O84410 (RISA_CHLTR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 68.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Riboflavin synthase alpha chain EC=2.5.1.9 | ||||||
| Gene names |
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| Organism | Chlamydia trachomatis | ||||||
| Taxonomic identifier | 813 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione By similarity. |
| Catalytic activity | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
| Pathway | |
| Subunit structure | Oligomer that consist of 3 alpha subunits and 60 beta subunits By similarity. |
| Sequence similarities | Contains 2 lumazine-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Riboflavin biosynthesis |
| Domain | Repeat |
| Molecular function | Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | oxidoreductase activity Inferred from electronic annotation. Source: InterPro riboflavin synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001273 Genomic DNA. Translation: AAC68002.1. |
| PIR | H71519. |
| RefSeq | NP_219915.1. NC_000117.1. |
3D structure databases | |
| ProteinModelPortal | O84410. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 884709. |
| GenomeReviews | Gene locus CT_405 in contig AE001273_GR. |
| KEGG | ctr:CT405. |
| PATRIC | 20380363. VBIChlTra43535_0436. |
Phylogenomic databases | |
| HOGENOM | HBG289809. |
| OMA | HILSGHV. |
| ProtClustDB | PRK13020. |
Family and domain databases | |
| InterPro | IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR001783. Lumazine-bd. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view] |
| Gene3D | G3DSA:2.40.30.20. G3DSA:2.40.30.20. 2 hits. |
| KO | K00793. |
| PANTHER | PTHR21098. Lumazine_bd. 1 hit. |
| Pfam | PF00677. Lum_binding. 2 hits. [Graphical view] |
| PIRSF | PIRSF000498. Riboflavin_syn_A. 1 hit. |
| SUPFAM | SSF63380. Riboflavin_synthase_like_b-brl. 2 hits. |
| TIGRFAMs | TIGR00187. RibE. 1 hit. |
| PROSITE | PS51177. LUMAZINE_BIND. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RISA_CHLTR | ||||||||
| Accession | Primary (citable) accession number: O84410 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with