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Protein

ATP-dependent Clp protease proteolytic subunit 2

Gene

clpP2

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98NucleophileUniRule annotation1
Active sitei123UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 2UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 2UniRule annotation
Gene namesi
Name:clpP2UniRule annotation
Ordered Locus Names:CT_706
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001795361 – 203ATP-dependent Clp protease proteolytic subunit 2Add BLAST203

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84712.
SMRiO84712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
InParanoidiO84712.
KOiK01358.
OMAiLFLQSEN.

Family and domain databases

CDDicd07017. S14_ClpP_2. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiView protein in InterPro
IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiView protein in Pfam
PF00574. CLP_protease. 1 hit.
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

O84712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVPYVVED TGRGERAMDI YSRLLKDRIV MIGQEITEPL ANTVIAQLLF
60 70 80 90 100
LMSEDPTKDI QIFINSPGGY ITAGLAIYDT IRFLGCDVNT YCIGQAASMG
110 120 130 140 150
ALLLSAGTKG KRYALPHSRM MIHQPSGGII GTSADIQLQA AEILTLKKHL
160 170 180 190 200
SNILAECTGQ SVEKIIEDSE RDFFMGAEEA IAYGLIDKVI SSAKETKDKS

IAS
Length:203
Mass (Da):22,049
Last modified:November 1, 1998 - v1
Checksum:i225C775D64546558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68301.1.
PIRiC71481.
RefSeqiNP_220225.1. NC_000117.1.
WP_009872081.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68301; AAC68301; CT_706.
GeneIDi884495.
KEGGictr:CT_706.
PATRICifig|272561.5.peg.777.

Similar proteinsi

Entry informationi

Entry nameiCLPP2_CHLTR
AccessioniPrimary (citable) accession number: O84712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families