Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O84303 (PKND_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknD

EC=2.7.11.1
Gene names
Name:pknD
Ordered Locus Names:CT_301
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth. HAMAP-Rule MF_01957

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957

Developmental stage

Expressed at early mid-phase of the developmental cycle. HAMAP-Rule MF_01957

Post-translational modification

Autophosphorylated on serine and threonine residues. HAMAP-Rule MF_01957

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957
PRO_0000171193

Regions

Domain4 – 296293Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1381Proton acceptor By similarity
Binding site331ATP By similarity

Experimental info

Sequence conflict3621A → G in AAN71626. Ref.2
Sequence conflict4151M → I in AAN71626. Ref.2
Sequence conflict6291V → L in AAN71626. Ref.2
Sequence conflict8691Y → D in AAN71626. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O84303 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: A06EC6F4B025DADB

FASTA934107,666
        10         20         30         40         50         60 
MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL REAKIAADLI 

        70         80         90        100        110        120 
HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE VLSKELEEKT SVKSFLPIFD 

       130        140        150        160        170        180 
KICATVEYIH SKGVLHRDLK PDNILLGLFG EVVIIDWGAA IFKHAKELKL EQDDEAAVSF 

       190        200        210        220        230        240 
DERNICYSSM TIPGKIVGTP DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK 

       250        260        270        280        290        300 
GRKLSYRDVV LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP 

       310        320        330        340        350        360 
EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA STRVEYTVTK 

       370        380        390        400        410        420 
SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS LIKNGIEIQK KSQEMISQQS 

       430        440        450        460        470        480 
RFAILIEKSD NRIAVFVEQA LFILHIDYLP SLGNRLGVII QDLQGMSNIA ISESIGALRV 

       490        500        510        520        530        540 
SCLAVPDAFL SEKLYDQAAI FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA 

       550        560        570        580        590        600 
LSSFDYLHGG AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR 

       610        620        630        640        650        660 
LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ VDKAPLQFRS 

       670        680        690        700        710        720 
SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA GVSGNREAFM QFSTALANVS 

       730        740        750        760        770        780 
DEITFPESLH NQKVAELMFF VKGVEALRNK DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL 

       790        800        810        820        830        840 
DEEIESFIDL LQAIYDPASE EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY 

       850        860        870        880        890        900 
SEAFILWGCY LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT 

       910        920        930 
LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
[2]"Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
Verma A., Maurelli A.T.
Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKN1.
Strain: L2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC67894.1.
AY148436 Genomic DNA. Translation: AAN71626.1.
PIRG71532.
RefSeqNP_219806.1. NC_000117.1.

3D structure databases

ProteinModelPortalO84303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT301.

PTM databases

PhosSiteP0501120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC67894; AAC67894; CT_301.
GeneID884825.
KEGGctr:CT_301.
PATRIC20380127. VBIChlTra43535_0322.

Phylogenomic databases

eggNOGCOG0515.
KOK08884.
OMAYQMLTLS.
OrthoDBEOG6W45P7.
ProtClustDBPRK13184.

Family and domain databases

HAMAPMF_01957. PknD_kinase.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKND_CHLTR
AccessionPrimary (citable) accession number: O84303
Secondary accession number(s): Q8GDH7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families