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Reviewed, UniProtKB/Swiss-Prot O84616 (PQQCL_CHLTR)

Last modified January 19, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    PqqC-like protein
Alternative name(s):
    Chlamydia protein associating with death domains
      Short name=CADD
Gene names
Ordered Locus Names: CT_610
OrganismChlamydia trachomatis [Complete proteome] [HAMAP]
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Chlamydia specific toxin inducing apoptosis in mammalian cell lines. Ref.2

Subunit structure

Homodimer. Ref.2

Subcellular location

Secreted. Note: Secreted into the host cytoplasm. Ref.2

Developmental stage

Expressed late in the infectious cycle. Ref.2

Sequence similarities

Belongs to the pqqC family.

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Ontologies

Keywords
   Cellular componentSecreted
   LigandIron
Metal-binding
   Molecular functionToxin
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231PqqC-like protein
PRO_0000219994

Sites

Metal binding811Iron 1
Metal binding811Iron 2
Metal binding881Iron 1
Metal binding1421Iron 2
Metal binding1741Iron 1
Metal binding1781Iron 2
Metal binding1811Iron 2

Secondary structure

1 ............................. 231
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
O84616-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8AED7D2592A7FF24

FASTA23126,734
        10         20         30         40         50         60 
MMEVFMNFLD QLDLIIQNKH MLEHTFYVKW SKGELTKEQL QAYAKDYYLH IKAFPKYLSA 

        70         80         90        100        110        120 
IHSRCDDLEA RKLLLDNLMD EENGYPNHID LWKQFVFALG VTPEELEAHE PSEAAKAKVA 

       130        140        150        160        170        180 
TFMRWCTGDS LAAGVAALYS YESQIPRIAR EKIRGLTEYF GFSNPEDYAY FTEHEEADVR 

       190        200        210        220        230 
HAREEKALIE MLLKDDADKV LEASQEVTQS LYGFLDSFLD PGTCCSCHQS Y

« Hide

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References

« Hide 'large scale' references
[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
[2]"Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis."
Schwarzenbacher R., Stenner-Liewen F., Liewen H., Robinson H., Yuan H., Bossy-Wetzel E., Reed J.C., Liddington R.C.
J. Biol. Chem. 279:29320-29324(2004) [PubMed: 15087448] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, IRON-BINDING SITES.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001273 Genomic DNA. Translation: AAC68213.1.
PIRF71493.
RefSeqNP_220127.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RCWX-ray2.50A/B/C1-231[»]
ModBaseSearch...

2-D gel databases

PHCI-2DPAGEO84616.

Genome annotation databases

GeneID884390.
GenomeReviewsGene locus CT_610 in contig AE001273_GR.
KEGGctr:CT610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG293036.
OMAQQRCLKI.

Enzyme and pathway databases

BioCycCTRA315277-1:CT610-MONOMER.

Family and domain databases

InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. TENA/THI4/PQQ_synth_PqqC.
[Graphical view]
Gene3DG3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePQQCL_CHLTR
AccessionPrimary (citable) accession number: O84616
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: November 1, 1998
Last modified: January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents