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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.By similarity

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.

Pathwayi: lipoprotein biosynthesis (signal peptide cleavage)

This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116By similarity1
Active sitei143By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-431-MONOMER
UniPathwayiUPA00665

Protein family/group databases

MEROPSiA08.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidase (EC:3.4.23.36)
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name:
SPase II
Gene namesi
Name:lspA
Ordered Locus Names:CT_408
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787771 – 167Lipoprotein signal peptidaseAdd BLAST167

Structurei

3D structure databases

SMRiO84413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41082ST Bacteria
COG0597 LUCA
InParanoidiO84413
KOiK03101
OMAiGFDFAIF

Family and domain databases

HAMAPiMF_00161 LspA, 1 hit
InterProiView protein in InterPro
IPR001872 Peptidase_A8
PANTHERiPTHR33695 PTHR33695, 1 hit
PfamiView protein in Pfam
PF01252 Peptidase_A8, 1 hit
PRINTSiPR00781 LIPOSIGPTASE
TIGRFAMsiTIGR00077 lspA, 1 hit
PROSITEiView protein in PROSITE
PS00855 SPASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O84413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTRSLPTFL TLLLLASIDW VSKLVVLLKS CQLSPHSSAF LYSYVWGHFS
60 70 80 90 100
FLIIPSFNEG AAFGLFTQYK IPLLIFRVCV ILGLALFLRI KYKSLHRRTR
110 120 130 140 150
VALTLILAGA LGNVGDILLY GKVVDFLSLS YYSWRFPSFN LADAFISIGT
160
LLLIGHLYFT KESKKYF
Length:167
Mass (Da):18,940
Last modified:November 1, 1998 - v1
Checksum:i0B9752F830B01F12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68005.1
PIRiB71518
RefSeqiNP_219918.1, NC_000117.1
WP_009871760.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68005; AAC68005; CT_408
GeneIDi35556630
884706
KEGGictr:CT_408
PATRICifig|272561.5.peg.439

Similar proteinsi

Entry informationi

Entry nameiLSPA_CHLTR
AccessioniPrimary (citable) accession number: O84413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health