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O84303

- PKND_CHLTR

UniProt

O84303 - PKND_CHLTR

Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPUniRule annotation
    Active sitei138 – 1381Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. protein serine/threonine kinase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
    Gene namesi
    Name:pknDUniRule annotation
    Ordered Locus Names:CT_301
    OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
    Taxonomic identifieri272561 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000431: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Serine/threonine-protein kinase PknDPRO_0000171193Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues.

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosSiteiP0501120.

    Expressioni

    Developmental stagei

    Expressed at early mid-phase of the developmental cycle.

    Interactioni

    Protein-protein interaction databases

    STRINGi272561.CT301.

    Structurei

    3D structure databases

    ProteinModelPortaliO84303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 296293Protein kinaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation
    Contains 1 protein kinase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08884.
    OMAiYQMLTLS.
    OrthoDBiEOG6W45P7.

    Family and domain databases

    HAMAPiMF_01957. PknD_kinase.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR023507. Ser/Thr_kinase_PknD.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O84303-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL    50
    REAKIAADLI HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE 100
    VLSKELEEKT SVKSFLPIFD KICATVEYIH SKGVLHRDLK PDNILLGLFG 150
    EVVIIDWGAA IFKHAKELKL EQDDEAAVSF DERNICYSSM TIPGKIVGTP 200
    DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK GRKLSYRDVV 250
    LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP 300
    EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA 350
    STRVEYTVTK SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS 400
    LIKNGIEIQK KSQEMISQQS RFAILIEKSD NRIAVFVEQA LFILHIDYLP 450
    SLGNRLGVII QDLQGMSNIA ISESIGALRV SCLAVPDAFL SEKLYDQAAI 500
    FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA LSSFDYLHGG 550
    AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR 600
    LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ 650
    VDKAPLQFRS SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA 700
    GVSGNREAFM QFSTALANVS DEITFPESLH NQKVAELMFF VKGVEALRNK 750
    DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL DEEIESFIDL LQAIYDPASE 800
    EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY SEAFILWGCY 850
    LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT 900
    LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD 934
    Length:934
    Mass (Da):107,666
    Last modified:November 1, 1998 - v1
    Checksum:iA06EC6F4B025DADB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti362 – 3621A → G in AAN71626. (PubMed:14500499)Curated
    Sequence conflicti415 – 4151M → I in AAN71626. (PubMed:14500499)Curated
    Sequence conflicti629 – 6291V → L in AAN71626. (PubMed:14500499)Curated
    Sequence conflicti869 – 8691Y → D in AAN71626. (PubMed:14500499)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC67894.1.
    AY148436 Genomic DNA. Translation: AAN71626.1.
    PIRiG71532.
    RefSeqiNP_219806.1. NC_000117.1.

    Genome annotation databases

    EnsemblBacteriaiAAC67894; AAC67894; CT_301.
    GeneIDi884825.
    KEGGictr:CT_301.
    PATRICi20380127. VBIChlTra43535_0322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC67894.1 .
    AY148436 Genomic DNA. Translation: AAN71626.1 .
    PIRi G71532.
    RefSeqi NP_219806.1. NC_000117.1.

    3D structure databases

    ProteinModelPortali O84303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272561.CT301.

    PTM databases

    PhosSitei P0501120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC67894 ; AAC67894 ; CT_301 .
    GeneIDi 884825.
    KEGGi ctr:CT_301.
    PATRICi 20380127. VBIChlTra43535_0322.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08884.
    OMAi YQMLTLS.
    OrthoDBi EOG6W45P7.

    Family and domain databases

    HAMAPi MF_01957. PknD_kinase.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR023507. Ser/Thr_kinase_PknD.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
      Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
      Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D/UW-3/Cx.
    2. "Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
      Verma A., Maurelli A.T.
      Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKN1.
      Strain: L2.

    Entry informationi

    Entry nameiPKND_CHLTR
    AccessioniPrimary (citable) accession number: O84303
    Secondary accession number(s): Q8GDH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3