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Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPUniRule annotation1
Active sitei138Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-315-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:pknDUniRule annotation
Ordered Locus Names:CT_301
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001711931 – 934Serine/threonine-protein kinase PknDAdd BLAST934

Post-translational modificationi

Autophosphorylated on serine and threonine residues.

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Expressed at early mid-phase of the developmental cycle.

Structurei

3D structure databases

ProteinModelPortaliO84303
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 296Protein kinaseUniRule annotationAdd BLAST293

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9P Bacteria
COG0515 LUCA
InParanoidiO84303
KOiK12132
OMAiSIFHKIC

Family and domain databases

Gene3Di1.25.40.101 hit
HAMAPiMF_01957 PknD_kinase, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR023507 Ser/Thr_kinase_PknD
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O84303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRYELIRLI GKGGMGEVYL AHDKACSRRV ALKRIREDLS GNALLRQRFL
60 70 80 90 100
REAKIAADLI HPGIVPVYSI CSDGEAVYYT MPYIEGFSLK SLLKSVWQKE
110 120 130 140 150
VLSKELEEKT SVKSFLPIFD KICATVEYIH SKGVLHRDLK PDNILLGLFG
160 170 180 190 200
EVVIIDWGAA IFKHAKELKL EQDDEAAVSF DERNICYSSM TIPGKIVGTP
210 220 230 240 250
DYMAPESLLG VEASEKTDIY ALGLILYQML TLAFPYRRKK GRKLSYRDVV
260 270 280 290 300
LPPIEMSPYR EIPPSLSQIA MKAIAINPAD RFSSIQELRQ ALQPYLQGDP
310 320 330 340 350
EWTVKATLMA KEKSCWKYYD PILLSRYFPV LASSPAQWYN FMLSEVEISA
360 370 380 390 400
STRVEYTVTK SAVHEGMGIL FLPSKEAERG EFYCGYGLWF SVQNHELTVS
410 420 430 440 450
LIKNGIEIQK KSQEMISQQS RFAILIEKSD NRIAVFVEQA LFILHIDYLP
460 470 480 490 500
SLGNRLGVII QDLQGMSNIA ISESIGALRV SCLAVPDAFL SEKLYDQAAI
510 520 530 540 550
FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLTQA LSSFDYLHGG
560 570 580 590 600
AGAPLEYLGK ALVYQRNGSF VEEIRCLLFA LKRYSQHPEI PRLEDHLCFR
610 620 630 640 650
LYDSLHKHRS EALVFMLLIL WIAPEKISVR EEERFLRIIY HKQQATLFCQ
660 670 680 690 700
VDKAPLQFRS SKMELFLSFW TGFSLFLPEL FRRAGGLRDY QALADIFYVA
710 720 730 740 750
GVSGNREAFM QFSTALANVS DEITFPESLH NQKVAELMFF VKGVEALRNK
760 770 780 790 800
DYQKAKKLLW KTPFTLQLYA LDMFHIQAFL DEEIESFIDL LQAIYDPASE
810 820 830 840 850
EERDHILVYI IQTHLWNRDL ERAYKLLNDR FPLDEELAEY SEAFILWGCY
860 870 880 890 900
LALTGDRVVV KAHFSRCRYK YGKSALIGKC VDGDIFDYLD NLVWWEKKMT
910 920 930
LFQSYFLLRC LNESPRRYEK YRQAYLSMEN NFFD
Length:934
Mass (Da):107,666
Last modified:November 1, 1998 - v1
Checksum:iA06EC6F4B025DADB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362A → G in AAN71626 (PubMed:14500499).Curated1
Sequence conflicti415M → I in AAN71626 (PubMed:14500499).Curated1
Sequence conflicti629V → L in AAN71626 (PubMed:14500499).Curated1
Sequence conflicti869Y → D in AAN71626 (PubMed:14500499).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67894.1
AY148436 Genomic DNA Translation: AAN71626.1
PIRiG71532
RefSeqiNP_219806.1, NC_000117.1
WP_009871648.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67894; AAC67894; CT_301
GeneIDi35556511
884825
KEGGictr:CT_301
PATRICifig|272561.5.peg.322

Similar proteinsi

Entry informationi

Entry nameiPKND_CHLTR
AccessioniPrimary (citable) accession number: O84303
Secondary accession number(s): Q8GDH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome