Reviewed, UniProtKB/Swiss-Prot O84367 (AK_CHLTR)

Names and originHide

Protein names

Recommended name:
Aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	CT_362

Organism

Chlamydia trachomatis [Complete proteome] [HAMAP]

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributesHide

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

OntologiesHide

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Aspartokinase		PRO_0000066675

SequencesHide

	Sequence		Length	Mass (Da)
	O84367-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 170F9B7DB1DCC919	FASTA	431	47,648
	10 20 30 40 50 60 MLRQETAPLV CKFGGTSVGT AQSIRRVCEI IQEERPSFVV VSAVAGVTDW LEEFCRLPKG 70 80 90 100 110 120 KRAALTEKIR ERHESIAKEL GIEVSLAIFW EILEHFEDVE ELFSEDQARI LAIGEDLSST 130 140 150 160 170 180 LICSYCCTYV LPLKRLEARQ VILTDSQFLR AVPDLALMQT AWGELALQED TIYLMQGFLG 190 200 210 220 230 240 ATSSGKTTVL GRGGSDFSAS LIGELCKARE LRIYTDVCGV HTADPKILKD TQLIDSLTFE 250 260 270 280 290 300 EMQELASSGA KVLHQDMLKP CVRAKVPIFV TSTFNVTKEG TWICASLNES TEGPVIKALS 310 320 330 340 350 360 LKSNQALWFV EYNSPLVRLE DVLGCVRSLG FVPGVVMAQS LGVYFTIDWE EYPQTITKAL 370 380 390 400 410 420 EAFGTVSCEG PLSLVALVGA KLASWSMSRV FEALHRTPVL CWSQTDTVIN LIINKDFGVA 430 VTELLHDCLF K

ReferencesHide

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67958.1.
PIR	G71524.
RefSeq	NP_219871.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	884754.
GenomeReviews	Gene locus CT_362 in contig AE001273_GR.
KEGG	ctr:CT362.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG724395.
OMA	GTWICAS.
ProtClustDB	PRK05925.
Enzyme and pathway databases
BioCyc	CTRA315277-1:CT362-MONOMER.
BRENDA	2.7.2.4. 108.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

AK_CHLTR

Accession

Primary (citable) accession number: O84367

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	July 13, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)