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O84510 (RUVC_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:CT_502
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000183090

Sites

Metal binding91Magnesium By similarity
Metal binding701Magnesium By similarity
Metal binding1451Magnesium By similarity
Metal binding1481Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
O84510 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 6078DB9DE3112F94

FASTA17018,715
        10         20         30         40         50         60 
MADLIMGIDP GTLVCGYALI KVENRYHIHP HSFGKVKLSQ KLALAHRYKQ LFTEISTILQ 

        70         80         90        100        110        120 
QESPKAVVLE TQYVHKNPQS TIKLGMARGV LLLAASLQDV PVFEYAPNTA KKAAVGKGNA 

       130        140        150        160        170 
SKKQVQLMVS KLLRVPDLLA EDNEDIADAF ALAMCHAHLA PYQDLKKTLV 

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC68103.1.
PIRD71504.
RefSeqNP_220017.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT502.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC68103; AAC68103; CT_502.
GeneID884279.
KEGGctr:CT_502.
PATRIC20380595. VBIChlTra43535_0546.

Phylogenomic databases

eggNOGCOG0817.
KOK01159.
OMAYHPDEMA.
OrthoDBEOG6RG044.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_CHLTR
AccessionPrimary (citable) accession number: O84510
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families