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Protein

Probable porphobilinogen deaminase

Gene

hemC

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.By similarity

Caution

This sequence may not function as a hydroxymethylbilane synthase because it lacks the cysteine residue necessary for attachment of the dipyrromethane cofactor.Curated

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Probable porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-313-MONOMER
UniPathwayiUPA00251; UER00319

Names & Taxonomyi

Protein namesi
Recommended name:
Probable porphobilinogen deaminase (EC:2.5.1.61)
Short name:
PBG
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemC
Ordered Locus Names:CT_299
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430191 – 241Probable porphobilinogen deaminaseAdd BLAST241

Structurei

3D structure databases

ProteinModelPortaliO84301
SMRiO84301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.Curated

Phylogenomic databases

eggNOGiENOG4105D6W Bacteria
COG0181 LUCA
InParanoidiO84301
KOiK01749
OMAiCDLAIHS

Family and domain databases

InterProiView protein in InterPro
IPR000860 HemC
IPR022417 Porphobilin_deaminase_N
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PRINTSiPR00151 PORPHBDMNASE

Sequencei

Sequence statusi: Complete.

O84301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAYYNDPF LADFCLGNIP LRLASRQSSL AVLQAHECLR KLQIFFPRLW
60 70 80 90 100
GQIITTTTQG DLDQETPLCA VENTGFFTDD VDFLVQSGQC DLGIHSAKDL
110 120 130 140 150
PENPKATVVS ITASIDPRDI LVFHEKYLSI PLPRRLRIGS SSVRRKELLS
160 170 180 190 200
LLYPSAIITD IRGTIQTRLK LLEEKNFDAI VMANAAVSRL GLRLPCTKIL
210 220 230 240
PPPYHPLQGR LAITASRHIR SWRGLFLTCG ITEDVEIMCF S
Length:241
Mass (Da):26,996
Last modified:November 1, 1998 - v1
Checksum:iF89FE00C20BF7044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67892.1
PIRiE71532
RefSeqiNP_219804.1, NC_000117.1
WP_009871647.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67892; AAC67892; CT_299
GeneIDi35556509
884823
KEGGictr:CT_299
PATRICifig|272561.5.peg.321

Similar proteinsi

Entry informationi

Entry nameiHEM3_CHLTR
AccessioniPrimary (citable) accession number: O84301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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