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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).UniRule annotation

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi328ZincUniRule annotation1
Metal bindingi379Zinc; via tele nitrogenUniRule annotation1
Metal bindingi505Zinc; via pros nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-617-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Short name:
ThrRSUniRule annotation
Gene namesi
Name:thrSUniRule annotation
Ordered Locus Names:CT_581
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009631 – 635Threonine--tRNA ligaseAdd BLAST635

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84585
SMRiO84585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni237 – 528CatalyticUniRule annotationAdd BLAST292

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C22 Bacteria
COG0441 LUCA
InParanoidiO84585
KOiK01868
OMAiFYYDFAY

Family and domain databases

CDDicd00771 ThrRS_core, 1 hit
Gene3Di3.10.20.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_00184 Thr_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
IPR033728 ThrRS_core
IPR012947 tRNA_SAD
PANTHERiPTHR11451 PTHR11451, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF02824 TGS, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PF07973 tRNA_SAD, 1 hit
PRINTSiPR01047 TRNASYNTHTHR
SMARTiView protein in SMART
SM00863 tRNA_SAD, 1 hit
SUPFAMiSSF55186 SSF55186, 1 hit
TIGRFAMsiTIGR00418 thrS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O84585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHVTCNQEA FELPEGASAM DLANKMKQSH CFAGALINDQ EKDLSTTLQD
60 70 80 90 100
GDTVLFLTWD DPKGREIFLH TSAHILAQAV LRLWPSAQPT IGPVIDQGFY
110 120 130 140 150
YDFANLSISE EDFPAIEAMA KTIAEEKFPI SRQVFPDKEA ALAYFSQNPF
160 170 180 190 200
KAELIAELPE EVEISAYTQG EFLDLCRGPH LPSTAPVKAF KLLRTSSAYW
210 220 230 240 250
KGDPSRESLI RIYGVSFPTT KELKEHLHQL EEAKKRDHRV LGTKLDLFSQ
260 270 280 290 300
QTCSAGMPFF HPRGMVVWNA LVDYWKRLHQ RAGYQQIQTP QLMNRELWEI
310 320 330 340 350
SGHWENYKEN MYTLTVDEED YAIKPMNCPG CMLYYKTQLH SYREFPLRIA
360 370 380 390 400
EIGHVHRHEL SGALSGLMRV RTFHQDDAHV FLTPEQVEEE TLNILNLVSE
410 420 430 440 450
LYGTFGLEYH LELSTRPEQG TIGSDDLWEL ATKALKRALV KSQKPFIISP
460 470 480 490 500
GEGAFYGPKI DIHVKDAINR TWQCGTIQLD MFLPERFDLK YTNAQGEKST
510 520 530 540 550
PIMLHRALFG SIERFLGILI EHFKGRFPLW LSPEHVRIIT VADRHEARAQ
560 570 580 590 600
ELAKHFSQMG IIVSVDSSNE SVSKKIRNAQ NMQVNYMITI GDKELETHLL
610 620 630
AVRTRDNRVL NDIAVEQFSH VILEELRSLS LTPSL
Length:635
Mass (Da):72,601
Last modified:May 30, 2000 - v2
Checksum:i4EE6DB00C6CE6699
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68183.2
PIRiG71497
RefSeqiNP_220096.1, NC_000117.1
WP_009871947.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68183; AAC68183; CT_581
GeneIDi35556825
884359
KEGGictr:CT_581
PATRICifig|272561.5.peg.633

Similar proteinsi

Entry informationi

Entry nameiSYT_CHLTR
AccessioniPrimary (citable) accession number: O84585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health