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Protein

ATP-dependent Clp protease proteolytic subunit 2

Gene

clpP2

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98NucleophileUniRule annotation1
Active sitei123UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-752-MONOMER

Protein family/group databases

MEROPSiS14.001

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 2UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 2UniRule annotation
Gene namesi
Name:clpP2UniRule annotation
Ordered Locus Names:CT_706
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001795361 – 203ATP-dependent Clp protease proteolytic subunit 2Add BLAST203

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84712
SMRiO84712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ Bacteria
COG0740 LUCA
InParanoidiO84712
KOiK01358
OMAiLFLQSEN

Family and domain databases

CDDicd07017 S14_ClpP_2, 1 hit
HAMAPiMF_00444 ClpP, 1 hit
InterProiView protein in InterPro
IPR001907 ClpP
IPR029045 ClpP/crotonase-like_dom_sf
IPR023562 ClpP/TepA
IPR033135 ClpP_His_AS
IPR018215 ClpP_Ser_AS
PANTHERiPTHR10381 PTHR10381, 1 hit
PfamiView protein in Pfam
PF00574 CLP_protease, 1 hit
PRINTSiPR00127 CLPPROTEASEP
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00382 CLP_PROTEASE_HIS, 1 hit
PS00381 CLP_PROTEASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

O84712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVPYVVED TGRGERAMDI YSRLLKDRIV MIGQEITEPL ANTVIAQLLF
60 70 80 90 100
LMSEDPTKDI QIFINSPGGY ITAGLAIYDT IRFLGCDVNT YCIGQAASMG
110 120 130 140 150
ALLLSAGTKG KRYALPHSRM MIHQPSGGII GTSADIQLQA AEILTLKKHL
160 170 180 190 200
SNILAECTGQ SVEKIIEDSE RDFFMGAEEA IAYGLIDKVI SSAKETKDKS

IAS
Length:203
Mass (Da):22,049
Last modified:November 1, 1998 - v1
Checksum:i225C775D64546558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68301.1
PIRiC71481
RefSeqiNP_220225.1, NC_000117.1
WP_009872081.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68301; AAC68301; CT_706
GeneIDi35556963
884495
KEGGictr:CT_706
PATRICifig|272561.5.peg.777

Entry informationi

Entry nameiCLPP2_CHLTR
AccessioniPrimary (citable) accession number: O84712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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