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Protein

Translocated actin-recruiting phosphoprotein

Gene

tarP

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Appears to initiate or participate in signaling events that regulate the actin recruitment, which ultimately leads to internalization.By similarity

GO - Molecular functioni

  • SH2 domain binding Source: CAFA

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Translocated actin-recruiting phosphoprotein
Short name:
Tarp protein
Gene namesi
Name:tarP
Ordered Locus Names:CT_456
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Secreted

  • Note: Secreted via type III secretion system and translocated into host cell.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724351 – 1005Translocated actin-recruiting phosphoproteinAdd BLAST1005

Post-translational modificationi

Phosphorylated on a tyrosine on attachment to the host cell. Tyrosine phosphorylation is temporally and spatially associated with recruitment of actin to the site of chlamydial entry. Phosphorylated Tarp seems to remain cytoplasmically exposed on the inclusion membrane at one side of internalized elementary bodies for several hours after entry (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

  • SH2 domain binding Source: CAFA

Protein-protein interaction databases

STRINGi272561.CT456.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiDVIRDME.

Family and domain databases

InterProiView protein in InterPro
IPR011443. DUF1547.
PfamiView protein in Pfam
PF07577. DUF1547. 3 hits.

Sequencei

Sequence statusi: Complete.

O84462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSISGYQP TVTTSTSSTT SASGASGSLG ASSVSTTANA TVTQTANATN
60 70 80 90 100
SAATSSIQTT GETVVNYTNS ASAPNVTVST SSSSTQATAT SNKTSQAVAG
110 120 130 140 150
KITSPDTSES SETSSTSSSD HIPSDYDDVG SNSGDISNNY DDVGSNNGDI
160 170 180 190 200
SSNYDDAAAD YEPIRTTENI YESIGGSRTS GPENTSGGAA AALNSLRGSS
210 220 230 240 250
YSNYDDAAAD YEPIRTTENI YESIGGSRTS GPENTSGGAA AALNSLRGSS
260 270 280 290 300
YSNYDDAAAD YEPIRTTENI YESIGGSRTS GPENTSDGAA AAALNSLRGS
310 320 330 340 350
SYTTGPRNEG VFGPGPEGLP DMSLPSYDPT NKTSLLTFLS NPHVKSKMLE
360 370 380 390 400
NSGHFVFIDT DRSSFILVPN GNWDQVCSIK VQNGKTKEDL DIKDLENMCA
410 420 430 440 450
KFCTGFSKFS GDWDSLVEPM VSAKAGVASG GNLPNTVIIN NKFKTCVAYG
460 470 480 490 500
PWNSQEASSG YTPSAWRRGH RVDFGGIFEK ANDFNKINWG TQAGPSSEDD
510 520 530 540 550
GISFSNETPG AGPAAAPSPT PSSIPIINVN VNVGGTNVNI GDTNVNTTNT
560 570 580 590 600
TPTTQSTDAS TDTSDIDDIN TNNQTDDINT TDKDSDGAGG VNGDISETES
610 620 630 640 650
SSGDDSGSVS SSESDKNASV GNDGPAMKDI LSAVRKHLDV VYPGENGGST
660 670 680 690 700
EGPLPANQTL GDVISDVENK GSAQDTKLSG NTGAGDDDPT TTAAVGNGAE
710 720 730 740 750
EITLSDTDSG IGDDVSDTAS SSGDESGGVS SPSSESNKNT AVGNDGPSGL
760 770 780 790 800
DILAAVRKHL DKVYPGDNGG STEGPLQANQ TLGDIVQDME TTGTSQETVV
810 820 830 840 850
SPWKGSTSST ESAGGSGSVQ TLLPSPPPTP STTTLRTGTG ATTTSLMMGG
860 870 880 890 900
PIKADIITTG GGGRIPGGGT LEKLLPRIRA HLDISFDAQG DLVSTEEPQL
910 920 930 940 950
GSIVNKFRQE TGSRGILAFV ESAPGKPGSA QVLTGTGGDK GNLFQAAAAV
960 970 980 990 1000
TQALGNVAGK VNLAIQGQKL SSLVNDDGKG SVGRDLFQAA AQTTQVLSAL

IDTVG
Length:1,005
Mass (Da):102,132
Last modified:November 1, 1998 - v1
Checksum:iEC47EC389851CD1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68056.1.
PIRiC71513.
RefSeqiNP_219969.1. NC_000117.1.
WP_010725202.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68056; AAC68056; CT_456.
GeneIDi884231.
KEGGictr:CT_456.
PATRICi20380481. VBIChlTra43535_0493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68056.1.
PIRiC71513.
RefSeqiNP_219969.1. NC_000117.1.
WP_010725202.1. NC_000117.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68056; AAC68056; CT_456.
GeneIDi884231.
KEGGictr:CT_456.
PATRICi20380481. VBIChlTra43535_0493.

Phylogenomic databases

OMAiDVIRDME.

Family and domain databases

InterProiView protein in InterPro
IPR011443. DUF1547.
PfamiView protein in Pfam
PF07577. DUF1547. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTARP_CHLTR
AccessioniPrimary (citable) accession number: O84462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.