Skip Header

Contribute Send feedback
Read comments (?) or add your own

O84547 (SYH_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:CT_543
OrganismChlamydia trachomatis
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subunit structure

Homodimer By similarity. HAMAP MF_00127

Subcellular location

Cytoplasm HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histidine--tRNA ligase HAMAP MF_00127
PRO_0000136136

Sequences

Sequence LengthMass (Da)Tools
O84547 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 9B9F59A096B8D958

FASTA42849,189
        10         20         30         40         50         60 
MSNALPKGVF DIFPYVTSPK NLWRNSSLWK RVEHAAHRIC NLYGFDEIRT PVFEKTETFL 

        70         80         90        100        110        120 
RVGEYSDIVK KEVYTFLDKK RRSLTLRPEG TAAVVRALLD HSADMRKDNK FYYILPMFRY 

       130        140        150        160        170        180 
ERQQSGRYRQ HHQFGLEAIG VRHPLRDAEV LSLLWDFYAA VGLQHMQIHV NFLGGQKTRA 

       190        200        210        220        230        240 
RYDEALREFF RKDLDRLSPL SQERYHANLL RILDSKEPED QEFIEKAPSI LDYIDDRDLS 

       250        260        270        280        290        300 
YFDAVLAQLK ALGISFAINP RLVRGLDYYT DLVFEAVTVV GEHSYALGGG GRYDELVAQS 

       310        320        330        340        350        360 
GGPSMPAFGF GVGLERVIQT LLEQGNSLST STRRLRLIPM DEQADAFCFS WANRLRNLGI 

       370        380        390        400        410        420 
ATEVDWSHKK PKLSLKDAAD QQVSFVCLLG EQELATKQFI VKDMSLHQSF SGAQQDVEQR 


LVYEVQNA

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001273 Genomic DNA. Translation: AAC68145.1.
PIRH71500.
RefSeqNP_220058.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84547.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID884320.
GenomeReviewsGene locus CT_543 in contig AE001273_GR.
KEGGctr:CT543.
PATRIC20380683. VBIChlTra43535_0588.

Phylogenomic databases

HOGENOMHBG616575.
OMAVFEWVTT.
PhylomeDBO84547.
ProtClustDBPRK00037.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_CHLTR
AccessionPrimary (citable) accession number: O84547
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents