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Protein

Elongation factor G

Gene

fusA

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi82 – 86GTPBy similarity5
Nucleotide bindingi136 – 139GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G
Short name:
EF-G
Gene namesi
Name:fusA
Ordered Locus Names:CT_437
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000911051 – 694Elongation factor GAdd BLAST694

Interactioni

Protein-protein interaction databases

STRINGi272561.CT437.

Structurei

3D structure databases

ProteinModelPortaliO84444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 288tr-type GAdd BLAST280

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
InParanoidiO84444.
KOiK02355.
OMAiKLGVAIQ.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQEFGLDA IRNIGIMAHI DAGKTTTTER ILFYAGRTHK IGEVHEGGAT
60 70 80 90 100
MDWMEQEQER GITITSAATT VFWLGAKINI IDTPGHVDFT IEVERSLRVL
110 120 130 140 150
DGAVAVFDAV SGVEPQSETV WRQANKYGVP RIAFVNKMDR MGANYFGAIE
160 170 180 190 200
SMREKLGANA IPVHCPIGSE SQFVGMVDLI SQKTLYFLEE TLGAKWEERE
210 220 230 240 250
IPEDLQEQCA TLRMQLLEEL ATVDESNEAF MEKVLENPDS ITEEEIHTVM
260 270 280 290 300
RKGVIEGKIN PVLCGSAFKN KGVQQLLDVI VKWLPSPLDR GNVRGINLKT
310 320 330 340 350
GEEVSLKPSK DGPLAALAFK IMTDPYVGRI TFIRIYSGTL KKGSAILNST
360 370 380 390 400
KDKKERISRL LEMHANERTD RDEFTVGDIG ACVGLKFSVT GDTLCDENQE
410 420 430 440 450
IVLERIEAPE PVIDMAIEPK SKGDREKLAQ ALSALSEEDP TFRVSTNEET
460 470 480 490 500
GQTIISGMGE LHLDILRDRM IREFRVEANV GKPQVSYKET ITKTSNSETK
510 520 530 540 550
YVKQSGGRGQ YAHVCLEIEP NEPGKGNEVV SKIVGGVIPK EYIPAVIKGV
560 570 580 590 600
EEGLNSGVLA GYGLVDVKVS IVFGSYHEVD SSEMAFKICG SMAVKEACRK
610 620 630 640 650
ALPVILEPIM KVTVITPEDH LGDVIGDLNR RRGKILGQES SRNMAQVSAE
660 670 680 690
VPLSEMFGYM TSLRSLTSGR ATSTMEPAFF AKVPQKIQEE IVKK
Length:694
Mass (Da):76,538
Last modified:November 1, 1998 - v1
Checksum:i58BDA7CA96D0A8E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68036.1.
PIRiF71514.
RefSeqiNP_219949.1. NC_000117.1.
WP_009871792.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68036; AAC68036; CT_437.
GeneIDi884230.
KEGGictr:CT_437.
PATRICi20380439. VBIChlTra43535_0472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68036.1.
PIRiF71514.
RefSeqiNP_219949.1. NC_000117.1.
WP_009871792.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68036; AAC68036; CT_437.
GeneIDi884230.
KEGGictr:CT_437.
PATRICi20380439. VBIChlTra43535_0472.

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
InParanoidiO84444.
KOiK02355.
OMAiKLGVAIQ.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFG_CHLTR
AccessioniPrimary (citable) accession number: O84444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.