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Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPUniRule annotation
Active sitei138 – 1381Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:pknDUniRule annotation
Ordered Locus Names:CT_301
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Serine/threonine-protein kinase PknDPRO_0000171193Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Expressed at early mid-phase of the developmental cycle.

Interactioni

Protein-protein interaction databases

STRINGi272561.CT301.

Structurei

3D structure databases

ProteinModelPortaliO84303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 296293Protein kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiO84303.
KOiK08884.
OMAiSIFHKIC.
OrthoDBiEOG6W45P7.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL
60 70 80 90 100
REAKIAADLI HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE
110 120 130 140 150
VLSKELEEKT SVKSFLPIFD KICATVEYIH SKGVLHRDLK PDNILLGLFG
160 170 180 190 200
EVVIIDWGAA IFKHAKELKL EQDDEAAVSF DERNICYSSM TIPGKIVGTP
210 220 230 240 250
DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK GRKLSYRDVV
260 270 280 290 300
LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP
310 320 330 340 350
EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA
360 370 380 390 400
STRVEYTVTK SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS
410 420 430 440 450
LIKNGIEIQK KSQEMISQQS RFAILIEKSD NRIAVFVEQA LFILHIDYLP
460 470 480 490 500
SLGNRLGVII QDLQGMSNIA ISESIGALRV SCLAVPDAFL SEKLYDQAAI
510 520 530 540 550
FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA LSSFDYLHGG
560 570 580 590 600
AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR
610 620 630 640 650
LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ
660 670 680 690 700
VDKAPLQFRS SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA
710 720 730 740 750
GVSGNREAFM QFSTALANVS DEITFPESLH NQKVAELMFF VKGVEALRNK
760 770 780 790 800
DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL DEEIESFIDL LQAIYDPASE
810 820 830 840 850
EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY SEAFILWGCY
860 870 880 890 900
LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT
910 920 930
LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD
Length:934
Mass (Da):107,666
Last modified:November 1, 1998 - v1
Checksum:iA06EC6F4B025DADB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti362 – 3621A → G in AAN71626 (PubMed:14500499).Curated
Sequence conflicti415 – 4151M → I in AAN71626 (PubMed:14500499).Curated
Sequence conflicti629 – 6291V → L in AAN71626 (PubMed:14500499).Curated
Sequence conflicti869 – 8691Y → D in AAN71626 (PubMed:14500499).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67894.1.
AY148436 Genomic DNA. Translation: AAN71626.1.
PIRiG71532.
RefSeqiNP_219806.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67894; AAC67894; CT_301.
GeneIDi884825.
KEGGictr:CT_301.
PATRICi20380127. VBIChlTra43535_0322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67894.1.
AY148436 Genomic DNA. Translation: AAN71626.1.
PIRiG71532.
RefSeqiNP_219806.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67894; AAC67894; CT_301.
GeneIDi884825.
KEGGictr:CT_301.
PATRICi20380127. VBIChlTra43535_0322.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiO84303.
KOiK08884.
OMAiSIFHKIC.
OrthoDBiEOG6W45P7.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.
  2. "Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
    Verma A., Maurelli A.T.
    Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKN1.
    Strain: L2.

Entry informationi

Entry nameiPKND_CHLTR
AccessioniPrimary (citable) accession number: O84303
Secondary accession number(s): Q8GDH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1998
Last modified: March 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.