O84348 (LON_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lon protease
EC=3.4.21.53

Alternative name(s):
ATP-dependent protease La

Gene names

Name:	lon
Ordered Locus Names:	CT_344

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	819 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subunit structure	Homohexamer. Organized in a ring with a central cavity By similarity.
Subcellular location	Cytoplasm By similarity.
Induction	By heat shock By similarity.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 819	819	Lon protease		PRO_0000076132
Regions
	Domain	41 – 237	197	Lon
	Nucleotide binding	392 – 399	8	ATP By similarity
Sites
	Active site	724	1	By similarity
	Active site	767	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O84348 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: FEA7802A5441557C	FASTA	819	91,965
	10 20 30 40 50 60 MNSTNNTDSQ NLDPNASEVE KLLDESAEAE EKVDDHTPPS ELFILPLNKR PFFPGMAAPL 70 80 90 100 110 120 LIEAGPHYEV LTLLAKSSQK HIGLVLTKKE DANTLKVGFN QLHRVGVSAR ILRIMPIEGG 130 140 150 160 170 180 SAQVLLSIED RIRIVKPIQD KYLKAKVSYH KENKELTEEL KAYSISIVSI IKDLLKLNPL 190 200 210 220 230 240 FKEELQIFLG HSDFTEPGKL ADFSVALTTA TREELQEILE TTDMHDRIDK ALVLLKKELD 250 260 270 280 290 300 LSRLQSSINQ KIEATITKSQ KEFFLKEQLK TIKKELGLEK DDHAVDLEKF MERFNKRDVP 310 320 330 340 350 360 QYAMDVIQDE MDKLQTLETS SAEYAVCRNY LDWLTIVPWG IQTKEYHDLK KAESILNKDH 370 380 390 400 410 420 YGLEDIKQRI LELISVGKLA NGMKGSIICL VGPPGVGKTS IGRSIAKVLH RKFFRFSVGG 430 440 450 460 470 480 MRDEAEIKGH RRTYIGAMPG KLVQALKQSQ IMNPVIMIDE VDKIGSSYHG DPASALLEVL 490 500 510 520 530 540 DPEQNKDFLD HYLDVRVDLS NVLFILTANV LDSIPDPLLD RMEVLRLSGY ILEEKLQIAT 550 560 570 580 590 600 KYLVPRARKE MGLSAQNVTF QPEALKHMIN NYAREAGVRT LNENIKKVLR KVALKIVQNQ 610 620 630 640 650 660 EKNLSKKSRF TITPKNLQDY LGKPVFSSDR FYEKTPVGVA TGLAWTSLGG ATLYIESVQV 670 680 690 700 710 720 PSSSGKADMH LTGQAGDVMK ESSQIAWTYL HSALERYAPG QPFFEKSQVH IHIPEGATPK 730 740 750 760 770 780 DGPSAGITMV TSLLSLLLDV PVLNNLGMTG ELTLTGRVLG IGGIREKLIA ARRSKLNILI 790 800 810 FPEDNRRDYD ELPAYLKKGL KVHFVTHYDD VFKIAFPGV

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67939.1.
PIR	C71527.
RefSeq	NP_219851.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84348.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884768.
GenomeReviews	Gene locus CT_344 in contig AE001273_GR.
KEGG	ctr:CT344.
PATRIC	20380233. VBIChlTra43535_0372.
Phylogenomic databases
HOGENOM	HBG566281.
OMA	LPEPNRG.
ProtClustDB	CLSK2459232.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR015947. PUA-like_domain. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
KO	K01338.
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PIRSF	PIRSF001174. Lon_proteas. 1 hit.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
SUPFAM	SSF88697. PUA-like. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00763. Lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON_CHLTR

Accession

Primary (citable) accession number: O84348

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program