O84410 (RISA_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin synthase
Short name=RS
EC=2.5.1.9

Gene names

Name:	ribE
Synonyms:	ribC
Ordered Locus Names:	CT_405

Organism

Chlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]

Taxonomic identifier

272561 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › Chlamydia trachomatis

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.
Subunit structure	Homotrimer By similarity.
Sequence similarities	Contains 2 lumazine-binding repeats.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Domain	Repeat
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro riboflavin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Riboflavin synthase		PRO_0000068165
Regions
	Repeat	1 – 95	95	Lumazine-binding 1
	Repeat	96 – 188	93	Lumazine-binding 2
	Region	4 – 6	3	Substrate binding By similarity
	Region	46 – 48	3	Substrate binding By similarity
	Region	60 – 65	6	Substrate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	O84410 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: C815DE0AC8534E16	FASTA	199	22,222
	10 20 30 40 50 60 MFSGIIQEVA RVDLIHHLRD SMEIGVFARK LIDVVPGSSF SVDGICLTLV KRQYELLFFD 70 80 90 100 110 120 VTEETMAWTT IKDYTVGTMV NLERSVRLGD EIGGHFVSGH VCGIGTIIAI EKSYMFFKAP 130 140 150 160 170 180 ANLVPYILEK GFIAIDGISL TIARVKGDIF SVSLIPETRA RTSLGYKQVG AHVNMEPDMM 190 TKMQVDTIMR FHAEKEISK

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC68002.1.
PIR	H71519.
RefSeq	NP_219915.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84410.
ModBase	Search...
Protein-protein interaction databases
STRING	272561.CT405.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC68002; AAC68002; CT_405.
GeneID	884709.
KEGG	ctr:CT405.
PATRIC	20380363. VBIChlTra43535_0436.
Phylogenomic databases
eggNOG	COG0307.
KO	K00793.
OMA	HILSGHV.
ProtClustDB	PRK13020.
Enzyme and pathway databases
UniPathway	UPA00275; UER00405.
Family and domain databases
Gene3D	2.40.30.20. 2 hits.
InterPro	IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR001783. Lumazine-bd. IPR026017. Lumazine-bd_dom. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
PANTHER	PTHR21098. PTHR21098. 1 hit.
Pfam	PF00677. Lum_binding. 2 hits. [Graphical view]
PIRSF	PIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAM	SSF63380. Riboflavin_synthase_like_b-brl. 2 hits.
TIGRFAMs	TIGR00187. ribE. 1 hit.
PROSITE	PS51177. LUMAZINE_BIND. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RISA_CHLTR

Accession

Primary (citable) accession number: O84410

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program