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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CT_411
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Lipid-A-disaccharide synthasePRO_0000190161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT411.

Structurei

3D structure databases

ProteinModelPortaliO84416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 607383Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
InParanoidiO84416.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

O84416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT
60 70 80 90 100
GAVFMICHGF IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV
110 120 130 140 150
SVATAITVSF AIGTRYLPHM TWMASPNILH LNLPEASLSW QLIGCIGLTI
160 170 180 190 200
FSLRFFIQWF YLEYKNQSAL PAPFWKASLL GGSICLLYFL RTGDLVNVLC
210 220 230 240 250
YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL GGNLLKEMHA
260 270 280 290 300
KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL
310 320 330 340 350
LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR
360 370 380 390 400
PSRKTVLEKY LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL
410 420 430 440 450
NWKDQLHLPT DKPFIAAFPG SRRSDILRNL TIQVQAFQAS SLASTHHLLV
460 470 480 490 500
SSANPEYDHL ILEVLQQNRC LHSHIVPSQF RYELMRECDF ALAKCGTIVL
510 520 530 540 550
ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI
560 570 580 590 600
GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS

LIFETAS
Length:607
Mass (Da):69,030
Last modified:November 1, 1998 - v1
Checksum:i8DF4430905BD6991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68008.1.
PIRiE71518.
RefSeqiNP_219921.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68008; AAC68008; CT_411.
GeneIDi884705.
KEGGictr:CT_411.
PATRICi20380375. VBIChlTra43535_0442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68008.1.
PIRiE71518.
RefSeqiNP_219921.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT411.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68008; AAC68008; CT_411.
GeneIDi884705.
KEGGictr:CT_411.
PATRICi20380375. VBIChlTra43535_0442.

Phylogenomic databases

eggNOGiCOG3952.
InParanoidiO84416.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiLPXB_CHLTR
AccessioniPrimary (citable) accession number: O84416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.