ID   AK_CHLTR                Reviewed;         431 AA.
AC   O84367;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=CT_362;
OS   Chlamydia trachomatis.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
OX   NCBI_TaxID=813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   MEDLINE=99000809; PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA   Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans:
RT   Chlamydia trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
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DR   EMBL; AE001273; AAC67958.1; -; Genomic_DNA.
DR   PIR; G71524; G71524.
DR   RefSeq; NP_219871.1; -.
DR   GeneID; 884754; -.
DR   GenomeReviews; AE001273_GR; CT_362.
DR   KEGG; ctr:CT362; -.
DR   HOGENOM; O84367; -.
DR   OMA; O84367; RERHESI.
DR   BioCyc; CTRA315277:CT362-MON; -.
DR   BRENDA; 2.7.2.4; 108.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001341; Asp_kin_reg.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   Gene3D; G3DSA:3.40.1160.10; Aa_kinase; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    431       Aspartokinase.
FT                                /FTId=PRO_0000066675.
SQ   SEQUENCE   431 AA;  47648 MW;  170F9B7DB1DCC919 CRC64;
     MLRQETAPLV CKFGGTSVGT AQSIRRVCEI IQEERPSFVV VSAVAGVTDW LEEFCRLPKG
     KRAALTEKIR ERHESIAKEL GIEVSLAIFW EILEHFEDVE ELFSEDQARI LAIGEDLSST
     LICSYCCTYV LPLKRLEARQ VILTDSQFLR AVPDLALMQT AWGELALQED TIYLMQGFLG
     ATSSGKTTVL GRGGSDFSAS LIGELCKARE LRIYTDVCGV HTADPKILKD TQLIDSLTFE
     EMQELASSGA KVLHQDMLKP CVRAKVPIFV TSTFNVTKEG TWICASLNES TEGPVIKALS
     LKSNQALWFV EYNSPLVRLE DVLGCVRSLG FVPGVVMAQS LGVYFTIDWE EYPQTITKAL
     EAFGTVSCEG PLSLVALVGA KLASWSMSRV FEALHRTPVL CWSQTDTVIN LIINKDFGVA
     VTELLHDCLF K
//