O84335 (DXS_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	CT_331

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189103

Sequences

	Sequence		Length	Mass (Da)
	O84335 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 0D45A1DBA91F66D1	FASTA	640	70,726
	10 20 30 40 50 60 MTYSLLPHIH SPQDLHALSL DKLPVLCDEI RNKIIESLSL TGGHLASNLG GVELTVALHY 70 80 90 100 110 120 VFSSPDDQFI FDVGHQSYVH KLLTGRNTEA FSNIRHDNGL SGFTTPQESN HDIFFSGHAG 130 140 150 160 170 180 NALSLALGLA KGSSNSSSHI LPILGDAAFS CGLTLEALNN IPADLSKFII VLNDNQMSIS 190 200 210 220 230 240 ENVGNIPQGI SHWMYPQKIS KLSQKIHSWI QNLPSFLHKK KTLSHKVDIA LKSLSHPLFE 250 260 270 280 290 300 QFGLHYVGPI DGHNVKKLVQ ALQMIKDQPQ PILFHVCTVK GNGLAEAERD PIRYHGVKAH 310 320 330 340 350 360 FQNTSLKKTS GNVELQTPIS FPQHAGNILC RLGKKYPQLQ VVTPAMSLGS CLEDFRKQFP 370 380 390 400 410 420 DRFTDVGIAE GHAVTFSAGI ARSGTPVCCS IYSTFLHRAM DNVFHDVCMQ ELPVIFAIDR 430 440 450 460 470 480 AGLAFHDGRS HHGIYDLGFL CSMPNMVICQ PRNALVLERL FFSSLLWKSP CAIRYPNIPA 490 500 510 520 530 540 NEKASNSFFP FSPILPGEAE ILCQGDDLLL IALGHMCNTA LTVKEHLLDY GISTTVVDPI 550 560 570 580 590 600 FIKPLDRKLL QSLLTHHSKV IILEEHSIHG GLGSEFLLFL NQHNIKADVL SLGVPDMFIP 610 620 630 640 HGNPETILNL IGLTSDHITQ RILSHFKFST PIPIERFFKA

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67926.1.
PIR	F71527.
RefSeq	NP_219838.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84335.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884788.
GenomeReviews	Gene locus CT_331 in contig AE001273_GR.
KEGG	ctr:CT331.
PATRIC	20380203. VBIChlTra43535_0357.
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CHLTR

Accession

Primary (citable) accession number: O84335

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program