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O84303

- PKND_CHLTR

UniProt

O84303 - PKND_CHLTR

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Protein

Serine/threonine-protein kinase PknD

Gene
pknD, CT_301
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei138 – 1381Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknD (EC:2.7.11.1)
Gene namesi
Name:pknD
Ordered Locus Names:CT_301
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Serine/threonine-protein kinase PknDUniRule annotationPRO_0000171193Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

Phosphoprotein

PTM databases

PhosSiteiP0501120.

Expressioni

Developmental stagei

Expressed at early mid-phase of the developmental cycle.UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi272561.CT301.

Structurei

3D structure databases

ProteinModelPortaliO84303.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 296293Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK08884.
OMAiYQMLTLS.
OrthoDBiEOG6W45P7.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84303-1 [UniParc]FASTAAdd to Basket

« Hide

MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL    50
REAKIAADLI HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE 100
VLSKELEEKT SVKSFLPIFD KICATVEYIH SKGVLHRDLK PDNILLGLFG 150
EVVIIDWGAA IFKHAKELKL EQDDEAAVSF DERNICYSSM TIPGKIVGTP 200
DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK GRKLSYRDVV 250
LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP 300
EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA 350
STRVEYTVTK SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS 400
LIKNGIEIQK KSQEMISQQS RFAILIEKSD NRIAVFVEQA LFILHIDYLP 450
SLGNRLGVII QDLQGMSNIA ISESIGALRV SCLAVPDAFL SEKLYDQAAI 500
FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA LSSFDYLHGG 550
AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR 600
LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ 650
VDKAPLQFRS SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA 700
GVSGNREAFM QFSTALANVS DEITFPESLH NQKVAELMFF VKGVEALRNK 750
DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL DEEIESFIDL LQAIYDPASE 800
EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY SEAFILWGCY 850
LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT 900
LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD 934
Length:934
Mass (Da):107,666
Last modified:November 1, 1998 - v1
Checksum:iA06EC6F4B025DADB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti362 – 3621A → G in AAN71626. 1 Publication
Sequence conflicti415 – 4151M → I in AAN71626. 1 Publication
Sequence conflicti629 – 6291V → L in AAN71626. 1 Publication
Sequence conflicti869 – 8691Y → D in AAN71626. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC67894.1.
AY148436 Genomic DNA. Translation: AAN71626.1.
PIRiG71532.
RefSeqiNP_219806.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67894; AAC67894; CT_301.
GeneIDi884825.
KEGGictr:CT_301.
PATRICi20380127. VBIChlTra43535_0322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC67894.1 .
AY148436 Genomic DNA. Translation: AAN71626.1 .
PIRi G71532.
RefSeqi NP_219806.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT301.

PTM databases

PhosSitei P0501120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC67894 ; AAC67894 ; CT_301 .
GeneIDi 884825.
KEGGi ctr:CT_301.
PATRICi 20380127. VBIChlTra43535_0322.

Phylogenomic databases

eggNOGi COG0515.
KOi K08884.
OMAi YQMLTLS.
OrthoDBi EOG6W45P7.

Family and domain databases

HAMAPi MF_01957. PknD_kinase.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.
  2. "Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
    Verma A., Maurelli A.T.
    Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKN1.
    Strain: L2.

Entry informationi

Entry nameiPKND_CHLTR
AccessioniPrimary (citable) accession number: O84303
Secondary accession number(s): Q8GDH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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