O84373 (AROC_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	CT_368

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Chorismate synthase HAMAP MF_00300		PRO_0000140575

Sequences

	Sequence		Length	Mass (Da)
	O84373 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 439F0EF656FC4FF2	FASTA	357	38,021
	10 20 30 40 50 60 MHNQYGSIFS ITTWGESHGP AIGVVIDGCP AGLSLSPEDF LPAMARRRPG QLHTSPRQEP 70 80 90 100 110 120 DLVTILSGVY QNKTTGTPIS LLIENKDVSS SSYEQLQHCY RPGHAQFAYE GKYGFADNRG 130 140 150 160 170 180 GGRASARETA SRVAAGVIAK KILLSQRIET LAFLSGFGTL ESKNYPKLSD SLIQQVHTSP 190 200 210 220 230 240 FYTLLPQEEI QNLLLLNPDD SFGGVVSFIT SPLPIGLGEP VFGKLPALLA AAMMSIPAAK 250 260 270 280 290 300 GFEIGAGFSS SQMTGSAYLD AFIADESGVS LQSNRCGGAL GGISIGQPLE GRVAFKPTSS 310 320 330 340 350 IKKPCSSVLK DGTLIAYRTP NQGRHDPCVA IRAVAVVEAM LDLTLVDLLL QHRCTQL

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67964.1.
PIR	A71523.
RefSeq	NP_219877.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84373.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884745.
GenomeReviews	Gene locus CT_368 in contig AE001273_GR.
KEGG	ctr:CT368.
PATRIC	20380285. VBIChlTra43535_0397.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_CHLTR

Accession

Primary (citable) accession number: O84373

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program