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Protein

Probable porphobilinogen deaminase

Gene

hemC

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.By similarity

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Probable porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable porphobilinogen deaminase (EC:2.5.1.61)
Short name:
PBG
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemC
Ordered Locus Names:CT_299
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Probable porphobilinogen deaminasePRO_0000143019Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT299.

Structurei

3D structure databases

ProteinModelPortaliO84301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.Curated

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
InParanoidiO84301.
KOiK01749.
OMAiAIHSAKD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

InterProiIPR000860. HemC.
IPR022417. Porphobilin_deaminase_N.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
[Graphical view]
PRINTSiPR00151. PORPHBDMNASE.

Sequencei

Sequence statusi: Complete.

O84301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAYYNDPF LADFCLGNIP LRLASRQSSL AVLQAHECLR KLQIFFPRLW
60 70 80 90 100
GQIITTTTQG DLDQETPLCA VENTGFFTDD VDFLVQSGQC DLGIHSAKDL
110 120 130 140 150
PENPKATVVS ITASIDPRDI LVFHEKYLSI PLPRRLRIGS SSVRRKELLS
160 170 180 190 200
LLYPSAIITD IRGTIQTRLK LLEEKNFDAI VMANAAVSRL GLRLPCTKIL
210 220 230 240
PPPYHPLQGR LAITASRHIR SWRGLFLTCG ITEDVEIMCF S
Length:241
Mass (Da):26,996
Last modified:November 1, 1998 - v1
Checksum:iF89FE00C20BF7044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67892.1.
PIRiE71532.
RefSeqiNP_219804.1. NC_000117.1.
WP_009871647.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67892; AAC67892; CT_299.
GeneIDi884823.
KEGGictr:CT_299.
PATRICi20380125. VBIChlTra43535_0321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67892.1.
PIRiE71532.
RefSeqiNP_219804.1. NC_000117.1.
WP_009871647.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67892; AAC67892; CT_299.
GeneIDi884823.
KEGGictr:CT_299.
PATRICi20380125. VBIChlTra43535_0321.

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
InParanoidiO84301.
KOiK01749.
OMAiAIHSAKD.
OrthoDBiEOG6HB9Z6.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Family and domain databases

InterProiIPR000860. HemC.
IPR022417. Porphobilin_deaminase_N.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
[Graphical view]
PRINTSiPR00151. PORPHBDMNASE.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiHEM3_CHLTR
AccessioniPrimary (citable) accession number: O84301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This sequence may not function as a hydroxymethylbilane synthase because it lacks the cysteine residue necessary for attachment of the dipyrromethane cofactor.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.