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O84410

- RISA_CHLTR

UniProt

O84410 - RISA_CHLTR

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Protein

Riboflavin synthase

Gene
ribE, ribC, CT_405
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
  2. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:CT_405
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Riboflavin synthasePRO_0000068165Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi272561.CT405.

Structurei

3D structure databases

ProteinModelPortaliO84410.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 9595Lumazine-binding 1Add
BLAST
Repeati96 – 18893Lumazine-binding 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 63Substrate binding By similarity
Regioni46 – 483Substrate binding By similarity
Regioni60 – 656Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0307.
KOiK00793.
OMAiNIEFDPQ.
OrthoDBiEOG6VMTQH.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84410-1 [UniParc]FASTAAdd to Basket

« Hide

MFSGIIQEVA RVDLIHHLRD SMEIGVFARK LIDVVPGSSF SVDGICLTLV    50
KRQYELLFFD VTEETMAWTT IKDYTVGTMV NLERSVRLGD EIGGHFVSGH 100
VCGIGTIIAI EKSYMFFKAP ANLVPYILEK GFIAIDGISL TIARVKGDIF 150
SVSLIPETRA RTSLGYKQVG AHVNMEPDMM TKMQVDTIMR FHAEKEISK 199
Length:199
Mass (Da):22,222
Last modified:November 1, 1998 - v1
Checksum:iC815DE0AC8534E16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68002.1.
PIRiH71519.
RefSeqiNP_219915.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68002; AAC68002; CT_405.
GeneIDi884709.
KEGGictr:CT_405.
PATRICi20380363. VBIChlTra43535_0436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC68002.1 .
PIRi H71519.
RefSeqi NP_219915.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC68002 ; AAC68002 ; CT_405 .
GeneIDi 884709.
KEGGi ctr:CT_405.
PATRICi 20380363. VBIChlTra43535_0436.

Phylogenomic databases

eggNOGi COG0307.
KOi K00793.
OMAi NIEFDPQ.
OrthoDBi EOG6VMTQH.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00405 .

Family and domain databases

Gene3Di 2.40.30.20. 2 hits.
InterProi IPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
PANTHERi PTHR21098. PTHR21098. 1 hit.
Pfami PF00677. Lum_binding. 2 hits.
[Graphical view ]
PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMi SSF63380. SSF63380. 2 hits.
TIGRFAMsi TIGR00187. ribE. 1 hit.
PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiRISA_CHLTR
AccessioniPrimary (citable) accession number: O84410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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