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O84416 (LPXB_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:CT_411
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

In the C-terminal section; belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 607607Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190161

Regions

Region1 – 224224Unknown HAMAP-Rule MF_00392
Region225 – 607383Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

Sequence LengthMass (Da)Tools
O84416 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8DF4430905BD6991

FASTA60769,030
        10         20         30         40         50         60 
MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT GAVFMICHGF 

        70         80         90        100        110        120 
IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV SVATAITVSF AIGTRYLPHM 

       130        140        150        160        170        180 
TWMASPNILH LNLPEASLSW QLIGCIGLTI FSLRFFIQWF YLEYKNQSAL PAPFWKASLL 

       190        200        210        220        230        240 
GGSICLLYFL RTGDLVNVLC YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL 

       250        260        270        280        290        300 
GGNLLKEMHA KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL 

       310        320        330        340        350        360 
LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR PSRKTVLEKY 

       370        380        390        400        410        420 
LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL NWKDQLHLPT DKPFIAAFPG 

       430        440        450        460        470        480 
SRRSDILRNL TIQVQAFQAS SLASTHHLLV SSANPEYDHL ILEVLQQNRC LHSHIVPSQF 

       490        500        510        520        530        540 
RYELMRECDF ALAKCGTIVL ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII 

       550        560        570        580        590        600 
LGRTIFPEFI GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS 


LIFETAS 

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC68008.1.
PIRE71518.
RefSeqNP_219921.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT411.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC68008; AAC68008; CT_411.
GeneID884705.
KEGGctr:CT_411.
PATRIC20380375. VBIChlTra43535_0442.

Phylogenomic databases

eggNOGCOG3952.
KOK00748.
OMAKIIHYVC.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_CHLTR
AccessionPrimary (citable) accession number: O84416
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways