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O84619 (FOLKP_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Folate synthesis bifunctional protein

Including the following 2 domains:

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    EC=2.7.6.3
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name=PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name=HPPK
  2. Dihydropteroate synthase
    Short name=DHPS
    EC=2.5.1.15
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
Gene names
Name:folKP
Ordered Locus Names:CT_613
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Sequence similarities

In the N-terminal section; belongs to the HPPK family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Folate synthesis bifunctional protein
PRO_0000168241

Regions

Domain180 – 441262Pterin-binding
Region1 – 166166HPPK

Sequences

Sequence LengthMass (Da)Tools
O84619 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 080DF5EC0D4AD521

FASTA45050,313
        10         20         30         40         50         60 
MTSWNFVCLS LGSNLGNRHE HIRRAYASLK KAGIRNLKSS VILETKALLL EGAPKEWDLP 

        70         80         90        100        110        120 
YFNSVVIGET QLSPDELIEE IKMIESRFGQ DASLKWGPRP IDIDVLFYGD EAFSYHSDKC 

       130        140        150        160        170        180 
TIPHPKVLER PFLLSMIASL CPYRRFRLEG SSCNGKTFAE LAAIYPLTEE DALGSFGSAT 

       190        200        210        220        230        240 
QIMGIVNITD NSISDTGLFL EARRAAAHAE RLFAEGASII DLGAQATNPR VKDLGSVEQE 

       250        260        270        280        290        300 
WERLEPVLRL LAERWGAAQQ CPDVSIDTFR PEIIRRAVEV FPIRWINDVS GGSLEMAHLA 

       310        320        330        340        350        360 
KEFGLRLLIN HSCSLPPRPD CVLSYEESPI EQMLRWGESQ LEQFAQVGLD TSWQVVFDPG 

       370        380        390        400        410        420 
IGFGKTPVQS MLLMDGVKQF KRVLECPVLI GHSRKSCLSM LGRFNSNDRD WETIGCSVSL 

       430        440        450 
HDRGVDYLRV HQVEGNRRAL AAAAWAGMFV 

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC68216.1.
PIRA71494.
RefSeqNP_220130.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84619.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC68216; AAC68216; CT_613.
GeneID884393.
KEGGctr:CT_613.
PATRIC20380850. VBIChlTra43535_0670.

Phylogenomic databases

eggNOGCOG0294.
KOK13941.
OMAMYVLDQD.
OrthoDBEOG67T5P5.
ProtClustDBCLSK871487.

Enzyme and pathway databases

UniPathwayUPA00077; UER00155.
UPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLKP_CHLTR
AccessionPrimary (citable) accession number: O84619
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways