O84619 (FOLKP_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Folate synthesis bifunctional protein

Including the following 2 domains:

1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
   EC=2.7.6.3
   Alternative name(s):
   6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
   Short name=PPPK
   7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
   Short name=HPPK
2. Dihydropteroate synthase
   Short name=DHPS
   EC=2.5.1.15
   Alternative name(s):
   Dihydropteroate pyrophosphorylase

Gene names

Name:	folKP
Ordered Locus Names:	CT_613

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate. (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
Sequence similarities	In the N-terminal section; belongs to the HPPK family. Contains 1 pterin-binding domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dihydropteroate synthase activity Inferred from electronic annotation. Source: EC kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Folate synthesis bifunctional protein		PRO_0000168241
Regions
	Domain	180 – 441	262	Pterin-binding
	Region	1 – 166	166	HPPK

Sequences

	Sequence		Length	Mass (Da)
	O84619 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 080DF5EC0D4AD521	FASTA	450	50,313
	10 20 30 40 50 60 MTSWNFVCLS LGSNLGNRHE HIRRAYASLK KAGIRNLKSS VILETKALLL EGAPKEWDLP 70 80 90 100 110 120 YFNSVVIGET QLSPDELIEE IKMIESRFGQ DASLKWGPRP IDIDVLFYGD EAFSYHSDKC 130 140 150 160 170 180 TIPHPKVLER PFLLSMIASL CPYRRFRLEG SSCNGKTFAE LAAIYPLTEE DALGSFGSAT 190 200 210 220 230 240 QIMGIVNITD NSISDTGLFL EARRAAAHAE RLFAEGASII DLGAQATNPR VKDLGSVEQE 250 260 270 280 290 300 WERLEPVLRL LAERWGAAQQ CPDVSIDTFR PEIIRRAVEV FPIRWINDVS GGSLEMAHLA 310 320 330 340 350 360 KEFGLRLLIN HSCSLPPRPD CVLSYEESPI EQMLRWGESQ LEQFAQVGLD TSWQVVFDPG 370 380 390 400 410 420 IGFGKTPVQS MLLMDGVKQF KRVLECPVLI GHSRKSCLSM LGRFNSNDRD WETIGCSVSL 430 440 450 HDRGVDYLRV HQVEGNRRAL AAAAWAGMFV

References

[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC68216.1.
PIR	A71494.
RefSeq	NP_220130.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84619.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	O84619.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884393.
GenomeReviews	Gene locus CT_613 in contig AE001273_GR.
KEGG	ctr:CT613.
PATRIC	20380850. VBIChlTra43535_0670.
Phylogenomic databases
HOGENOM	HBG665963.
OMA	KLGPHEL.
PhylomeDB	O84619.
ProtClustDB	CLSK871487.
Family and domain databases
InterPro	IPR006390. DHP_synth. IPR011005. Dihydropteroate_synth-like. IPR000550. Hppk. IPR000489. Pterin-binding. [Graphical view]
Gene3D	G3DSA:3.20.20.20. Dhdropt_synth. 1 hit. G3DSA:3.30.70.560. Hppk. 1 hit.
KO	K13941.
Pfam	PF01288. HPPK. 1 hit. PF00809. Pterin_bind. 1 hit. [Graphical view]
SUPFAM	SSF51717. DHP_synth_like. 1 hit. SSF55083. Hppk. 1 hit.
TIGRFAMs	TIGR01496. DHPS. 1 hit. TIGR01498. FolK. 1 hit.
PROSITE	PS00792. DHPS_1. 1 hit. PS00793. DHPS_2. 1 hit. PS00794. HPPK. 1 hit. PS50972. PTERIN_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FOLKP_CHLTR

Accession

Primary (citable) accession number: O84619

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program