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Reviewed, UniProtKB/Swiss-Prot O84457 (CDSA_CHLTR)

Last modified June 16, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase
Gene names
Name: cdsA
Ordered Locus Names: CT_451
OrganismChlamydia trachomatis [Complete proteome] [HAMAP]
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDS family.

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Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Phosphatidate cytidylyltransferase
PRO_0000090733

Regions

Transmembrane27 – 4721 Potential
Transmembrane67 – 8721 Potential
Transmembrane96 – 11621 Potential
Transmembrane124 – 14421 Potential
Transmembrane150 – 17021 Potential
Transmembrane202 – 22221 Potential
Transmembrane232 – 25221 Potential
Transmembrane277 – 29721 Potential

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Sequences

Sequence LengthMass (Da)Tools
O84457-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: BAC435DC5677FFCC

FASTA30533,805
        10         20         30         40         50         60 
MFDSDHNSIF QSDLCQRLVV HSILLTFLVI LLCTSLYPSS AFIVGLLSSA CAALGTYEMG 

        70         80         90        100        110        120 
AMVRIKFPFS FTRYSALGSA IFIALTCLTA RCKMCFPEHI DLLPWFFLFF WTIRLVFKSR 

       130        140        150        160        170        180 
HYKLGPIGST GLALFCMLYV SVPIRLFLHI LYGFVHTDTP FVGIWWAIFL IATTKSSDIF 

       190        200        210        220        230        240 
GYFFGKAFGK KRIAPVISPN KTVVGFIAGC CGSILVSLLF YSHLPKAFAD QIAVPWILIA 

       250        260        270        280        290        300 
LGTVLGVSGF FGDIIESTFK RDAQIKNSSD LESIGGMLDV LDSLLLSTPI VYAILLITQN 


RTFLG

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References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

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Cross-references

Sequence databases

AE001273 Genomic DNA. Translation: AAC68051.1.
PIRF71512.
RefSeqNP_219964.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID884225.
GenomeReviewsGene locus CT_451 in contig AE001273_GR.
KEGGctr:CT451.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO84457.
OMAO84457. LYVSVPI.

Enzyme and pathway databases

BioCycCTRA315277:CT451-MON.
BRENDA2.7.7.41. 108.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCDSA_CHLTR
AccessionPrimary (citable) accession number: O84457
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents