SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O84638

- HEM2_CHLTR

UniProt

O84638 - HEM2_CHLTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Delta-aminolevulinic acid dehydratase
Gene
hemB, CT_633
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Schiff-base intermediate with substrate By similarity
Binding sitei209 – 2091Substrate 1 By similarity
Binding sitei221 – 2211Substrate 1 By similarity
Metal bindingi237 – 2371Magnesium By similarity
Active sitei252 – 2521Schiff-base intermediate with substrate By similarity
Binding sitei278 – 2781Substrate 2 By similarity
Binding sitei317 – 3171Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:CT_633
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Delta-aminolevulinic acid dehydratase
PRO_0000140498Add
BLAST

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi272561.CT633.

Structurei

3D structure databases

ProteinModelPortaliO84638.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
KOiK01698.
OMAiERAMIES.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84638-1 [UniParc]FASTAAdd to Basket

« Hide

MIRLPLLKRP RRNRKSAAVR SIIQETQLCS SDLIWPIFLK DGSGIREEIK    50
SMPGVYRWSL DMVSKELERL CTIGLKAVIL FPVIDANKKE QFGSYASHPY 100
NIVCKGIQAI KKSFPELCVI SDIALDPFTT SGHDGIFHNN YVINDESVRV 150
YGGIAVMHAE MGADIVAPSD MMDGRVKHIR EQMDQMGFVN TGILSYSAKY 200
ASALYGPFRD ALSSHLQSGD KRTYQMDPAN VQEALLECQL DEEEGADMVM 250
IKPAGFYLDV IVKARENTHL PVVAYQVSGE FSMIMAACLH GWLNKESVIK 300
ESLLAIKRAG ATAIISYATP WVLEWLAKDA LPFERSVL 338
Length:338
Mass (Da):37,737
Last modified:November 1, 1998 - v1
Checksum:i83E928F68EAA63FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68237.1.
PIRiE71489.
RefSeqiNP_220150.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68237; AAC68237; CT_633.
GeneIDi884414.
KEGGictr:CT_633.
PATRICi20380898. VBIChlTra43535_0693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68237.1 .
PIRi E71489.
RefSeqi NP_220150.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68237 ; AAC68237 ; CT_633 .
GeneIDi 884414.
KEGGi ctr:CT_633.
PATRICi 20380898. VBIChlTra43535_0693.

Phylogenomic databases

eggNOGi COG0113.
KOi K01698.
OMAi ERAMIES.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiHEM2_CHLTR
AccessioniPrimary (citable) accession number: O84638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi