O84303 (PKND_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknD
EC=2.7.11.1

Gene names

Name:	pknD
Ordered Locus Names:	CT_301

Organism

Chlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]

Taxonomic identifier

272561 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › Chlamydia trachomatis

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Together with the serine/threonine kinase pkn1, may play a role in the specific interactions with host proteins during intracellular growth. HAMAP-Rule MF_01957
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957
Developmental stage	Expressed at early mid-phase of the developmental cycle. HAMAP-Rule MF_01957
Post-translational modification	Autophosphorylated on serine and threonine residues. HAMAP-Rule MF_01957
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP protein serine/threonine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 934	934	Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957		PRO_0000171193
Regions
	Domain	4 – 296	293	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Experimental info
	Sequence conflict	362	1	A → G in AAN71626. Ref.2
	Sequence conflict	415	1	M → I in AAN71626. Ref.2
	Sequence conflict	629	1	V → L in AAN71626. Ref.2
	Sequence conflict	869	1	Y → D in AAN71626. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O84303 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: A06EC6F4B025DADB	FASTA	934	107,666
	10 20 30 40 50 60 MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL REAKIAADLI 70 80 90 100 110 120 HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE VLSKELEEKT SVKSFLPIFD 130 140 150 160 170 180 KICATVEYIH SKGVLHRDLK PDNILLGLFG EVVIIDWGAA IFKHAKELKL EQDDEAAVSF 190 200 210 220 230 240 DERNICYSSM TIPGKIVGTP DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK 250 260 270 280 290 300 GRKLSYRDVV LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP 310 320 330 340 350 360 EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA STRVEYTVTK 370 380 390 400 410 420 SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS LIKNGIEIQK KSQEMISQQS 430 440 450 460 470 480 RFAILIEKSD NRIAVFVEQA LFILHIDYLP SLGNRLGVII QDLQGMSNIA ISESIGALRV 490 500 510 520 530 540 SCLAVPDAFL SEKLYDQAAI FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA 550 560 570 580 590 600 LSSFDYLHGG AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR 610 620 630 640 650 660 LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ VDKAPLQFRS 670 680 690 700 710 720 SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA GVSGNREAFM QFSTALANVS 730 740 750 760 770 780 DEITFPESLH NQKVAELMFF VKGVEALRNK DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL 790 800 810 820 830 840 DEEIESFIDL LQAIYDPASE EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY 850 860 870 880 890 900 SEAFILWGCY LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT 910 920 930 LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
[2]	"Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1." Verma A., Maurelli A.T. Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKN1. Strain: L2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67894.1. AY148436 Genomic DNA. Translation: AAN71626.1.
PIR	G71532.
RefSeq	NP_219806.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84303.
ModBase	Search...
Protein-protein interaction databases
STRING	272561.CT301.
PTM databases
PhosSite	P0501120.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC67894; AAC67894; CT_301.
GeneID	884825.
KEGG	ctr:CT301.
PATRIC	20380127. VBIChlTra43535_0322.
Phylogenomic databases
eggNOG	COG0515.
KO	K08884.
OMA	YQMLTLS.
ProtClustDB	PRK13184.
Family and domain databases
HAMAP	MF_01957. PknD_kinase.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR023507. Ser/Thr_kinase_PknD. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKND_CHLTR

Accession

Primary (citable) accession number: O84303
Secondary accession number(s): Q8GDH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program