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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi114 – 1218ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:CT_701
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Protein translocase subunit SecAPRO_0000109584Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272561.CT701.

Structurei

3D structure databases

ProteinModelPortaliO84707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
InParanoidiO84707.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 2 hits.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 2 hits.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDFLKRFFG SSQERILKRF QKLVEEVNAC DEKFSSLSDD ELRKKTPQLK
60 70 80 90 100
QRYQDGESLD KLLPEAYGVV KNVCRRLAGT PVEVSGYHQQ WDMVPYDVQI
110 120 130 140 150
LGAIAMHKGF ITEMQTGEGK TLTAVMPLYL NALTGKPVHL VTVNDYLAQR
160 170 180 190 200
DCEWVGSVLR WLGLTTGVLV SGSPPEKRKA IYQCDVVYGT ASEFGFDYLR
210 220 230 240 250
DNSIATRKEE QVGRGFYFAI IDEIDSVLID EARTPLIISG PGEKHNPVYF
260 270 280 290 300
ELKDRVAELV YFQREMCNHI AIEARKVLDP FLGTDVLPKD KKVVEAISEA
310 320 330 340 350
CRALWLVSKG MPLNRVLRRV REHPDLRAMI DKWDVFYHAE QNKEQCLEKL
360 370 380 390 400
SSLYIVVDEH NNDFELTDKG MLQWIEKIGG AAEDFVMMDM GHEYALIEED
410 420 430 440 450
ATLSPADKLN RKIAVSEKDT QRKARAHGLR QLLRAHLLME KDIDYIVRDD
460 470 480 490 500
QIVIIDEHTG RPQSGRRFSE GLHQAIEAKE HVTIRKESQT FATVTLQNFF
510 520 530 540 550
RLYEKLAGMT GTAITESREF KEIYSLYVLQ VPTFKPCLRI DHNDAFYMTE
560 570 580 590 600
REKYQAIVAE IISAHRSGKP ILIGTESVEV SEKLSRILRQ NRINHTVLNA
610 620 630 640 650
KNHAQEAEII AGAGKVGAVT VATNMAGRGT DIKLDEEAVA AGGLYVIGTS
660 670 680 690 700
RHQSRRIDRQ LRGRCARLGD PGAAKFFLSF EDRLMRLFAS PKLNTLIRHF
710 720 730 740 750
RPPEGEAMSD PMFDRLIETA QKRVEGRNYT IRKHTLEYDD VMNKQRQTIY
760 770 780 790 800
AFRNDVLHAE DLFVVAKEQI EHVALALAFL ILKDAHADHC SLPKIEEWLS
810 820 830 840 850
YSFPVKLDDQ EIRRLGDVDA VADYIGDLLI EAFDVKFSAM LAEFTEIIGS
860 870 880 890 900
AANAQGICND ILRSVIISHI DEEWKVHLVD MDLLRSEVGL RSVGQKDPLI
910 920 930 940 950
EFKNESFLLF EGLIRDIRIA IVKHLFALEL SLTRSDRPDN AIPTVATAFH
960
NHDNFRPMEL TIVGEEEES
Length:969
Mass (Da):110,358
Last modified:November 1, 1998 - v1
Checksum:i2D551C2269EE86BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68296.1.
PIRiG71482.
RefSeqiNP_220220.1. NC_000117.1.
WP_010725308.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68296; AAC68296; CT_701.
GeneIDi884489.
KEGGictr:CT_701.
PATRICi20381068. VBIChlTra43535_0772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68296.1.
PIRiG71482.
RefSeqiNP_220220.1. NC_000117.1.
WP_010725308.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68296; AAC68296; CT_701.
GeneIDi884489.
KEGGictr:CT_701.
PATRICi20381068. VBIChlTra43535_0772.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
InParanoidiO84707.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 2 hits.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 2 hits.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiSECA_CHLTR
AccessioniPrimary (citable) accession number: O84707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.