O84316 (RPOC_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta'
Short name=RNAP subunit beta'
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'

Gene names

Name:	rpoC
Ordered Locus Names:	CT_314

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	1396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01322
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01322
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta' chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1396	1396	DNA-directed RNA polymerase subunit beta' HAMAP MF_01322		PRO_0000067730

Sequences

	Sequence		Length	Mass (Da)
	O84316 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: B24BF8841D284065	FASTA	1,396	154,905
	10 20 30 40 50 60 MFREGSRDDA ALVKEGLFDK LEIGIASDVT IRDKWSCGEI KKPETINYRT FKPEKGGLFC 70 80 90 100 110 120 EKIFGPTKDW ECYCGKYKKI KHKGIVCDRC GVEVTLSKVR RERMAHIELA VPIVHIWFFK 130 140 150 160 170 180 TTPSRIGNVL GMTASDLERV IYYEEYVVID PGNTDLVKKQ LLNDAKYREV VEKWGKDAFV 190 200 210 220 230 240 AKMGGEAVYD LLKSEDLESL LGELKERLRK TKSQQARMKL AKRLKIVEGF VSSSNRPEWM 250 260 270 280 290 300 VLKNIPVVPP DLRPLVPLDG GRFATSDLND LYRRVINRNN RLKAILRLKT PEVIVRNEKR 310 320 330 340 350 360 MLQEAVDALF DNGRHGHPVM GAGNRPLKSL SEMLKGKNGR FRQNLLGKRV DYSGRSVIIV 370 380 390 400 410 420 GPELKFNQCG LPKEMALELF EPFIIKRLKD QGSVYTIRSA KKMIQRGAPE VWDVLEEIIK 430 440 450 460 470 480 GHPVLLNRAP TLHRLGIQAF EPVLIEGKAI RVHPLVCAAF NADFDGDQMA VHVPLSIEAQ 490 500 510 520 530 540 LEAKVLMMAP DNIFLPSSGK PVATPSKDMT LGIYYLMADP TYFPEEHGGK TKAFKDEVEV 550 560 570 580 590 600 LRALNAGGFI LKDEICGSRR DETGRGIHIH EKIKVRIDGQ IIETTPGRVF FNTIVPKELG 610 620 630 640 650 660 FQNYSMPSKR ISELILQCYK KVGLEATVRF LDDLKELGFV QSTKAAISMG LKDVKIPEIK 670 680 690 700 710 720 KEILKDAYDK VAVVKKQYED GIITDGERHS KTISIWTEVS DLLSNALYSE IKKQTNSKHN 730 740 750 760 770 780 PLFLMIDSGA RGNKSQLKQL GALRGLMAKP NGAIIESPIT SNFREGLTVL EYSISSHGAR 790 800 810 820 830 840 KGLADTALKT ADSGYLTRRL VDVAQDVIIT ERDCGTLNHI EVSTIRQGSE ELLPLKDRVY 850 860 870 880 890 900 GRTVSENIYQ PGDKSNVLAY AGDVLTSAQA EAIDDAGIES VKIRSTLTCE SRRGVCAKCY 910 920 930 940 950 960 GLNLANGRLI GLGEAVGIIA AQSIGEPGTQ LTMRTFHLGG IAATSSTPEI VAECDGILVY 970 980 990 1000 1010 1020 LDLRVVVDQE GNNLVLNKMG ALHLVQDEGR SLSEYKKLLS TKSIESLATF PVELGAKILV 1030 1040 1050 1060 1070 1080 NDGAAVAAGQ RIAEVELHNI PIICDKPGFV HYEDLVEGVS TEKVTNKNTG LVELIVKQHR 1090 1100 1110 1120 1130 1140 GELHPQIAIY ADANMKELVG TYAIPSGAII SVEEGQRIAP GMLLARLPRG AIKTKDITGG 1150 1160 1170 1180 1190 1200 LPRVAELVEA RKPEDAADIA KIDGVVDFKG IQKNKRILVV RDEITGMEEE HLISLTKHLI 1210 1220 1230 1240 1250 1260 VQRGDSVIKG QQLTDGLVVP HEILEICGVR ELQKYLVNEV QEVYRLQGVD INDKHVEIIV 1270 1280 1290 1300 1310 1320 RQMLQKVRIT DPGDTTLLFG EDVDKKEFYE ENRRTEEDGG KPAQAVPVLL GITKASLGTE 1330 1340 1350 1360 1370 1380 SFISAASFQD TTRVLTDAAC SSKTDYLLGF KENVIMGHMI PGGTGFDTHK RIKQHLEKEQ 1390 EDLVFDFDSE FESVAG

References

[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67907.1.
PIR	G71529.
RefSeq	NP_219819.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84316.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	O84316.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884808.
GenomeReviews	Gene locus CT_314 in contig AE001273_GR.
KEGG	ctr:CT314.
PATRIC	20380155. VBIChlTra43535_0336.
Phylogenomic databases
HOGENOM	HBG621785.
OMA	DINDKHI.
PhylomeDB	O84316.
ProtClustDB	PRK00566.
Family and domain databases
HAMAP	MF_01322. RNApol_bact_RpoC. [Tree]
InterPro	IPR012754. DNA-dir_RpoC_beta_prime. IPR000722. RNA_pol_asu. IPR006592. RNA_pol_N. IPR007080. RNA_pol_Rpb1_1. IPR007066. RNA_pol_Rpb1_3. IPR007083. RNA_pol_Rpb1_4. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
KO	K03046.
Pfam	PF04997. RNA_pol_Rpb1_1. 1 hit. PF00623. RNA_pol_Rpb1_2. 1 hit. PF04983. RNA_pol_Rpb1_3. 1 hit. PF05000. RNA_pol_Rpb1_4. 1 hit. PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
SMART	SM00663. RPOLA_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02386. RpoC_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPOC_CHLTR

Accession

Primary (citable) accession number: O84316

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program