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Protein

Riboflavin synthase

Gene

ribE

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130Lumazine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-428-MONOMER
UniPathwayiUPA00275; UER00405

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:CT_405
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681651 – 199Riboflavin synthaseAdd BLAST199

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO84410
SMRiO84410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 95Lumazine-binding 1Add BLAST95
Repeati96 – 188Lumazine-binding 2Add BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Lumazine 1 bindingBy similarity3
Regioni46 – 48Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni60 – 65Lumazine 2 binding; shared with one trimeric partnerBy similarity6
Regioni99 – 101Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni139 – 141Lumazine 1 bindingBy similarity3
Regioni153 – 158Lumazine 1 bindingBy similarity6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108R6K Bacteria
COG0307 LUCA
InParanoidiO84410
KOiK00793
OMAiHFVTGHV

Family and domain databases

CDDicd00402 Riboflavin_synthase_like, 1 hit
Gene3Di2.40.30.20, 2 hits
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR001783 Lumazine-bd
IPR026017 Lumazine-bd_dom
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR21098 PTHR21098, 1 hit
PfamiView protein in Pfam
PF00677 Lum_binding, 2 hits
PIRSFiPIRSF000498 Riboflavin_syn_A, 1 hit
SUPFAMiSSF63380 SSF63380, 2 hits
TIGRFAMsiTIGR00187 ribE, 1 hit
PROSITEiView protein in PROSITE
PS51177 LUMAZINE_BIND, 2 hits

Sequencei

Sequence statusi: Complete.

O84410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGIIQEVA RVDLIHHLRD SMEIGVFARK LIDVVPGSSF SVDGICLTLV
60 70 80 90 100
KRQYELLFFD VTEETMAWTT IKDYTVGTMV NLERSVRLGD EIGGHFVSGH
110 120 130 140 150
VCGIGTIIAI EKSYMFFKAP ANLVPYILEK GFIAIDGISL TIARVKGDIF
160 170 180 190
SVSLIPETRA RTSLGYKQVG AHVNMEPDMM TKMQVDTIMR FHAEKEISK
Length:199
Mass (Da):22,222
Last modified:November 1, 1998 - v1
Checksum:iC815DE0AC8534E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68002.1
PIRiH71519
RefSeqiNP_219915.1, NC_000117.1
WP_010725187.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68002; AAC68002; CT_405
GeneIDi35550440
884709
KEGGictr:CT_405
PATRICifig|272561.5.peg.436

Similar proteinsi

Entry informationi

Entry nameiRISA_CHLTR
AccessioniPrimary (citable) accession number: O84410
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health