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O84374 (AROB_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CT_369
OrganismChlamydia trachomatis
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3733733-dehydroquinate synthase HAMAP MF_00110
PRO_0000140728

Sequences

Sequence LengthMass (Da)Tools
O84374 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 30A300C4C37E7EAA

FASTA37341,153
        10         20         30         40         50         60 
MIELVTDSPH PIHLVDSLQN PKLFASLSTD FPLIFITNTK LNALILPPLL DLARSLGFSV 

        70         80         90        100        110        120 
ETLTIPEGEE TKTGDTFLSL HQQLTDLNVP RQATLIGVGG GVILDIAGFV AATHCRGMPF 

       130        140        150        160        170        180 
IAIPTTLVAM IDASIGGKNG INLNHIKNRI GSFYLPKAVW ICPRKLSFLP QQELHHGIAE 

       190        200        210        220        230        240 
CIKHAYIADS AILPLLQDPN ALKKEDKLSL LIKKNCLCKA SVVQQDVRDY AKRQILNFGH 

       250        260        270        280        290        300 
TLGHALEMLF IGKIPHSCAI SVGMVLETKL SLSLGVARSP AILHSLIQDL LRYQLPVSLK 

       310        320        330        340        350        360 
DLYMRAQIPP HNCDQILSAL TYDKKKQNTP LPPFVMIEEI GLAASFDGRF CQTISKHILT 

       370 
KVLEEEFYAM HNN

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001273 Genomic DNA. Translation: AAC67965.1.
PIRB71523.
RefSeqNP_219878.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84374.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID884750.
GenomeReviewsGene locus CT_369 in contig AE001273_GR.
KEGGctr:CT369.
PATRIC20380287. VBIChlTra43535_0398.

Phylogenomic databases

HOGENOMHBG632303.
OMALGQSDFT.
PhylomeDBO84374.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CHLTR
AccessionPrimary (citable) accession number: O84374
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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