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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidC
Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Gene namesi
Name:yidC
Ordered Locus Names:CT_251
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence analysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence analysisAdd
BLAST
Transmembranei688 – 70821HelicalSequence analysisAdd
BLAST
Transmembranei735 – 75521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 787767Membrane protein insertase YidCPRO_0000124707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi21 – 211N-palmitoyl cysteineSequence analysis
Lipidationi21 – 211S-diacylglycerol cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).By similarity

Protein-protein interaction databases

STRINGi272561.CT251.

Structurei

3D structure databases

ProteinModelPortaliO84253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
InParanoidiO84253.
KOiK03217.
OMAiGLNIYWL.
OrthoDBiEOG6X6RF2.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O84253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMNKRTLLF VSLVSAAFLG CQIFFGYRDL KSCQDLAEKQ RAISEQILAS
60 70 80 90 100
TEQLSVVPWT ASLEESESVN QYAIRLGNRL LLLTKGGSHP EVYSRGTYWS
110 120 130 140 150
LIEQTSTFGG ILVSLYGETG QEVLSKGSSV YLPNQRDAFP VLVAEFRSNQ
160 170 180 190 200
EPLVFLGEYK DGKIANKAGA IYGTSLVFLN TGNGFVPLGI YNSKEECVES
210 220 230 240 250
LDLPMARAVV FADKENPTAS GSYYMLSNEY MQIVVSQESG AIEGINLPFA
260 270 280 290 300
SDQEENKSIV NEIGFDRELA INSPSEASFP GVETIDSQRQ NIANVVGGYY
310 320 330 340 350
PLLRRGTLSD VKKRVPAQYQ ALNIVSGREL ASPVATGFRV VSFDNKTLIL
360 370 380 390 400
ESGDGGIRRT YSLGEQPYAF ELEIQTTQGR EDLWITSGVP EVEIMSNAFV
410 420 430 440 450
PAVKYHAVKK NKSDLFNVKL PKAKDSLLVR NNATPQWILN SNGYFGVILT
460 470 480 490 500
PRIPIPAGYA SSFIPGNVVP TRLSQLPPKD QAYPASKYPG YTAMLPLPKE
510 520 530 540 550
AGRYQFMVYA GPLADPTLKA LDRANANSKG ETPEYVDAIA FRGFFSFITE
560 570 580 590 600
PFAALLFVIM KFFKFLTGSW GISIILLTIV LKLLLYPLNA WSIRSMRRMQ
610 620 630 640 650
KLSPYIQEIQ QKYKREPKRA QMEIMALYKM NKVNPITGCL PLLIQIPFLI
660 670 680 690 700
AMFDLLKSSF LLRGASFIPG WIDNLTAPDV LFSWETPIWF IGKEFHLLPI
710 720 730 740 750
LLGVVMFAQQ KISAVKRSGP ASDQQRQQEA MGTMMALLFT FMFYNFPSGL
760 770 780
NIYWFSSMLL GVIQQWVTNK ILDEKHLQHE VIINKKR
Length:787
Mass (Da):88,024
Last modified:November 1, 1998 - v1
Checksum:i64592E3BC8EEB54B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67844.1.
PIRiE71537.
RefSeqiNP_219756.1. NC_000117.1.
WP_010725139.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67844; AAC67844; CT_251.
GeneIDi884867.
KEGGictr:CT_251.
PATRICi20380019. VBIChlTra43535_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67844.1.
PIRiE71537.
RefSeqiNP_219756.1. NC_000117.1.
WP_010725139.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67844; AAC67844; CT_251.
GeneIDi884867.
KEGGictr:CT_251.
PATRICi20380019. VBIChlTra43535_0268.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
InParanoidiO84253.
KOiK03217.
OMAiGLNIYWL.
OrthoDBiEOG6X6RF2.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiYIDC_CHLTR
AccessioniPrimary (citable) accession number: O84253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.