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Protein

Chromosomal replication initiator protein DnaA 2

Gene

dnaA2

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 161ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-289-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA 2
Gene namesi
Name:dnaA2
Ordered Locus Names:CT_275
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141631 – 455Chromosomal replication initiator protein DnaA 2Add BLAST455

Proteomic databases

PRIDEiO84277

Structurei

3D structure databases

ProteinModelPortaliO84277
SMRiO84277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
InParanoidiO84277
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

O84277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTCNDCSTW EQFVNYIKTR CSKTAFENWI APIQVLEESS EKIRLEIPNI
60 70 80 90 100
FVQSYLLDNY KKDLCSFVPL DAEGNPALEF VVAEIKRSSP LVTPSIAKPA
110 120 130 140 150
TEVSEENKDF QLKLNGAYRF DNFIEGPSNQ FVKSAALGIA ARPGRSYNPL
160 170 180 190 200
FIHGGVGLGK THLLHAVGHY VREHHKNLRI HCITTEAFIN DLVHHLRVKS
210 220 230 240 250
IDKMKNFYRS LDLLLVDDIQ FLQNRQNFEE EFCNTFETLI HLSKQIVVTS
260 270 280 290 300
DKPPGQLKLS ERIIARMEWG LVAHVGVPDL ETRVAILQHK AEQKGLNIPN
310 320 330 340 350
EIAFYIADHV YGNVRQLEGA INKLTAYCLL FNKPLTETTV RDTLKELFRA
360 370 380 390 400
PSKQKVSVES ILKSVATVFQ VKIQDLKGSS RAKNVPLARQ VAMYLAKTLI
410 420 430 440 450
TDSLVAIGAA FGKTHSTVLY ACKTIEQKIE KDALLKNQIS LCKNNIAIDS

PQHFV
Length:455
Mass (Da):51,330
Last modified:November 1, 1998 - v1
Checksum:iF593F8FBB50A91F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67868.1
PIRiH71534
RefSeqiNP_219780.1, NC_000117.1
WP_009871622.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67868; AAC67868; CT_275
GeneIDi35556485
884847
KEGGictr:CT_275
PATRICifig|272561.5.peg.294

Similar proteinsi

Entry informationi

Entry nameiDNAA2_CHLTR
AccessioniPrimary (citable) accession number: O84277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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