O84620 (FOLB_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dihydroneopterin aldolase
Short name=DHNA
EC=4.1.2.25

Gene names

Name:	folB
Ordered Locus Names:	CT_614

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin By similarity.
Catalytic activity	2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.
Sequence similarities	Belongs to the DHNA family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroneopterin aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Probable dihydroneopterin aldolase		PRO_0000168268

Sequences

	Sequence		Length	Mass (Da)
	O84620 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 9755847F2DEAA3D8	FASTA	124	13,941
	10 20 30 40 50 60 MLLYRLDIAD FRVWVSIGVS EQERHYPQPV LVSLSLFFKE EPKACSTDKV SDSVCYAELV 70 80 90 100 110 120 SLIEEVATNN PCALIERLAK VLLEKIEKAL AGQVSRIDLR VSKERPPIPD LLSPVSFSIS REVP

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC68217.1.
PIR	B71494.
RefSeq	NP_220131.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84620.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884397.
GenomeReviews	Gene locus CT_614 in contig AE001273_GR.
KEGG	ctr:CT614.
PATRIC	20380852. VBIChlTra43535_0671.
Phylogenomic databases
HOGENOM	HBG402778.
OMA	EERHFKQ.
ProtClustDB	CLSK871488.
Family and domain databases
InterPro	IPR006156. Dihydroneopterin_aldolase. IPR006157. FolB_dom. [Graphical view]
KO	K01633.
Pfam	PF02152. FolB. 1 hit. [Graphical view]
SMART	SM00905. FolB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00525. FolB. 1 hit. TIGR00526. FolB_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FOLB_CHLTR

Accession

Primary (citable) accession number: O84620

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program