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Protein

Lon protease

Gene

lon

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei724 – 7241UniRule annotation
Active sitei767 – 7671UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi392 – 3998ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:CT_344
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Lon proteasePRO_0000076132Add
BLAST

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi272561.CT344.

Structurei

3D structure databases

ProteinModelPortaliO84348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 237196Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini634 – 818185Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
InParanoidiO84348.
KOiK01338.
OMAiDRMDILR.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTNNTDSQ NLDPNASEVE KLLDESAEAE EKVDDHTPPS ELFILPLNKR
60 70 80 90 100
PFFPGMAAPL LIEAGPHYEV LTLLAKSSQK HIGLVLTKKE DANTLKVGFN
110 120 130 140 150
QLHRVGVSAR ILRIMPIEGG SAQVLLSIED RIRIVKPIQD KYLKAKVSYH
160 170 180 190 200
KENKELTEEL KAYSISIVSI IKDLLKLNPL FKEELQIFLG HSDFTEPGKL
210 220 230 240 250
ADFSVALTTA TREELQEILE TTDMHDRIDK ALVLLKKELD LSRLQSSINQ
260 270 280 290 300
KIEATITKSQ KEFFLKEQLK TIKKELGLEK DDHAVDLEKF MERFNKRDVP
310 320 330 340 350
QYAMDVIQDE MDKLQTLETS SAEYAVCRNY LDWLTIVPWG IQTKEYHDLK
360 370 380 390 400
KAESILNKDH YGLEDIKQRI LELISVGKLA NGMKGSIICL VGPPGVGKTS
410 420 430 440 450
IGRSIAKVLH RKFFRFSVGG MRDEAEIKGH RRTYIGAMPG KLVQALKQSQ
460 470 480 490 500
IMNPVIMIDE VDKIGSSYHG DPASALLEVL DPEQNKDFLD HYLDVRVDLS
510 520 530 540 550
NVLFILTANV LDSIPDPLLD RMEVLRLSGY ILEEKLQIAT KYLVPRARKE
560 570 580 590 600
MGLSAQNVTF QPEALKHMIN NYAREAGVRT LNENIKKVLR KVALKIVQNQ
610 620 630 640 650
EKNLSKKSRF TITPKNLQDY LGKPVFSSDR FYEKTPVGVA TGLAWTSLGG
660 670 680 690 700
ATLYIESVQV PSSSGKADMH LTGQAGDVMK ESSQIAWTYL HSALERYAPG
710 720 730 740 750
QPFFEKSQVH IHIPEGATPK DGPSAGITMV TSLLSLLLDV PVLNNLGMTG
760 770 780 790 800
ELTLTGRVLG IGGIREKLIA ARRSKLNILI FPEDNRRDYD ELPAYLKKGL
810
KVHFVTHYDD VFKIAFPGV
Length:819
Mass (Da):91,965
Last modified:November 1, 1998 - v1
Checksum:iFEA7802A5441557C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67939.1.
PIRiC71527.
RefSeqiNP_219851.1. NC_000117.1.
WP_009871695.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67939; AAC67939; CT_344.
GeneIDi884768.
KEGGictr:CT_344.
PATRICi20380233. VBIChlTra43535_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67939.1.
PIRiC71527.
RefSeqiNP_219851.1. NC_000117.1.
WP_009871695.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67939; AAC67939; CT_344.
GeneIDi884768.
KEGGictr:CT_344.
PATRICi20380233. VBIChlTra43535_0372.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
InParanoidiO84348.
KOiK01338.
OMAiDRMDILR.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLON_CHLTR
AccessioniPrimary (citable) accession number: O84348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.