O84277 (DNAA2_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA 2

Gene names

Name:	dnaA2
Ordered Locus Names:	CT_275

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Chromosomal replication initiator protein DnaA 2 HAMAP MF_00377		PRO_0000114163
Regions
	Nucleotide binding	154 – 161	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O84277 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: F593F8FBB50A91F1	FASTA	455	51,330
	10 20 30 40 50 60 MLTCNDCSTW EQFVNYIKTR CSKTAFENWI APIQVLEESS EKIRLEIPNI FVQSYLLDNY 70 80 90 100 110 120 KKDLCSFVPL DAEGNPALEF VVAEIKRSSP LVTPSIAKPA TEVSEENKDF QLKLNGAYRF 130 140 150 160 170 180 DNFIEGPSNQ FVKSAALGIA ARPGRSYNPL FIHGGVGLGK THLLHAVGHY VREHHKNLRI 190 200 210 220 230 240 HCITTEAFIN DLVHHLRVKS IDKMKNFYRS LDLLLVDDIQ FLQNRQNFEE EFCNTFETLI 250 260 270 280 290 300 HLSKQIVVTS DKPPGQLKLS ERIIARMEWG LVAHVGVPDL ETRVAILQHK AEQKGLNIPN 310 320 330 340 350 360 EIAFYIADHV YGNVRQLEGA INKLTAYCLL FNKPLTETTV RDTLKELFRA PSKQKVSVES 370 380 390 400 410 420 ILKSVATVFQ VKIQDLKGSS RAKNVPLARQ VAMYLAKTLI TDSLVAIGAA FGKTHSTVLY 430 440 450 ACKTIEQKIE KDALLKNQIS LCKNNIAIDS PQHFV

References

[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67868.1.
PIR	H71534.
RefSeq	NP_219780.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84277.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884847.
GenomeReviews	Gene locus CT_275 in contig AE001273_GR.
KEGG	ctr:CT275.
PATRIC	20380071. VBIChlTra43535_0294.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	O84277.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA2_CHLTR

Accession

Primary (citable) accession number: O84277

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program