP LVYEALSWEH GVMMGAGMSS TTTAAIVGEL 450
    GKLRHDPFAM LPFCGYNMAA YFEHWLSFAT KGLQLPRIFG VNWFRKDEHG 500
    QFIWPGFSEN LRVLEWIFRR TDGEDAIAHR TPVGYLPTAE GLNTSGLDLS 550
    EDALRALLTV DAQGWKAEVS NIRKYCSIFG ADMPQRILEE LSRIESELK 599
    Length:599
    Mass (Da):66,245
    Last modified:November 1, 1998 - v1
    Checksum:i47290C1EA576E212
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68305.1.
    PIRiG71481.
    RefSeqiNP_220229.1. NC_000117.1.

    Genome annotation databases

    EnsemblBacteriaiAAC68305; AAC68305; CT_710.
    GeneIDi884505.
    KEGGictr:CT_710.
    PATRICi20381090. VBIChlTra43535_0782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC68305.1 .
    PIRi G71481.
    RefSeqi NP_220229.1. NC_000117.1.

    3D structure databases

    ProteinModelPortali O84716.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272561.CT710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC68305 ; AAC68305 ; CT_710 .
    GeneIDi 884505.
    KEGGi ctr:CT_710.
    PATRICi 20381090. VBIChlTra43535_0782.

    Phylogenomic databases

    eggNOGi COG1274.
    KOi K01596.
    OMAi DWHGKTW.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
      Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
      Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D/UW-3/Cx.

    Entry informationi

    Entry nameiPCKG_CHLTR
    AccessioniPrimary (citable) accession number: O84716
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3