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Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable dihydroneopterin aldolase (folB)
  4. Folate synthesis bifunctional protein (folKP)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Folate synthesis bifunctional protein (folKP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187MagnesiumBy similarity1
Binding sitei2276-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2676-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2876-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3586-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3956-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-651-MONOMER
MetaCyc:MONOMER-18794
UniPathwayiUPA00077; UER00155
UPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC:2.7.6.3)
Short name:
HPPK
Alternative name(s):
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
PPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Ordered Locus Names:CT_613
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682411 – 450Folate synthesis bifunctional proteinAdd BLAST450

Structurei

3D structure databases

ProteinModelPortaliO84619
SMRiO84619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 441Pterin-bindingPROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 166HPPKAdd BLAST166
Regioni182 – 450DHPSAdd BLAST269
Regioni429 – 4316-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

In the C-terminal section; belongs to the DHPS family.Curated
In the N-terminal section; belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiCOG0294 LUCA
COG0801 LUCA
InParanoidiO84619
KOiK13941
OMAiSLWETEP

Family and domain databases

CDDicd00739 DHPS, 1 hit
cd00483 HPPK, 1 hit
Gene3Di3.20.20.20, 1 hit
3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000550 Hppk
IPR035907 Hppk_sf
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
SSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
TIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS00794 HPPK, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

O84619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSWNFVCLS LGSNLGNRHE HIRRAYASLK KAGIRNLKSS VILETKALLL
60 70 80 90 100
EGAPKEWDLP YFNSVVIGET QLSPDELIEE IKMIESRFGQ DASLKWGPRP
110 120 130 140 150
IDIDVLFYGD EAFSYHSDKC TIPHPKVLER PFLLSMIASL CPYRRFRLEG
160 170 180 190 200
SSCNGKTFAE LAAIYPLTEE DALGSFGSAT QIMGIVNITD NSISDTGLFL
210 220 230 240 250
EARRAAAHAE RLFAEGASII DLGAQATNPR VKDLGSVEQE WERLEPVLRL
260 270 280 290 300
LAERWGAAQQ CPDVSIDTFR PEIIRRAVEV FPIRWINDVS GGSLEMAHLA
310 320 330 340 350
KEFGLRLLIN HSCSLPPRPD CVLSYEESPI EQMLRWGESQ LEQFAQVGLD
360 370 380 390 400
TSWQVVFDPG IGFGKTPVQS MLLMDGVKQF KRVLECPVLI GHSRKSCLSM
410 420 430 440 450
LGRFNSNDRD WETIGCSVSL HDRGVDYLRV HQVEGNRRAL AAAAWAGMFV
Length:450
Mass (Da):50,313
Last modified:November 1, 1998 - v1
Checksum:i080DF5EC0D4AD521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68216.1
PIRiA71494
RefSeqiNP_220130.1, NC_000117.1
WP_009871981.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68216; AAC68216; CT_613
GeneIDi35556860
884393
KEGGictr:CT_613
PATRICifig|272561.5.peg.670

Similar proteinsi

Entry informationi

Entry nameiFOLKP_CHLTR
AccessioniPrimary (citable) accession number: O84619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health