Reviewed, UniProtKB/Swiss-Prot O84611 (NTPA_CHLTR)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CT_606

Organism

Chlamydia trachomatis [Complete proteome] [HAMAP]

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Nucleoside-triphosphatase		PRO_0000178152

Sequences

	Sequence		Length	Mass (Da)
	O84611-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 63C1B9D2F02758F5	FASTA	209	23,315
	10 20 30 40 50 60 MKILIASSHG YKVRETKVFL KKLGEFDIFS LVDYPSYHPP KETGETPEEN AIQKGLFAAQ 70 80 90 100 110 120 TFRCWTIADD SMLIIPALGG LPGKLSASFA GEQANDKDHR KKLLENMRLL ENTIDRSAYF 130 140 150 160 170 180 ECCVALISPF GKIFKAHASC EGTIAFEERG SSGFGYDPLF VKHDYKQTYA ELPEAIKNQV 190 200 SHRAKALVKL QPYVETVLAN HLLAGKESL

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001273 Genomic DNA. Translation: AAC68209.1.
PIR	B71493.
RefSeq	NP_220122.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	884386.
GenomeReviews	Gene locus CT_606 in contig AE001273_GR.
KEGG	ctr:CT606.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O84611.
Enzyme and pathway databases
BioCyc	CTRA315277:CT606-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLTR

Accession

Primary (citable) accession number: O84611

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	November 1, 1998
Last modified:	July 22, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)