O84310 (VATA_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14

Alternative name(s):
V-ATPase subunit A

Gene names

Name:	atpA
Ordered Locus Names:	CT_308

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. HAMAP MF_00309
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_00309
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 591	591	V-type ATP synthase alpha chain HAMAP MF_00309		PRO_0000144613
Regions
	Nucleotide binding	242 – 249	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O84310 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3780967B6914785F	FASTA	591	65,497
	10 20 30 40 50 60 MVATSKQTTQ GYVVEAYGNL LRVHVDGHVR QGEVAYVSVD DTWLKAEIIE VVGDEVKIQV 70 80 90 100 110 120 FEETQGISRG ALVTFSGHLL EAELGPGLLQ GIFDGLQNRL EILADTSLFL RRGEYVNAIC 130 140 150 160 170 180 RETVWAYTQK ASVGSVLSRG DVLGTVKEGR FDHKIMVPFS CFEEVTITWV ISSGNYTVDT 190 200 210 220 230 240 VVAKGRTSTG EELEFTMVQK WPIKQAFLEG EKVPSHEIMD VGLRVLDTQI PVLKGGTFCT 250 260 270 280 290 300 PGPFGAGKTV LQHHLSKYAA VDIVVLCACG ERAGEVVEIL QEFPHLTDPH TGQSLMHRTC 310 320 330 340 350 360 IICNTSSMPV AARESSIYLG ITIAEYYRQM GLHILLLADS TSRWAQALRE ISGRLEEIPG 370 380 390 400 410 420 EEAFPAYLAS RIAAFYERGG AVKMKDGSEG SLTICGAVSP AGGNFEEPVT QATLSVVGAF 430 440 450 460 470 480 CGLSKARADA RRYPSIDPMI SWSKYLDSVA EILEKKVPGW GESVKQASRF LEEGAEIGKR 490 500 510 520 530 540 IEVVGEEGIS MEDMEIFLKS ELYDFCYLQQ NAFDAEDCYC PFDRQIELFS LMNHIFNSRF 550 560 570 580 590 CFDCPDNARS FFLELQSKIK TLNGQKFLSE EYQKGLEVIY KLLESKMVQT V

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67901.1.
PIR	B71531.
RefSeq	NP_219813.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84310.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884810.
GenomeReviews	Gene locus CT_308 in contig AE001273_GR.
KEGG	ctr:CT308.
PATRIC	20380141. VBIChlTra43535_0329.
Phylogenomic databases
HOGENOM	HBG288114.
OMA	SRWAQAM.
ProtClustDB	PRK04192.
Family and domain databases
HAMAP	MF_00309. ATP_synth_A_arch. [Tree]
InterPro	IPR020003. ATPase_a/bsu_AS. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR022878. V-ATPase_su_A/alpha. [Graphical view]
KO	K02117.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SUPFAM	SSF50615. ATPase_a/b_N. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATA_CHLTR

Accession

Primary (citable) accession number: O84310

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program