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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143L-tryptophanUniRule annotation1
Binding sitei193ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13ATPUniRule annotation3
Nucleotide bindingi19 – 20ATPUniRule annotation2
Nucleotide bindingi155 – 157ATPUniRule annotation3
Nucleotide bindingi201 – 205ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-621-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:CT_585
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366201 – 346Tryptophan--tRNA ligaseAdd BLAST346

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84589
SMRiO84589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 20"HIGH" regionUniRule annotation9
Motifi201 – 205"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
InParanoidiO84589
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

O84589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKRVLTGD RPTGKLHLGH WIGSIMNRLQ LQNDSRYDCF FIIADLHTLT
60 70 80 90 100
TKTRKEEILQ IDNHIYDVLA DWLSVGIDPE KSAIYLQSAI PEIYELNLIF
110 120 130 140 150
SMLTPLNHIM GIPSIKEMAR NASLNEESLS HGLIGYPVLQ SADILLAKAH
160 170 180 190 200
LVPVGKDNEA HVELTRDIAK TFNRLYGEVF PEPDILQGEL TALVGTNGQG
210 220 230 240 250
KMSKSANNAI YLSDDAKTVQ EKIRKLYTDP NRIHATTPGR VEGNPLFIYH
260 270 280 290 300
DLFNPHKEEV EEFKTRYRQG CIRDVEVKAR LAEEINLFLN PFREKRSELV
310 320 330 340
AQPKFLEEAL QQGTEKMRTV ARETMEEVHD HLGLSRKWRT ILASSK
Length:346
Mass (Da):39,492
Last modified:November 1, 1998 - v1
Checksum:i5FB8C0A86CE172CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68187.1
PIRiB71496
RefSeqiNP_220100.1, NC_000117.1
WP_009871951.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68187; AAC68187; CT_585
GeneIDi35556829
884362
KEGGictr:CT_585
PATRICifig|272561.5.peg.637

Entry informationi

Entry nameiSYW_CHLTR
AccessioniPrimary (citable) accession number: O84589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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